HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10400.18/8293 |
Resumo: | This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention? |
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HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent ChromiumHexavalent ChromiumChromiumBiomonitoringEffect BiomarkersMicronuclei8-OHdGMDAOccupational ExposureComet AssayOxidative StressEnvironmental GenotoxicityEuropean Human Biomonitoring InitiativeHBM4EUEuropeCrómioExposição OcupacionalMicronúcleosBiomonitorizaçaoDeterminantes da Saúde e da DoençaEstados de Saúde e de DoençaBiomarcadores de EfeitoGenotoxicidade AmbientalEuropaThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2'-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries.MDPIRepositório Científico do Instituto Nacional de SaúdeTavares, AnaAimonen, KukkaNdaw, SophieFučić, AleksandraCatalán, JuliaDuca, Radu CorneliuGodderis, LodeGomes, Bruno C.Janasik, BeataLadeira, CarinaLouro, HenriquetaNamorado, SóniaNieuwenhuyse, An VanNorppa, HannuScheepers, PaulVentura, CéliaVerdonck, JelleViegas, SusanaWasowicz, WojciechSantonen, TiinaSilva, M.J.on behalf of the HBM4EU Chromates Study Team2022-11-02T13:55:04Z2022-08-182022-08-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8293engToxics. 2022 Aug 18;10(8):483. doi: 10.3390/toxics100804832305-630410.3390/toxics10080483info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:31ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| spellingShingle |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium Tavares, Ana Hexavalent Chromium Chromium Biomonitoring Effect Biomarkers Micronuclei 8-OHdG MDA Occupational Exposure Comet Assay Oxidative Stress Environmental Genotoxicity European Human Biomonitoring Initiative HBM4EU Europe Crómio Exposição Ocupacional Micronúcleos Biomonitorizaçao Determinantes da Saúde e da Doença Estados de Saúde e de Doença Biomarcadores de Efeito Genotoxicidade Ambiental Europa |
| title_short |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_full |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_fullStr |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_full_unstemmed |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_sort |
HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| author |
Tavares, Ana |
| author_facet |
Tavares, Ana Aimonen, Kukka Ndaw, Sophie Fučić, Aleksandra Catalán, Julia Duca, Radu Corneliu Godderis, Lode Gomes, Bruno C. Janasik, Beata Ladeira, Carina Louro, Henriqueta Namorado, Sónia Nieuwenhuyse, An Van Norppa, Hannu Scheepers, Paul Ventura, Célia Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Santonen, Tiina Silva, M.J. on behalf of the HBM4EU Chromates Study Team |
| author_role |
author |
| author2 |
Aimonen, Kukka Ndaw, Sophie Fučić, Aleksandra Catalán, Julia Duca, Radu Corneliu Godderis, Lode Gomes, Bruno C. Janasik, Beata Ladeira, Carina Louro, Henriqueta Namorado, Sónia Nieuwenhuyse, An Van Norppa, Hannu Scheepers, Paul Ventura, Célia Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Santonen, Tiina Silva, M.J. on behalf of the HBM4EU Chromates Study Team |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
| dc.contributor.author.fl_str_mv |
Tavares, Ana Aimonen, Kukka Ndaw, Sophie Fučić, Aleksandra Catalán, Julia Duca, Radu Corneliu Godderis, Lode Gomes, Bruno C. Janasik, Beata Ladeira, Carina Louro, Henriqueta Namorado, Sónia Nieuwenhuyse, An Van Norppa, Hannu Scheepers, Paul Ventura, Célia Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Santonen, Tiina Silva, M.J. on behalf of the HBM4EU Chromates Study Team |
| dc.subject.por.fl_str_mv |
Hexavalent Chromium Chromium Biomonitoring Effect Biomarkers Micronuclei 8-OHdG MDA Occupational Exposure Comet Assay Oxidative Stress Environmental Genotoxicity European Human Biomonitoring Initiative HBM4EU Europe Crómio Exposição Ocupacional Micronúcleos Biomonitorizaçao Determinantes da Saúde e da Doença Estados de Saúde e de Doença Biomarcadores de Efeito Genotoxicidade Ambiental Europa |
| topic |
Hexavalent Chromium Chromium Biomonitoring Effect Biomarkers Micronuclei 8-OHdG MDA Occupational Exposure Comet Assay Oxidative Stress Environmental Genotoxicity European Human Biomonitoring Initiative HBM4EU Europe Crómio Exposição Ocupacional Micronúcleos Biomonitorizaçao Determinantes da Saúde e da Doença Estados de Saúde e de Doença Biomarcadores de Efeito Genotoxicidade Ambiental Europa |
| description |
This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention? |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-11-02T13:55:04Z 2022-08-18 2022-08-18T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/8293 |
| url |
http://hdl.handle.net/10400.18/8293 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Toxics. 2022 Aug 18;10(8):483. doi: 10.3390/toxics10080483 2305-6304 10.3390/toxics10080483 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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