Síntese e caracterização de compostos de coordenação do Ciprofibrato com Ca (II), Fe (II) e Ni (II)

• Autor(a) principal: Matos, Lucyene Nascimento
• Data de Publicação: 2021
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Biblioteca Digital de Teses e Dissertações da UFG
• Texto Completo: http://repositorio.bc.ufg.br/tede/handle/tede/11320
• topic: Compostos metálicos de coordenação; Ciprofibrato; Síntese por precipitação; Propriedades térmicas e estruturais; Aplicações farmacêuticas; Coordinating metal compounds; Ciprofibrate; Precipitation synthesis; Thermal and structural properties; Pharmaceutical applications; CIENCIAS EXATAS E DA TERRA::QUIMICA

In this work, three new coordination compounds were synthesized with the divalent metal ions of calcium, iron and nickel associated with the drug Ciprofibrato (Cpf). This is an important drug used to treat dyslipidemia. The synthesis of the coordination compounds occurred by direct precipitation after mixing the solution of the Cpf binder in the solution containing the bivalent metal ion, in a ratio of 2 mmol: 1 mmol (binder / metal) in aqueous medium at room temperature. We also obtained the sodium salt by neutralization reaction with aqueous sodium hydroxide solution at room temperature. All compounds obtained are unpublished and were characterized using powder X-ray diffraction techniques (XRD), scanning electron microscopy (SEM), thermogravimetry (TGA), study of gases released using TGA coupled to mid-infrared absorption spectroscopy FTIR, thermal analysis differential (DTA), differential scanning calorimetry (DSC), FTIR, Raman spectroscopy and hydrogen nuclear magnetic resonance (1H NMR). The results showed that the sodium salt and the calcium complex presented crystalline form with micrometric crystallites while the iron and nickel compounds are amorphous and made up of nanoparticle clusters. The thermogravimetric analysis allowed to suggest the minimum formula of the compounds, NaCpf, Ca(Cpf)2·H2O, Fe(Cpf)2·H2O e Ni(Cpf)2·1,5H2O, and to present information on melting temperature, thermal stability, degree of hydration, thermal decomposition steps. The identification of gases released during heating and the residues formed was carried out. Through the analysis of the FTIR, Raman and 1H NMR spectra, we obtained important information in relation to the site and type of coordination of the ligand with the metal ions. The great interest in these compounds, in addition to the novelty, is mainly due to their potential double application, acting simultaneously in the treatment of dyslipidemia and carrying essential metals to combat their deficiency in the body.