Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II)
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Tipo de documento: | Tese |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFG |
Texto Completo: | http://repositorio.bc.ufg.br/tede/handle/tede/11320 |
Resumo: | In this work, three new coordination compounds were synthesized with the divalent metal ions of calcium, iron and nickel associated with the drug Ciprofibrato (Cpf). This is an important drug used to treat dyslipidemia. The synthesis of the coordination compounds occurred by direct precipitation after mixing the solution of the Cpf binder in the solution containing the bivalent metal ion, in a ratio of 2 mmol: 1 mmol (binder / metal) in aqueous medium at room temperature. We also obtained the sodium salt by neutralization reaction with aqueous sodium hydroxide solution at room temperature. All compounds obtained are unpublished and were characterized using powder X-ray diffraction techniques (XRD), scanning electron microscopy (SEM), thermogravimetry (TGA), study of gases released using TGA coupled to mid-infrared absorption spectroscopy FTIR, thermal analysis differential (DTA), differential scanning calorimetry (DSC), FTIR, Raman spectroscopy and hydrogen nuclear magnetic resonance (1H NMR). The results showed that the sodium salt and the calcium complex presented crystalline form with micrometric crystallites while the iron and nickel compounds are amorphous and made up of nanoparticle clusters. The thermogravimetric analysis allowed to suggest the minimum formula of the compounds, NaCpf, Ca(Cpf)2·H2O, Fe(Cpf)2·H2O e Ni(Cpf)2·1,5H2O, and to present information on melting temperature, thermal stability, degree of hydration, thermal decomposition steps. The identification of gases released during heating and the residues formed was carried out. Through the analysis of the FTIR, Raman and 1H NMR spectra, we obtained important information in relation to the site and type of coordination of the ligand with the metal ions. The great interest in these compounds, in addition to the novelty, is mainly due to their potential double application, acting simultaneously in the treatment of dyslipidemia and carrying essential metals to combat their deficiency in the body. |
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Leles, Maria Inês Gonçalveshttp://lattes.cnpq.br/1614912440064013Carvalho, Jesiel Freitashttp://lattes.cnpq.br/5841291496427516Leles, Maria Inês GonçalvesOliveira, Cecilia Maria Alves deFernandes, Nedja SuelyIonashiro, Elias YukiOliveira, Sérgio Botelho dehttp://lattes.cnpq.br/6800985000083786Matos, Lucyene Nascimento2021-04-30T16:04:22Z2021-04-30T16:04:22Z2021-02-10MATOS, L. N. Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II). 2021. 91 f. Tese (Doutorado em Química) - Universidade Federal de Goiás, Goiânia, 2021.http://repositorio.bc.ufg.br/tede/handle/tede/11320In this work, three new coordination compounds were synthesized with the divalent metal ions of calcium, iron and nickel associated with the drug Ciprofibrato (Cpf). This is an important drug used to treat dyslipidemia. The synthesis of the coordination compounds occurred by direct precipitation after mixing the solution of the Cpf binder in the solution containing the bivalent metal ion, in a ratio of 2 mmol: 1 mmol (binder / metal) in aqueous medium at room temperature. We also obtained the sodium salt by neutralization reaction with aqueous sodium hydroxide solution at room temperature. All compounds obtained are unpublished and were characterized using powder X-ray diffraction techniques (XRD), scanning electron microscopy (SEM), thermogravimetry (TGA), study of gases released using TGA coupled to mid-infrared absorption spectroscopy FTIR, thermal analysis differential (DTA), differential scanning calorimetry (DSC), FTIR, Raman spectroscopy and hydrogen nuclear magnetic resonance (1H NMR). The results showed that the sodium salt and the calcium complex presented crystalline form with