Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model

Detalhes bibliográficos
Autor(a) principal: Rosário, H. Sobral do
Data de Publicação: 2000
Outros Autores: Sargento, L., Saldanha, C., Martins e Silva, J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/17774
Resumo: Copyright © 2000 by Academic Press
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spelling Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal modelSodium fluoresceinLeukocyte-endothelial interactionIn vivo microscopyCopyright © 2000 by Academic PressSodium fluorescein (NaF) has been widely used as a contrast dye in clinical practice for the investigation of the chorioretinal microcirculation. Several of its derivatives are also used in fluorescence techniques for microcirculatory research. NaF circulates in blood largely associated with plasma proteins (namely albumin), and, to a shorter extent, with the erythrocyte membrane (Delori et al., 1978). Its presence in circulation has been linked to the occurrence of detrimental effects in blood homeostasis. Jung et al. (1995) reported that NaF angiography decreases microvascular blood flow, as measured by prolongation of retinal circulation time. NaF injection for retinal angiography induces an increase of circulating histamine (Arroyave et al., 1979), suggesting a proinflammatory effect of NaF. Also, an association between in vitro labeling of leukocytes with fluorescein derivatives and modification of their functional properties has been demonstrated (DeClerck et al., 1994), and in other experimental settings fluorescein isothiocyanate is used in vitro as a hapten to elicit nonspecific stimulation of lymphocyte subsets (Hughes et al., 1995). The objective of this preliminary work was to determine the microvascular proinflammatory effects of NaF in an animal experimental model, as measured by leukocyte-endothelial interaction using intravital microscopy.ElsevierRepositório da Universidade de LisboaRosário, H. Sobral doSargento, L.Saldanha, C.Martins e Silva, J.2015-03-23T11:09:56Z20002000-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17774engMicrovascular Research 59, 386–389 (2000)0026-2862http://dx.doi.org/10.1006/mvre.1999.2232metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:36Zoai:repositorio.ul.pt:10451/17774Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:32.310325Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
title Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
spellingShingle Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
Rosário, H. Sobral do
Sodium fluorescein
Leukocyte-endothelial interaction
In vivo microscopy
title_short Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
title_full Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
title_fullStr Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
title_full_unstemmed Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
title_sort Sodium fluorescein-induced changes in leukocyte-endothelial interaction in an animal model
author Rosário, H. Sobral do
author_facet Rosário, H. Sobral do
Sargento, L.
Saldanha, C.
Martins e Silva, J.
author_role author
author2 Sargento, L.
Saldanha, C.
Martins e Silva, J.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Rosário, H. Sobral do
Sargento, L.
Saldanha, C.
Martins e Silva, J.
dc.subject.por.fl_str_mv Sodium fluorescein
Leukocyte-endothelial interaction
In vivo microscopy
topic Sodium fluorescein
Leukocyte-endothelial interaction
In vivo microscopy
description Copyright © 2000 by Academic Press
publishDate 2000
dc.date.none.fl_str_mv 2000
2000-01-01T00:00:00Z
2015-03-23T11:09:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/17774
url http://hdl.handle.net/10451/17774
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microvascular Research 59, 386–389 (2000)
0026-2862
http://dx.doi.org/10.1006/mvre.1999.2232
dc.rights.driver.fl_str_mv metadata only access
info:eu-repo/semantics/openAccess
rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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