Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFOP |
Texto Completo: | http://www.repositorio.ufop.br/handle/123456789/9158 https://doi.org/10.1016/j.bmc.2016.12.018 |
Resumo: | Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10), and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1b expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events. |
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Bandeira, Ana Carla BaltharSilva, Rafaella Cecília daRossoni Júnior, Joamyr VictorFigueiredo, Vivian PaulinoSilva, André Talvani Pedrosa daCangussú, Silvia DantasBezerra, Frank SilvaCosta, Daniela Caldeira2017-11-17T13:27:43Z2017-11-17T13:27:43Z2017BANDEIRA, A. C. B. et al. Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bioorganic & Medicinal Chemistry, v. 25, p. 1057-1065, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089616310525>. Acesso em: 15 set. 2017.0968-0896http://www.repositorio.ufop.br/handle/123456789/9158https://doi.org/10.1016/j.bmc.2016.12.018Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10), and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1b expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events.O periódico Bioorganic & Medicinal Chemistry concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4210821115986.info:eu-repo/semantics/openAccessRedox imbalanceInflammationLycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleengreponame:Repositório Institucional da UFOPinstname:Universidade Federal de Ouro Preto (UFOP)instacron:UFOPLICENSElicense.txtlicense.txttext/plain; charset=utf-8924http://www.repositorio.ufop.br/bitstream/123456789/9158/2/license.txt62604f8d955274beb56c80ce1ee5dcaeMD52ORIGINALARTIGO_LycopenePretreatmentImproves.pdfARTIGO_LycopenePretreatmentImproves.pdfapplication/pdf1285107http://www.repositorio.ufop.br/bitstream/123456789/9158/1/ARTIGO_LycopenePretreatmentImproves.pdf2b7dcb1090751d016e92564c7bd7e5dcMD51123456789/91582020-02-20 05:43:50.543oai:localhost: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ório InstitucionalPUBhttp://www.repositorio.ufop.br/oai/requestrepositorio@ufop.edu.bropendoar:32332020-02-20T10:43:50Repositório Institucional da UFOP - Universidade Federal de Ouro Preto (UFOP)false |
dc.title.pt_BR.fl_str_mv |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
title |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
spellingShingle |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bandeira, Ana Carla Balthar Redox imbalance Inflammation |
title_short |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
title_full |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
title_fullStr |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
title_full_unstemmed |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
title_sort |
Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. |
author |
Bandeira, Ana Carla Balthar |
author_facet |
Bandeira, Ana Carla Balthar Silva, Rafaella Cecília da Rossoni Júnior, Joamyr Victor Figueiredo, Vivian Paulino Silva, André Talvani Pedrosa da Cangussú, Silvia Dantas Bezerra, Frank Silva Costa, Daniela Caldeira |
author_role |
author |
author2 |
Silva, Rafaella Cecília da Rossoni Júnior, Joamyr Victor Figueiredo, Vivian Paulino Silva, André Talvani Pedrosa da Cangussú, Silvia Dantas Bezerra, Frank Silva Costa, Daniela Caldeira |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Bandeira, Ana Carla Balthar Silva, Rafaella Cecília da Rossoni Júnior, Joamyr Victor Figueiredo, Vivian Paulino Silva, André Talvani Pedrosa da Cangussú, Silvia Dantas Bezerra, Frank Silva Costa, Daniela Caldeira |
dc.subject.por.fl_str_mv |
Redox imbalance Inflammation |
topic |
Redox imbalance Inflammation |
description |
Acetaminophen (APAP) is an antipyretic and analgesic drug that, in high doses, leads to severe liver injury and potentially death. Oxidative stress is an important event in APAP overdose. Researchers are looking for natural antioxidants with the potential to mitigate the harmful effects of reactive oxygen species in different models. Lycopene has been widely studied for its antioxidant properties. The aim of this study was to evaluate the antioxidant potential of lycopene pretreatment in APAP-induced liver injury in C57BL/6 mice. C57BL/6 male mice were divided into the following groups: control (C); sunflower oil (CO); acetaminophen 500 mg/kg (APAP); acetaminophen 500 mg/kg + lycopene 10 mg/kg (APAP + L10), and acetaminophen 500 mg/kg + lycopene 100 mg/kg (APAP + L100). Mice were pretreated with lycopene for 14 consecutive days prior to APAP overdose. Analyses of blood serum and livers were performed. Lycopene was able to improve redox imbalance, decrease thiobarbituric acid reactive species level, and increase CAT and GSH levels. In addition, it decreased the IL-1b expression and the activity of MMP-2. This study revealed that preventive lycopene consumption in C57BL/6 mice can attenuate the effects of APAP-induced liver injury. Furthermore, by improving the redox state, and thus indicating its potential antioxidant effect, lycopene was also shown to have an influence on inflammatory events. |
publishDate |
2017 |
dc.date.accessioned.fl_str_mv |
2017-11-17T13:27:43Z |
dc.date.available.fl_str_mv |
2017-11-17T13:27:43Z |
dc.date.issued.fl_str_mv |
2017 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BANDEIRA, A. C. B. et al. Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bioorganic & Medicinal Chemistry, v. 25, p. 1057-1065, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089616310525>. Acesso em: 15 set. 2017. |
dc.identifier.uri.fl_str_mv |
http://www.repositorio.ufop.br/handle/123456789/9158 |
dc.identifier.issn.none.fl_str_mv |
0968-0896 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.bmc.2016.12.018 |
identifier_str_mv |
BANDEIRA, A. C. B. et al. Lycopene pretreatment improves hepatotoxicity induced by acetaminophen in C57BL/6 mice. Bioorganic & Medicinal Chemistry, v. 25, p. 1057-1065, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S0968089616310525>. Acesso em: 15 set. 2017. 0968-0896 |
url |
http://www.repositorio.ufop.br/handle/123456789/9158 https://doi.org/10.1016/j.bmc.2016.12.018 |
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eng |
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