micrometric crystallites while the iron and nickel compounds are amorphous and made up of nanoparticle clusters. The thermogravimetric analysis allowed to suggest the minimum formula of the compounds, NaCpf, Ca(Cpf)2·H2O, Fe(Cpf)2·H2O e Ni(Cpf)2·1,5H2O, and to present information on melting temperature, thermal stability, degree of hydration, thermal decomposition steps. The identification of gases released during heating and the residues formed was carried out. Through the analysis of the FTIR, Raman and 1H NMR spectra, we obtained important information in relation to the site and type of coordination of the ligand with the metal ions. The great interest in these compounds, in addition to the novelty, is mainly due to their potential double application, acting simultaneously in the treatment of dyslipidemia and carrying essential metals to combat their deficiency in the body.Neste trabalho foram sintetizados três novos compostos de coordenação com os íons metálicos bivalentes de cálcio, ferro e níquel associados ao fármaco Ciprofibrato (Cpf). Esse é um importante fármaco usado no tratamento de dislipidemias. A síntese dos compostos de coordenação ocorreu por precipitação direta após mistura da solução do ligante Cpf na solução contendo o íon metálico bivalente, em proporção 2 mmol: 1 mmol (ligante / metal) em meio aquoso a temperatura ambiente. Obtivemos também o sal de sódio por reação de neutralização com solução aquosa de hidróxido de sódio a temperatura ambiente. Todos os compostos obtidos são inéditos e foram caracterizados utilizando as técnicas de difração de raios X pelo método do pó (DRX), microscopia eletrônica de varredura (MEV), termogravimetria (TGA), estudo dos gases liberados usando TGA acoplada ao FTIR, análise térmica diferencial (DTA), calorimetria exploratória diferencial (DSC), espectroscopia de absorção no infravermelho médio (FTIR), espectroscopia Raman e ressonância magnética nuclear de hidrogênio (RMN 1H). Os resultados mostraram que o sal de sódio e o complexo de cálcio apresentaram forma cristalina com cristalitos micrométricos enquanto os compostos de ferro e níquel são amorfos e constituídos por aglomerados de nanopartículas. A análise Termogravimétrica permitiu sugerir a fórmula mínima dos compostos, NaCpf, Ca(Cpf)2·H2O, Fe(Cpf)2·H2O e Ni(Cpf)2·1,5H2O, e apresentar informações sobre temperatura de fusão, estabilidade térmica, grau de hidratação, etapas de decomposição térmica. Foi realizado a identificação dos gases liberados durante aquecimento e dos resíduos formados. Por meio da análise dos espectros de FTIR, Raman e RMN 1H obtivemos informações importantes em relação ao sítio e tipo de coordenação do ligante com os íons metálicos. O grande interesse nesses compostos, além do ineditismo, se deve principalmente à sua potencial dupla aplicação, atuando simultaneamente no tratamento de dislipidemias e carreando metais essenciais para combater a deficiência deles no organismo.Submitted by Franciele Moreira (francielemoreyra@gmail.com) on 2021-04-30T14:50:23Z No. of bitstreams: 2 license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Tese - Lucyene Nascimento Matos - 2021.pdf: 10209585 bytes, checksum: 937ee09adcea28728ce2391540a1770a (MD5)Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2021-04-30T16:04:22Z (GMT) No. of bitstreams: 2 license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Tese - Lucyene Nascimento Matos - 2021.pdf: 10209585 bytes, checksum: 937ee09adcea28728ce2391540a1770a (MD5)Made available in DSpace on 2021-04-30T16:04:22Z (GMT). No. of bitstreams: 2 license_rdf: 805 bytes, checksum: 4460e5956bc1d1639be9ae6146a50347 (MD5) Tese - Lucyene Nascimento Matos - 2021.pdf: 10209585 bytes, checksum: 937ee09adcea28728ce2391540a1770a (MD5) Previous issue date: 2021-02-10porUniversidade Federal de GoiásPrograma de Pós-graduação em Química (IQ)UFGBrasilInstituto de Química - IQ (RG)Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCompostos metálicos de coordenaçãoCiprofibratoSíntese