HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
| Autor(a) principal: | |
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| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/143633 |
Resumo: | Funding: This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium8-OHdGbiomonitoringchromatecomet assayeffect biomarkersMDAmicronucleioccupational exposureSDG 3 - Good Health and Well-beingFunding: This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries.A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2'-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity ( p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels ( p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.Centre for Toxicogenomics and Human Health (ToxOmics)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - Pólo ENSPEscola Nacional de Saúde Pública (ENSP)Centro de Investigação em Saúde Pública (CISP/PHRC)RUNTavares, AnaAimonen, KukkaNdaw, SophieFučić, AleksandraCatalán, JuliaDuca, Radu CorneliuGodderis, LodeGomes, Bruno CJanasik, BeataLadeira, CarinaLouro, HenriquetaNamorado, SóniaNieuwenhuyse, An VanNorppa, HannuScheepers, Paul T JVentura, CéliaVerdonck, JelleViegas, SusanaWasowicz, WojciechSantonen, TiinaSilva, Maria João2022-09-09T22:42:06Z2022-08-182022-08-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/143633eng2305-6304PURE: 46260069https://doi.org/10.3390/toxics10080483info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-10T16:09:10ZPortal AgregadorONG |
| dc.title.none.fl_str_mv |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| spellingShingle |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium Tavares, Ana 8-OHdG biomonitoring chromate comet assay effect biomarkers MDA micronuclei occupational exposure SDG 3 - Good Health and Well-being |
| title_short |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_full |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_fullStr |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_full_unstemmed |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| title_sort |
HBM4EU Chromates Study-Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium |
| author |
Tavares, Ana |
| author_facet |
Tavares, Ana Aimonen, Kukka Ndaw, Sophie Fučić, Aleksandra Catalán, Julia Duca, Radu Corneliu Godderis, Lode Gomes, Bruno C Janasik, Beata Ladeira, Carina Louro, Henriqueta Namorado, Sónia Nieuwenhuyse, An Van Norppa, Hannu Scheepers, Paul T J Ventura, Célia Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Santonen, Tiina Silva, Maria João |
| author_role |
author |
| author2 |
Aimonen, Kukka Ndaw, Sophie Fučić, Aleksandra Catalán, Julia Duca, Radu Corneliu Godderis, Lode Gomes, Bruno C Janasik, Beata Ladeira, Carina Louro, Henriqueta Namorado, Sónia Nieuwenhuyse, An Van Norppa, Hannu Scheepers, Paul T J Ventura, Célia Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Santonen, Tiina Silva, Maria João |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Centre for Toxicogenomics and Human Health (ToxOmics) NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - Pólo ENSP Escola Nacional de Saúde Pública (ENSP) Centro de Investigação em Saúde Pública (CISP/PHRC) RUN |
| dc.contributor.author.fl_str_mv |
Tavares, Ana Aimonen, Kukka Ndaw, Sophie Fučić, Aleksandra Catalán, Julia Duca, Radu Corneliu Godderis, Lode Gomes, Bruno C Janasik, Beata Ladeira, Carina Louro, Henriqueta Namorado, Sónia Nieuwenhuyse, An Van Norppa, Hannu Scheepers, Paul T J Ventura, Célia Verdonck, Jelle Viegas, Susana Wasowicz, Wojciech Santonen, Tiina Silva, Maria João |
| dc.subject.por.fl_str_mv |
8-OHdG biomonitoring chromate comet assay effect biomarkers MDA micronuclei occupational exposure SDG 3 - Good Health and Well-being |
| topic |
8-OHdG biomonitoring chromate comet assay effect biomarkers MDA micronuclei occupational exposure SDG 3 - Good Health and Well-being |
| description |
Funding: This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-09-09T22:42:06Z 2022-08-18 2022-08-18T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/143633 |
| url |
http://hdl.handle.net/10362/143633 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2305-6304 PURE: 46260069 https://doi.org/10.3390/toxics10080483 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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1777303077906284544 |