Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/59629 |
Resumo: | Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil. |
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Souza, Mariana C.Pádua, Tatiana A.Henriques, Maria G.2023-07-18T03:30:07Z2023-07-18T03:30:07Z2015SOUZA, Mariana C.; PÁDUA, Tatiana A.; HENRIQUES, Maria G. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation, v. 2015, p. 1-11, 2015.0962-9351https://www.arca.fiocruz.br/handle/icict/5962910.1155/2015/1689371466-1861engHindawi PublishingAnimalsBlood-Brain BarrierBrainEndotheliumHumansLeukocytesMalariaSevere MalariaEndothelial-LeukocyteBrainPlasmodium-falciparumEndothelial-Leukocyte Interaction in Severe Malaria: Beyond the Braininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleOswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil.Malaria is the most important parasitic disease worldwide, accounting for 1 million deaths each year. Severe malaria is a systemic illness characterized by dysfunction of brain tissue and of one or more peripheral organs as lungs and kidney. The most severe and most studied form of malaria is associated with cerebral complications due to capillary congestion and the adhesion of infected erythrocytes, platelets, and leukocytes to brain vasculature. Thus, leukocyte rolling and adhesion in the brain vascular bed during severe malaria is singular and distinct from other models of inflammation. The leukocyte/endothelium interaction and neutrophil accumulation are also observed in the lungs. However, lung interactions differ from brain interactions, likely due to differences in the blood-brain barrier and blood-air barrier tight junction composition of the brain and lung endothelium. Here, we review the importance of endothelial dysfunction and the mechanism of leukocyte/endothelium interaction during severe malaria. Furthermore, we hypothesize a possible use of adjunctive therapies to antimalarial drugs that target the interaction between the leukocytes and the endothelium.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/59629/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINAL10.1155_2015_168937.pdfapplication/pdf5718155https://www.arca.fiocruz.br/bitstream/icict/59629/2/10.1155_2015_168937.pdfb9b1b6243a0c64bf1d139cbf3695ab71MD52icict/596292023-07-18 22:04:46.276oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-19T01:04:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.en_US.fl_str_mv |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
title |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
spellingShingle |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain Souza, Mariana C. Animals Blood-Brain Barrier Brain Endothelium Humans Leukocytes Malaria Severe Malaria Endothelial-Leukocyte Brain Plasmodium-falciparum |
title_short |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
title_full |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
title_fullStr |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
title_full_unstemmed |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
title_sort |
Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain |
author |
Souza, Mariana C. |
author_facet |
Souza, Mariana C. Pádua, Tatiana A. Henriques, Maria G. |
author_role |
author |
author2 |
Pádua, Tatiana A. Henriques, Maria G. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Souza, Mariana C. Pádua, Tatiana A. Henriques, Maria G. |
dc.subject.mesh.en_US.fl_str_mv |
Animals Blood-Brain Barrier Brain Endothelium Humans Leukocytes Malaria |
topic |
Animals Blood-Brain Barrier Brain Endothelium Humans Leukocytes Malaria Severe Malaria Endothelial-Leukocyte Brain Plasmodium-falciparum |
dc.subject.en.en_US.fl_str_mv |
Severe Malaria Endothelial-Leukocyte Brain Plasmodium-falciparum |
description |
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil / Oswaldo Cruz Foundation. Center for Technological Development in Health. National Institute for Science and Technology on Innovation on Neglected Diseases. Rio de Janeiro, RJ, Brazil. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2023-07-18T03:30:07Z |
dc.date.available.fl_str_mv |
2023-07-18T03:30:07Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SOUZA, Mariana C.; PÁDUA, Tatiana A.; HENRIQUES, Maria G. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation, v. 2015, p. 1-11, 2015. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/59629 |
dc.identifier.issn.en_US.fl_str_mv |
0962-9351 |
dc.identifier.doi.none.fl_str_mv |
10.1155/2015/168937 |
dc.identifier.eissn.none.fl_str_mv |
1466-1861 |
identifier_str_mv |
SOUZA, Mariana C.; PÁDUA, Tatiana A.; HENRIQUES, Maria G. Endothelial-Leukocyte Interaction in Severe Malaria: Beyond the Brain. Mediators of Inflammation, v. 2015, p. 1-11, 2015. 0962-9351 10.1155/2015/168937 1466-1861 |
url |
https://www.arca.fiocruz.br/handle/icict/59629 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Hindawi Publishing |
publisher.none.fl_str_mv |
Hindawi Publishing |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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Repositório Institucional da FIOCRUZ (ARCA) |
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