Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/43776 |
Resumo: | Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions. |
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Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystalsBiological potentialCNC-CTABCurcuminDelivery systemIntestinal permeabilityCurcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions.Veritati - Repositório Institucional da Universidade Católica PortuguesaCasanova, FranciscaPereira, Carla F.Ribeiro, Alessandra B.Castro, Pedro M.Freixo, RicardoMartins, EvaTavares-Valente, DianaFernandes, João C.Pintado, Manuela E.Ramos, Óscar L.2024-01-30T18:58:09Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/43776eng1424-824710.3390/ph1612173785180730882PMC1074750738139863001131314000001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-06T01:37:39Zoai:repositorio.ucp.pt:10400.14/43776Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T02:13:48.892492Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
title |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
spellingShingle |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals Casanova, Francisca Biological potential CNC-CTAB Curcumin Delivery system Intestinal permeability |
title_short |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
title_full |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
title_fullStr |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
title_full_unstemmed |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
title_sort |
Biological potential and bioaccessibility of encapsulated curcumin into cetyltrimethylammonium bromide modified cellulose nanocrystals |
author |
Casanova, Francisca |
author_facet |
Casanova, Francisca Pereira, Carla F. Ribeiro, Alessandra B. Castro, Pedro M. Freixo, Ricardo Martins, Eva Tavares-Valente, Diana Fernandes, João C. Pintado, Manuela E. Ramos, Óscar L. |
author_role |
author |
author2 |
Pereira, Carla F. Ribeiro, Alessandra B. Castro, Pedro M. Freixo, Ricardo Martins, Eva Tavares-Valente, Diana Fernandes, João C. Pintado, Manuela E. Ramos, Óscar L. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Casanova, Francisca Pereira, Carla F. Ribeiro, Alessandra B. Castro, Pedro M. Freixo, Ricardo Martins, Eva Tavares-Valente, Diana Fernandes, João C. Pintado, Manuela E. Ramos, Óscar L. |
dc.subject.por.fl_str_mv |
Biological potential CNC-CTAB Curcumin Delivery system Intestinal permeability |
topic |
Biological potential CNC-CTAB Curcumin Delivery system Intestinal permeability |
description |
Curcumin is a natural phenolic compound with important biological functions. Despite its demonstrated efficacy in vitro, curcumin biological activities in vivo are dependent on its bioaccessibility and bioavailability, which have been highlighted as a crucial challenge. Cetyltrimethylammonium bromide-modified cellulose nanocrystals (CNC-CTAB) have been shown to be effective in curcumin encapsulation, as they have the potential to enhance biological outcomes. This study evaluated the biological effects of curcumin encapsulated within CNC-CTAB structures, namely its antioxidant, anti-inflammatory and antimicrobial properties, as well as the release profile under digestion conditions and intestinal permeability. Encapsulated curcumin demonstrated antioxidant and anti-inflammatory properties, effectively reducing reactive oxygen species and cytokine production by intestinal cells. The delivery system exhibited antimicrobial properties against Campylobacter jejuni bacteria, further suggesting its potential in mitigating intestinal inflammation. The system showed the ability to protect curcumin from degradation and facilitate its interaction with the intestinal epithelium, highlighting the potential of CNC-CTAB as carrier to enhance curcumin intestinal biological functions. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12 2023-12-01T00:00:00Z 2024-01-30T18:58:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/43776 |
url |
http://hdl.handle.net/10400.14/43776 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1424-8247 10.3390/ph16121737 85180730882 PMC10747507 38139863 001131314000001 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137240849317888 |