Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study

Detalhes bibliográficos
Autor(a) principal: Ferreira, Isabel C. F. R.
Data de Publicação: 2004
Outros Autores: Calhelha, Ricardo C., Estevinho, Letícia M., Queiroz, Maria João R. P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/2239
Resumo: Gram positive (Bacillus cereus, Bacillus subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethyl benzo[b]thiophene series bearing different substituents, synthesised by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.
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spelling Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation studyDiarylaminesAntimicrobial activitySARBenzothiophenesScience & TechnologyGram positive (Bacillus cereus, Bacillus subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethyl benzo[b]thiophene series bearing different substituents, synthesised by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.Fundação Calouste Gulbenkian. Fundação para a Ciência e Tecnologia.ElsevierUniversidade do MinhoFerreira, Isabel C. F. R.Calhelha, Ricardo C.Estevinho, Letícia M.Queiroz, Maria João R. P.20042004-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/2239eng“Bioorganic and medical chemistry letters”. 14 (2004) 5831-5833.0960-894X10.1016/j.bmcl.2004.09.03815501050info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:39:29ZPortal AgregadorONG
dc.title.none.fl_str_mv Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
title Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
spellingShingle Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
Ferreira, Isabel C. F. R.
Diarylamines
Antimicrobial activity
SAR
Benzothiophenes
Science & Technology
title_short Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
title_full Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
title_fullStr Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
title_full_unstemmed Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
title_sort Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series : a structure-activity evaluation study
author Ferreira, Isabel C. F. R.
author_facet Ferreira, Isabel C. F. R.
Calhelha, Ricardo C.
Estevinho, Letícia M.
Queiroz, Maria João R. P.
author_role author
author2 Calhelha, Ricardo C.
Estevinho, Letícia M.
Queiroz, Maria João R. P.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ferreira, Isabel C. F. R.
Calhelha, Ricardo C.
Estevinho, Letícia M.
Queiroz, Maria João R. P.
dc.subject.por.fl_str_mv Diarylamines
Antimicrobial activity
SAR
Benzothiophenes
Science & Technology
topic Diarylamines
Antimicrobial activity
SAR
Benzothiophenes
Science & Technology
description Gram positive (Bacillus cereus, Bacillus subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethyl benzo[b]thiophene series bearing different substituents, synthesised by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated.
publishDate 2004
dc.date.none.fl_str_mv 2004
2004-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/2239
url http://hdl.handle.net/1822/2239
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv “Bioorganic and medical chemistry letters”. 14 (2004) 5831-5833.
0960-894X
10.1016/j.bmcl.2004.09.038
15501050
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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