por precipitaçãoPropriedades térmicas e estruturaisAplicações farmacêuticasCoordinating metal compoundsCiprofibratePrecipitation synthesisThermal and structural propertiesPharmaceutical applicationsCIENCIAS EXATAS E DA TERRA::QUIMICASíntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II)Synthesis and characterization of Ciprofibrate coordination compounds with Ca (II), Fe (II) and Ni (II)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesis8150050050029190reponame:Repositório Institucional da UFGinstname:Universidade Federal de Goiás (UFG)instacron:UFGLICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.bc.ufg.br/tede/bitstreams/c529ad68-f8c7-4a48-93e5-81cca3d8f57a/download8a4605be74aa9ea9d79846c1fba20a33MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8805http://repositorio.bc.ufg.br/tede/bitstreams/6ceafc4e-1ba6-48ae-925c-8d8c19b41db3/download4460e5956bc1d1639be9ae6146a50347MD52ORIGINALTese - Lucyene Nascimento Matos - 2021.pdfTese - Lucyene Nascimento Matos - 2021.pdfapplication/pdf10209585http://repositorio.bc.ufg.br/tede/bitstreams/b1dfb411-9ee0-4f7e-8d53-bc59b24f8566/download937ee09adcea28728ce2391540a1770aMD53tede/113202021-04-30 13:04:22.674http://creativecommons.org/licenses/by-nc-nd/4.0/Attribution-NonCommercial-NoDerivatives 4.0 Internationalopen.accessoai:repositorio.bc.ufg.br:tede/11320http://repositorio.bc.ufg.br/tedeRepositório InstitucionalPUBhttp://repositorio.bc.ufg.br/oai/requesttasesdissertacoes.bc@ufg.bropendoar:2021-04-30T16:04:22Repositório Institucional da UFG - Universidade Federal de Goiás (UFG)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 |
dc.title.pt_BR.fl_str_mv |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
dc.title.alternative.eng.fl_str_mv |
Synthesis and characterization of Ciprofibrate coordination compounds with Ca (II), Fe (II) and Ni (II) |
title |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
spellingShingle |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) Matos, Lucyene Nascimento Compostos metálicos de coordenação Ciprofibrato Síntese por precipitação Propriedades térmicas e estruturais Aplicações farmacêuticas Coordinating metal compounds Ciprofibrate Precipitation synthesis Thermal and structural properties Pharmaceutical applications CIENCIAS EXATAS E DA TERRA::QUIMICA |
title_short |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
title_full |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
title_fullStr |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
title_full_unstemmed |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
title_sort |
Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II) |
author |
Matos, Lucyene Nascimento |
author_facet |
Matos, Lucyene Nascimento |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Leles, Maria Inês Gonçalves |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/1614912440064013 |
dc.contributor.advisor-co1.fl_str_mv |
Carvalho, Jesiel Freitas |
dc.contributor.advisor-co1Lattes.fl_str_mv |
http://lattes.cnpq.br/5841291496427516 |
dc.contributor.referee1.fl_str_mv |
Leles, Maria Inês Gonçalves |
dc.contributor.referee2.fl_str_mv |
Oliveira, Cecilia Maria Alves de |
dc.contributor.referee3.fl_str_mv |
Fernandes, Nedja Suely |
dc.contributor.referee4.fl_str_mv |
Ionashiro, Elias Yuki |
dc.contributor.referee5.fl_str_mv |
Oliveira, Sérgio Botelho de |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/6800985000083786 |
dc.contributor.author.fl_str_mv |
Matos, Lucyene Nascimento |
contributor_str_mv |
Leles, Maria Inês Gonçalves Carvalho, Jesiel Freitas Leles, Maria Inês Gonçalves Oliveira, Cecilia Maria Alves de Fernandes, Nedja Suely Ionashiro, Elias Yuki Oliveira, Sérgio Botelho de |
dc.subject.por.fl_str_mv |
Compostos metálicos de coordenação Ciprofibrato Síntese por precipitação Propriedades térmicas e estruturais Aplicações farmacêuticas |
topic |
