Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla

Detalhes bibliográficos
Autor(a) principal: Nonaka, Cassiano Francisco Weege
Data de Publicação: 2009
Outros Autores: Goulart Filho, João Augusto Vianna, Miguel, Márcia Cristina da Costa, Souza, Lélia Batista de, Pinto, Leão Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/49571
https://doi.org/10.1016/j.prp.2009.01.004
Resumo: 2009
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spelling Nonaka, Cassiano Francisco WeegeGoulart Filho, João Augusto ViannaMiguel, Márcia Cristina da CostaSouza, Lélia Batista dePinto, Leão Pereira2022-10-14T19:01:04Z2009NONAKA, Cassiano Francisco Weege et al. Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla. Pathology, Research and Practice, v. 205, n. 7, p. 458-465, 2009.https://repositorio.ufrn.br/handle/123456789/49571https://doi.org/10.1016/j.prp.2009.01.004ElsevierOdontogenic myxomaDental germMatrix metalloproteinaseImmunohistochemistryImmunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papillainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2009The aim of this study was to compare the immunohistochemical expression of matrix metalloproteinases (MMPs) 1, 2, and 9 in odontogenic myxomas and dental germ papillae. Twelve cases of odontogenic myxoma and eight tooth germ specimens were selected for analysis of the immunohistochemical expression and the pattern of distribution of MMPs 1, 2, and 9 in extracellular matrix (ECM), as well as of the number of MMP-positive cells. MMP-2 was expressed only in the ECM of myxomas (p<0.05). No significant difference was observed between ECM immunoreactivity for MMP-9 in myxomas and dental papillae (p>0.05). MMP-1 immunoreactivity was detected in most myxoma cases at a proportion similar to that observed in dental papillae (p>0.05). A significant difference was observed in the number of immunoreactive cells in myxomas (p<0.05), MMP-1 being present at higher proportions than MMPs 2 and 9. There was a gradient in the expression of MMPs in the ECM and in neoplastic cells of odontogenic myxomas, with higher immunoreactivity to MMP-1 and lower immunoreactivity to MMP-9. Taken together, our results suggest the existence of a coordinated mechanism between MMPs 1, 2, and 9 that aimed at the efficient degradation of extracellular matrix in odontogenic myxomas.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALImmunohistochemical expression of matrix.pdfImmunohistochemical expression of matrix.pdfhttp://www.sciencedirect.com/science/article/pii/S0344033809000314application/pdf457271https://repositorio.ufrn.br/bitstream/123456789/49571/1/Immunohistochemical%20expression%20of%20matrix.pdfbeef78b419b497124b9791a38ccf7501MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/49571/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/495712024-03-19 01:01:19.702oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-19T04:01:19Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
title Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
spellingShingle Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
Nonaka, Cassiano Francisco Weege
Odontogenic myxoma
Dental germ
Matrix metalloproteinase
Immunohistochemistry
title_short Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
title_full Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
title_fullStr Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
title_full_unstemmed Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
title_sort Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
author Nonaka, Cassiano Francisco Weege
author_facet Nonaka, Cassiano Francisco Weege
Goulart Filho, João Augusto Vianna
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
author_role author
author2 Goulart Filho, João Augusto Vianna
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Nonaka, Cassiano Francisco Weege
Goulart Filho, João Augusto Vianna
Miguel, Márcia Cristina da Costa
Souza, Lélia Batista de
Pinto, Leão Pereira
dc.subject.por.fl_str_mv Odontogenic myxoma
Dental germ
Matrix metalloproteinase
Immunohistochemistry
topic Odontogenic myxoma
Dental germ
Matrix metalloproteinase
Immunohistochemistry
description 2009
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2022-10-14T19:01:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv NONAKA, Cassiano Francisco Weege et al. Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla. Pathology, Research and Practice, v. 205, n. 7, p. 458-465, 2009.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/49571
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.prp.2009.01.004
identifier_str_mv NONAKA, Cassiano Francisco Weege et al. Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla. Pathology, Research and Practice, v. 205, n. 7, p. 458-465, 2009.
url https://repositorio.ufrn.br/handle/123456789/49571
https://doi.org/10.1016/j.prp.2009.01.004
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
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institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
bitstream.url.fl_str_mv https://repositorio.ufrn.br/bitstream/123456789/49571/1/Immunohistochemical%20expression%20of%20matrix.pdf
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