Efficacy of fluralaner against canine generalized demodicosis

Detalhes bibliográficos
Autor(a) principal: Lopes, Natália Lôres
Data de Publicação: 2019
Outros Autores: Carvalho, Flavia Clare Goulart, Berman, Renata, Machado, Marília Alves, Trivisol-Medeiros, Carolina de Moraes Barbalho, Fernandes, Julio Israel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Veterinary Medicine
Texto Completo: https://rbmv.org/BJVM/article/view/1017
Resumo: Demodicosis is a parasitic dermatopathy, resulting from the excessive proliferation of Demodex mites. The rateat which this disease is encountered in the pet clinic is high, despite recent advances in the treatment ofthe disease. The aim of this study, which was conducted in Brazil, was to analyze the efficacy of fluralanerin the treatment of demodicosis in dogs. Fifteen dogs with generalized demodicosis that were diagnosedwith Demodex sp. mites from skin scraping were included. All animals were treated with fluralaner at adose of 25 mg/kg, following the manufacturer’s recommendations for the treatment of ectoparasites.The effectiveness of the treatment was evaluated based on clinical improvement of the animals andthe time required to obtain two consecutive negative skin scrapes 30 days apart (parasitological cure).The main clinical signs observed were alopecia (100%; 15/15); erythema (86.7%; 10/15); and hypotrichosis,papule, crusts, hyperpigmentation, and hyperkeratosis (26.7%; 4/15). Of the 15 animals evaluated, two ofthem were excluded for not returning for the second evaluation in 60 days, although they had the firstnegative skin scrape. After 30 days, six (46.2%) from 13 animals that concluded the study presented thefirst negative skin scraping. At the end of the study, all dogs presented parasitological cure and clinicalimprovement, except for three animals. One for developing atopic dermatitis and two that lived in ananimal shelter. In conclusion, a single oral dose of fluralaner is effective in the treatment of generalizeddemodicosis in dogs.
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spelling Efficacy of fluralaner against canine generalized demodicosisEficácia do fluralaner contra demodiciose canina generalizadacãesacaricidaisoxazolinadogsacaricidalisoxazolinesDemodicosis is a parasitic dermatopathy, resulting from the excessive proliferation of Demodex mites. The rateat which this disease is encountered in the pet clinic is high, despite recent advances in the treatment ofthe disease. The aim of this study, which was conducted in Brazil, was to analyze the efficacy of fluralanerin the treatment of demodicosis in dogs. Fifteen dogs with generalized demodicosis that were diagnosedwith Demodex sp. mites from skin scraping were included. All animals were treated with fluralaner at adose of 25 mg/kg, following the manufacturer’s recommendations for the treatment of ectoparasites.The effectiveness of the treatment was evaluated based on clinical improvement of the animals andthe time required to obtain two consecutive negative skin scrapes 30 days apart (parasitological cure).The main clinical signs observed were alopecia (100%; 15/15); erythema (86.7%; 10/15); and hypotrichosis,papule, crusts, hyperpigmentation, and hyperkeratosis (26.7%; 4/15). Of the 15 animals evaluated, two ofthem were excluded for not returning for the second evaluation in 60 days, although they had the firstnegative skin scrape. After 30 days, six (46.2%) from 13 animals that concluded the study presented thefirst negative skin scraping. At the end of the study, all dogs presented parasitological cure and clinicalimprovement, except for three animals. One for developing atopic dermatitis and two that lived in ananimal shelter. In conclusion, a single oral dose of fluralaner is effective in the treatment of generalizeddemodicosis in dogs.Demodiciose é uma dermatopatia parasitária, decorrente da proliferação excessiva de ácaros do gêneroDemodex. A doença apresenta alta ocorrência na clínica de animais de companhia, apesar dos recentesavanços no tratamento da doença. O objetivo deste estudo controlado, realizado no Brasil, foi reportara eficácia do fluralaner, no tratamento da demodiciose em cães. Foram incluídos 15 cães apresentandodemodiciose generalizada, diagnosticados com ácaros do gênero Demodex, a partir do raspado cutâneo.Todos os animais foram tratados com fluralaner na dose de 25 mg/kg, seguindo as recomendaçõesdo fabricante para o tratamento de ectoparasitos. A eficácia do tratamento foi avaliada pela melhoraclínica dos animais e o tempo necessário para a obtenção de dois raspados negativos consecutivoscom intervalo de 30 dias (cura parasitológica). Os principais sinais clínicos observados foram alopecia(100%; 15/15); eritema (86,7%; 10/15); e hipotricose, pápulas, crostas, hiperpigmentação e hiperqueratose(26,7%; 4/15). Dos 15 animais avaliados, dois deles foram excluídos do estudo por não retornarem para asegunda avaliao em 60 dias, embora tivessem apresentado um raspado negativo. Após 30 dias, dos13 animais que concluíram o estudo, (46,2%; 6/13) apresentaram o primeiro raspado negativo. Ao final doperíodo experimental, todos os animais apresentaram cura parasitológica e melhora clínica, exceto emtrês animais, um por apresentar atopia posteriormente e outros dois casos, cujo animais eram oriundosde abrigo. Conclui-se que que uma única dose oral do fluralaner é efetiva no tratamento da demodiciosegeneralizada em cães.Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.2019-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionpeer reviewedAvaliado pelos paresapplication/pdfhttps://rbmv.org/BJVM/article/view/101710.29374/2527-2179.bjvm101719Brazilian Journal of Veterinary Medicine; Vol. 41 No. 1 (2019); e101719Revista Brasileira de Medicina Veterinária; v. 41 n. 1 (2019); e1017192527-21790100-2430reponame:Brazilian Journal of Veterinary Medicineinstname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)instacron:SBMVenghttps://rbmv.org/BJVM/article/view/1017/964Copyright (c) 2019 Natália Lôres Lopes, Flavia Clare Goulart Carvalho, Renata Berman, Marília Alves Machado, Carolina de Moraes Barbalho Trivisol-Medeiros, Julio Israel Fernandesinfo:eu-repo/semantics/openAccessLopes, Natália LôresCarvalho, Flavia Clare GoulartBerman, RenataMachado, Marília AlvesTrivisol-Medeiros, Carolina de Moraes Barbalho Fernandes, Julio Israel2020-12-23T17:24:50Zoai:ojs.rbmv.org:article/1017Revistahttps://rbmv.org/BJVMONGhttps://rbmv.org/BJVM/oaicontato.rbmv@gmail.com2527-21790100-2430opendoar:2020-12-23T17:24:50Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)false
dc.title.none.fl_str_mv Efficacy of fluralaner against canine generalized demodicosis
Eficácia do fluralaner contra demodiciose canina generalizada
title Efficacy of fluralaner against canine generalized demodicosis
spellingShingle Efficacy of fluralaner against canine generalized demodicosis
Lopes, Natália Lôres
cães
acaricida
isoxazolina
dogs
acaricidal
isoxazolines
title_short Efficacy of fluralaner against canine generalized demodicosis
title_full Efficacy of fluralaner against canine generalized demodicosis
title_fullStr Efficacy of fluralaner against canine generalized demodicosis
title_full_unstemmed Efficacy of fluralaner against canine generalized demodicosis
title_sort Efficacy of fluralaner against canine generalized demodicosis
author Lopes, Natália Lôres
author_facet Lopes, Natália Lôres
Carvalho, Flavia Clare Goulart
Berman, Renata
Machado, Marília Alves
Trivisol-Medeiros, Carolina de Moraes Barbalho
Fernandes, Julio Israel
author_role author
author2 Carvalho, Flavia Clare Goulart
Berman, Renata
Machado, Marília Alves
Trivisol-Medeiros, Carolina de Moraes Barbalho
Fernandes, Julio Israel
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Natália Lôres
Carvalho, Flavia Clare Goulart
Berman, Renata
Machado, Marília Alves
Trivisol-Medeiros, Carolina de Moraes Barbalho
Fernandes, Julio Israel
dc.subject.por.fl_str_mv cães
acaricida
isoxazolina
dogs
acaricidal
isoxazolines
topic cães
acaricida
isoxazolina
dogs
acaricidal
isoxazolines
description Demodicosis is a parasitic dermatopathy, resulting from the excessive proliferation of Demodex mites. The rateat which this disease is encountered in the pet clinic is high, despite recent advances in the treatment ofthe disease. The aim of this study, which was conducted in Brazil, was to analyze the efficacy of fluralanerin the treatment of demodicosis in dogs. Fifteen dogs with generalized demodicosis that were diagnosedwith Demodex sp. mites from skin scraping were included. All animals were treated with fluralaner at adose of 25 mg/kg, following the manufacturer’s recommendations for the treatment of ectoparasites.The effectiveness of the treatment was evaluated based on clinical improvement of the animals andthe time required to obtain two consecutive negative skin scrapes 30 days apart (parasitological cure).The main clinical signs observed were alopecia (100%; 15/15); erythema (86.7%; 10/15); and hypotrichosis,papule, crusts, hyperpigmentation, and hyperkeratosis (26.7%; 4/15). Of the 15 animals evaluated, two ofthem were excluded for not returning for the second evaluation in 60 days, although they had the firstnegative skin scrape. After 30 days, six (46.2%) from 13 animals that concluded the study presented thefirst negative skin scraping. At the end of the study, all dogs presented parasitological cure and clinicalimprovement, except for three animals. One for developing atopic dermatitis and two that lived in ananimal shelter. In conclusion, a single oral dose of fluralaner is effective in the treatment of generalizeddemodicosis in dogs.
publishDate 2019
dc.date.none.fl_str_mv 2019-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
peer reviewed
Avaliado pelos pares
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rbmv.org/BJVM/article/view/1017
10.29374/2527-2179.bjvm101719
url https://rbmv.org/BJVM/article/view/1017
identifier_str_mv 10.29374/2527-2179.bjvm101719
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rbmv.org/BJVM/article/view/1017/964
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
publisher.none.fl_str_mv Sociedade de Medicina Veterinária do Estado do Rio de Janeiro.
dc.source.none.fl_str_mv Brazilian Journal of Veterinary Medicine; Vol. 41 No. 1 (2019); e101719
Revista Brasileira de Medicina Veterinária; v. 41 n. 1 (2019); e101719
2527-2179
0100-2430
reponame:Brazilian Journal of Veterinary Medicine
instname:Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron:SBMV
instname_str Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
instacron_str SBMV
institution SBMV
reponame_str Brazilian Journal of Veterinary Medicine
collection Brazilian Journal of Veterinary Medicine
repository.name.fl_str_mv Brazilian Journal of Veterinary Medicine - Sociedade de Medicina Veterinária do Estado do Rio de Janeiro (SOMVERJ)
repository.mail.fl_str_mv contato.rbmv@gmail.com
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