Compostos metálicos de coordenação Ciprofibrato Síntese por precipitação Propriedades térmicas e estruturais Aplicações farmacêuticas Coordinating metal compounds Ciprofibrate Precipitation synthesis Thermal and structural properties Pharmaceutical applications CIENCIAS EXATAS E DA TERRA::QUIMICA |
dc.subject.eng.fl_str_mv |
Coordinating metal compounds Ciprofibrate Precipitation synthesis Thermal and structural properties Pharmaceutical applications |
dc.subject.cnpq.fl_str_mv |
CIENCIAS EXATAS E DA TERRA::QUIMICA |
description |
In this work, three new coordination compounds were synthesized with the divalent metal ions of calcium, iron and nickel associated with the drug Ciprofibrato (Cpf). This is an important drug used to treat dyslipidemia. The synthesis of the coordination compounds occurred by direct precipitation after mixing the solution of the Cpf binder in the solution containing the bivalent metal ion, in a ratio of 2 mmol: 1 mmol (binder / metal) in aqueous medium at room temperature. We also obtained the sodium salt by neutralization reaction with aqueous sodium hydroxide solution at room temperature. All compounds obtained are unpublished and were characterized using powder X-ray diffraction techniques (XRD), scanning electron microscopy (SEM), thermogravimetry (TGA), study of gases released using TGA coupled to mid-infrared absorption spectroscopy FTIR, thermal analysis differential (DTA), differential scanning calorimetry (DSC), FTIR, Raman spectroscopy and hydrogen nuclear magnetic resonance (1H NMR). The results showed that the sodium salt and the calcium complex presented crystalline form with micrometric crystallites while the iron and nickel compounds are amorphous and made up of nanoparticle clusters. The thermogravimetric analysis allowed to suggest the minimum formula of the compounds, NaCpf, Ca(Cpf)2·H2O, Fe(Cpf)2·H2O e Ni(Cpf)2·1,5H2O, and to present information on melting temperature, thermal stability, degree of hydration, thermal decomposition steps. The identification of gases released during heating and the residues formed was carried out. Through the analysis of the FTIR, Raman and 1H NMR spectra, we obtained important information in relation to the site and type of coordination of the ligand with the metal ions. The great interest in these compounds, in addition to the novelty, is mainly due to their potential double application, acting simultaneously in the treatment of dyslipidemia and carrying essential metals to combat their deficiency in the body. |
publishDate |
2021 |
dc.date.accessioned.fl_str_mv |
2021-04-30T16:04:22Z |
dc.date.available.fl_str_mv |
2021-04-30T16:04:22Z |
dc.date.issued.fl_str_mv |
2021-02-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/doctoralThesis |
format |
doctoralThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MATOS, L. N. Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II). 2021. 91 f. Tese (Doutorado em Química) - Universidade Federal de Goiás, Goiânia, 2021. |
dc.identifier.uri.fl_str_mv |
http://repositorio.bc.ufg.br/tede/handle/tede/11320 |
identifier_str_mv |
MATOS, L. N. Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II). 2021. 91 f. Tese (Doutorado em Química) - Universidade Federal de Goiás, Goiânia, 2021. |
url |
http://repositorio.bc.ufg.br/tede/handle/tede/11320 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.program.fl_str_mv |
81 |
dc.relation.confidence.fl_str_mv |
500 500 500 |
dc.relation.department.fl_str_mv |
29 |
dc.relation.cnpq.fl_str_mv |
190 |
dc.rights.driver.fl_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.publisher.program.fl_str_mv |
Programa de Pós-graduação em Química (IQ) |
dc.publisher.initials.fl_str_mv |
UFG |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Instituto de Química - IQ (RG) |
publisher.none.fl_str_mv |
Universidade Federal de Goiás |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFG instname:Universidade Federal de Goiás (UFG) instacron:UFG |
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UFG |
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UFG |
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