Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer

Detalhes bibliográficos
Autor(a) principal: Nosrati, Hamed
Data de Publicação: 2022
Outros Autores: Seidi, Farzad, Hosseinmirzaei, Ali, Mousazadeh, Navid, Mohammadi, Ali, Ghaffarlou, Mohammadreza, Danafar, Hossein, Conde, João, Sharafi, Ali
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/154200
Resumo: This work was supported by the Deputy of Research of Zanjan University of Medical Sciences (A-12-848-30). J.C. acknowledges financial support from the European Research Council – ERC Starting Grant 848325.
id RCAP_19ff138748adde665538ddfb648917b0
oai_identifier_str oai:run.unl.pt:10362/154200
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancerSDG 3 - Good Health and Well-beingThis work was supported by the Deputy of Research of Zanjan University of Medical Sciences (A-12-848-30). J.C. acknowledges financial support from the European Research Council – ERC Starting Grant 848325.An optimal radiosensitizer with improved tumor retention have an important effect in tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) were developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy was improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments showed that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer. This article is protected by copyright. All rights reserved.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Centre for Toxicogenomics and Human Health (ToxOmics)RUNNosrati, HamedSeidi, FarzadHosseinmirzaei, AliMousazadeh, NavidMohammadi, AliGhaffarlou, MohammadrezaDanafar, HosseinConde, JoãoSharafi, Ali2023-06-20T22:19:09Z2022-02-022022-02-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/154200eng2192-2640PURE: 35091058https://doi.org/10.1002/adhm.202102321info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:36:38Zoai:run.unl.pt:10362/154200Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:31.680609Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
title Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
spellingShingle Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
Nosrati, Hamed
SDG 3 - Good Health and Well-being
title_short Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
title_full Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
title_fullStr Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
title_full_unstemmed Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
title_sort Prodrug polymeric nanoconjugates encapsulating gold nanoparticles for enhanced X-Ray radiation therapy in breast cancer
author Nosrati, Hamed
author_facet Nosrati, Hamed
Seidi, Farzad
Hosseinmirzaei, Ali
Mousazadeh, Navid
Mohammadi, Ali
Ghaffarlou, Mohammadreza
Danafar, Hossein
Conde, João
Sharafi, Ali
author_role author
author2 Seidi, Farzad
Hosseinmirzaei, Ali
Mousazadeh, Navid
Mohammadi, Ali
Ghaffarlou, Mohammadreza
Danafar, Hossein
Conde, João
Sharafi, Ali
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Centre for Toxicogenomics and Human Health (ToxOmics)
RUN
dc.contributor.author.fl_str_mv Nosrati, Hamed
Seidi, Farzad
Hosseinmirzaei, Ali
Mousazadeh, Navid
Mohammadi, Ali
Ghaffarlou, Mohammadreza
Danafar, Hossein
Conde, João
Sharafi, Ali
dc.subject.por.fl_str_mv SDG 3 - Good Health and Well-being
topic SDG 3 - Good Health and Well-being
description This work was supported by the Deputy of Research of Zanjan University of Medical Sciences (A-12-848-30). J.C. acknowledges financial support from the European Research Council – ERC Starting Grant 848325.
publishDate 2022
dc.date.none.fl_str_mv 2022-02-02
2022-02-02T00:00:00Z
2023-06-20T22:19:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/154200
url http://hdl.handle.net/10362/154200
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2192-2640
PURE: 35091058
https://doi.org/10.1002/adhm.202102321
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799138142218878976

Registros relacionados