HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium

Detalhes bibliográficos
Autor(a) principal: Tavares, Ana
Data de Publicação: 2022
Outros Autores: Aimonen, Kukka, Ndaw, Sophie, Fučić, Aleksandra, Catalán, Julia, Duca, Radu Corneliu, Godderis, Lode, Gomes, Bruno C., Janasik, Beata, Ladeira, Carina, Louro, Henriqueta, Namorado, Sónia, Nieuwenhuyse, An Van, Norppa, Hannu, Scheepers, Paul T. J., Ventura, Célia, Verdonck, Jelle, Viegas, Susana, Wasowicz, Wojciech, Santonen, Tiina, Silva, Maria João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14925
Resumo: European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 733032).
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spelling HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromiumEffect biomarkersMicronucleiComet assayMDA8-OHdGChromateOccupational exposureBiomonitoringHBM4EUEuropean Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 733032).A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2′-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within a company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.MDPIRCIPLTavares, AnaAimonen, KukkaNdaw, SophieFučić, AleksandraCatalán, JuliaDuca, Radu CorneliuGodderis, LodeGomes, Bruno C.Janasik, BeataLadeira, CarinaLouro, HenriquetaNamorado, SóniaNieuwenhuyse, An VanNorppa, HannuScheepers, Paul T. J.Ventura, CéliaVerdonck, JelleViegas, SusanaWasowicz, WojciechSantonen, TiinaSilva, Maria João2022-08-23T09:50:17Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14925engTavares A, Aimonen K, Ndaw S, Fučić A, Catalán J, Ladeira C, et al. HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium. Toxics. 2022;10(8):483.10.3390/toxics10080483info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:11:43ZPortal AgregadorONG
dc.title.none.fl_str_mv HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
title HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
spellingShingle HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
Tavares, Ana
Effect biomarkers
Micronuclei
Comet assay
MDA
8-OHdG
Chromate
Occupational exposure
Biomonitoring
HBM4EU
title_short HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
title_full HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
title_fullStr HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
title_full_unstemmed HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
title_sort HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium
author Tavares, Ana
author_facet Tavares, Ana
Aimonen, Kukka
Ndaw, Sophie
Fučić, Aleksandra
Catalán, Julia
Duca, Radu Corneliu
Godderis, Lode
Gomes, Bruno C.
Janasik, Beata
Ladeira, Carina
Louro, Henriqueta
Namorado, Sónia
Nieuwenhuyse, An Van
Norppa, Hannu
Scheepers, Paul T. J.
Ventura, Célia
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Santonen, Tiina
Silva, Maria João
author_role author
author2 Aimonen, Kukka
Ndaw, Sophie
Fučić, Aleksandra
Catalán, Julia
Duca, Radu Corneliu
Godderis, Lode
Gomes, Bruno C.
Janasik, Beata
Ladeira, Carina
Louro, Henriqueta
Namorado, Sónia
Nieuwenhuyse, An Van
Norppa, Hannu
Scheepers, Paul T. J.
Ventura, Célia
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Santonen, Tiina
Silva, Maria João
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Tavares, Ana
Aimonen, Kukka
Ndaw, Sophie
Fučić, Aleksandra
Catalán, Julia
Duca, Radu Corneliu
Godderis, Lode
Gomes, Bruno C.
Janasik, Beata
Ladeira, Carina
Louro, Henriqueta
Namorado, Sónia
Nieuwenhuyse, An Van
Norppa, Hannu
Scheepers, Paul T. J.
Ventura, Célia
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Santonen, Tiina
Silva, Maria João
dc.subject.por.fl_str_mv Effect biomarkers
Micronuclei
Comet assay
MDA
8-OHdG
Chromate
Occupational exposure
Biomonitoring
HBM4EU
topic Effect biomarkers
Micronuclei
Comet assay
MDA
8-OHdG
Chromate
Occupational exposure
Biomonitoring
HBM4EU
description European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 733032).
publishDate 2022
dc.date.none.fl_str_mv 2022-08-23T09:50:17Z
2022-08
2022-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14925
url http://hdl.handle.net/10400.21/14925
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Tavares A, Aimonen K, Ndaw S, Fučić A, Catalán J, Ladeira C, et al. HBM4EU chromates study: genotoxicity and oxidative stress biomarkers in workers exposed to hexavalent chromium. Toxics. 2022;10(8):483.
10.3390/toxics10080483
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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