Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva

Detalhes bibliográficos
Autor(a) principal: Menezes, Maria José
Data de Publicação: 2008
Outros Autores: Costa, Dirceu Joaquim, Clarêncio, Jorge, Miranda, José Carlos, Barral, Aldina Maria Prado, Barral-Netto, Manoel, Brodskyn, Claudia Ida, Oliveira, Camila Indiani de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://www.repositorio.ufba.br/ri/handle/ri/6257
Resumo: p. 1-8
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spelling Menezes, Maria JoséCosta, Dirceu JoaquimClarêncio, JorgeMiranda, José CarlosBarral, Aldina Maria PradoBarral-Netto, ManoelBrodskyn, Claudia IdaOliveira, Camila Indiani deMenezes, Maria JoséCosta, Dirceu JoaquimClarêncio, JorgeMiranda, José CarlosBarral, Aldina Maria PradoBarral-Netto, ManoelBrodskyn, Claudia IdaOliveira, Camila Indiani de2012-06-29T13:19:03Z2012-06-29T13:19:03Z20081471-2172http://www.repositorio.ufba.br/ri/handle/ri/6257v. 9, n. 12p. 1-8Background: Sand fly saliva contains potent and complex pharmacologic molecules that are able to modulate the host's hemostatic, inflammatory, and immune systems. In this study, we evaluated the effects of salivary gland sonicate (SGS) of Lutzomyia intermedia, the natural vector of Leishmania braziliensis, on monocytes obtained from the peripheral blood mononuclear cells (PBMC) of healthy volunteers. We investigated the effects of sand fly saliva on cytokine production and surface molecule expression of LPS-stimulated human monocytes uninfected or infected with L. braziliensis. Results: Pre-treatment of non-infected human monocytes with L. intermedia SGS followed by LPSstimulation led to a significant decrease in IL-10 production accompanied by a significant increase in CD86, CD80, and HLA-DR expression. Pre-treatment with SGS followed by LPS stimulation and L. braziliensis infection led to a significant increase in TNF-α, IL-6, and IL-8 production without significant alterations in co-stimulatory molecule expression. However, pre-treatment with L. intermedia SGS did not result in significant changes in the infection rate of human monocytes. Conclusion: Our data indicate that L. intermedia saliva is able to modulate monocyte response, and, although this modulation is dissociated from enhanced infection with L. braziliensis, it may be associated with successful parasitism.Submitted by JURANDI DE SOUZA SILVA (jssufba@hotmail.com) on 2012-06-29T13:19:03Z No. of bitstreams: 1 C__Documents and Settings_rep...t.default_Cache_3_8C_459AEd01.pdf: 374262 bytes, checksum: ad4e02ad2d10b0bf881b5ce6d31e9ad9 (MD5)Made available in DSpace on 2012-06-29T13:19:03Z (GMT). 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dc.title.pt_BR.fl_str_mv Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
dc.title.alternative.pt_BR.fl_str_mv BMC Immunology
title Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
spellingShingle Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
Menezes, Maria José
title_short Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
title_full Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
title_fullStr Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
title_full_unstemmed Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
title_sort Immunomodulation of human monocytes following exposure to Lutzomyia intermedia saliva
author Menezes, Maria José
author_facet Menezes, Maria José
Costa, Dirceu Joaquim
Clarêncio, Jorge
Miranda, José Carlos
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
author_role author
author2 Costa, Dirceu Joaquim
Clarêncio, Jorge
Miranda, José Carlos
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Menezes, Maria José
Costa, Dirceu Joaquim
Clarêncio, Jorge
Miranda, José Carlos
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
Menezes, Maria José
Costa, Dirceu Joaquim
Clarêncio, Jorge
Miranda, José Carlos
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
description p. 1-8
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2012-06-29T13:19:03Z
dc.date.available.fl_str_mv 2012-06-29T13:19:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.repositorio.ufba.br/ri/handle/ri/6257
dc.identifier.issn.none.fl_str_mv 1471-2172
dc.identifier.number.pt_BR.fl_str_mv v. 9, n. 12
identifier_str_mv 1471-2172
v. 9, n. 12
url http://www.repositorio.ufba.br/ri/handle/ri/6257
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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