Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/49571 https://doi.org/10.1016/j.prp.2009.01.004 |
Resumo: | 2009 |
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Nonaka, Cassiano Francisco WeegeGoulart Filho, João Augusto ViannaMiguel, Márcia Cristina da CostaSouza, Lélia Batista dePinto, Leão Pereira2022-10-14T19:01:04Z2009NONAKA, Cassiano Francisco Weege et al. Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla. Pathology, Research and Practice, v. 205, n. 7, p. 458-465, 2009.https://repositorio.ufrn.br/handle/123456789/49571https://doi.org/10.1016/j.prp.2009.01.004ElsevierOdontogenic myxomaDental germMatrix metalloproteinaseImmunohistochemistryImmunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papillainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2009The aim of this study was to compare the immunohistochemical expression of matrix metalloproteinases (MMPs) 1, 2, and 9 in odontogenic myxomas and dental germ papillae. Twelve cases of odontogenic myxoma and eight tooth germ specimens were selected for analysis of the immunohistochemical expression and the pattern of distribution of MMPs 1, 2, and 9 in extracellular matrix (ECM), as well as of the number of MMP-positive cells. MMP-2 was expressed only in the ECM of myxomas (p<0.05). No significant difference was observed between ECM immunoreactivity for MMP-9 in myxomas and dental papillae (p>0.05). MMP-1 immunoreactivity was detected in most myxoma cases at a proportion similar to that observed in dental papillae (p>0.05). A significant difference was observed in the number of immunoreactive cells in myxomas (p<0.05), MMP-1 being present at higher proportions than MMPs 2 and 9. There was a gradient in the expression of MMPs in the ECM and in neoplastic cells of odontogenic myxomas, with higher immunoreactivity to MMP-1 and lower immunoreactivity to MMP-9. Taken together, our results suggest the existence of a coordinated mechanism between MMPs 1, 2, and 9 that aimed at the efficient degradation of extracellular matrix in odontogenic myxomas.info:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALImmunohistochemical expression of matrix.pdfImmunohistochemical expression of matrix.pdfhttp://www.sciencedirect.com/science/article/pii/S0344033809000314application/pdf457271https://repositorio.ufrn.br/bitstream/123456789/49571/1/Immunohistochemical%20expression%20of%20matrix.pdfbeef78b419b497124b9791a38ccf7501MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repositorio.ufrn.br/bitstream/123456789/49571/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52123456789/495712024-03-19 01:01:19.702oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2024-03-19T04:01:19Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
title |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
spellingShingle |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla Nonaka, Cassiano Francisco Weege Odontogenic myxoma Dental germ Matrix metalloproteinase Immunohistochemistry |
title_short |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
title_full |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
title_fullStr |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
title_full_unstemmed |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
title_sort |
Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla |
author |
Nonaka, Cassiano Francisco Weege |
author_facet |
Nonaka, Cassiano Francisco Weege Goulart Filho, João Augusto Vianna Miguel, Márcia Cristina da Costa Souza, Lélia Batista de Pinto, Leão Pereira |
author_role |
author |
author2 |
Goulart Filho, João Augusto Vianna Miguel, Márcia Cristina da Costa Souza, Lélia Batista de Pinto, Leão Pereira |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Nonaka, Cassiano Francisco Weege Goulart Filho, João Augusto Vianna Miguel, Márcia Cristina da Costa Souza, Lélia Batista de Pinto, Leão Pereira |
dc.subject.por.fl_str_mv |
Odontogenic myxoma Dental germ Matrix metalloproteinase Immunohistochemistry |
topic |
Odontogenic myxoma Dental germ Matrix metalloproteinase Immunohistochemistry |
description |
2009 |
publishDate |
2009 |
dc.date.issued.fl_str_mv |
2009 |
dc.date.accessioned.fl_str_mv |
2022-10-14T19:01:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
NONAKA, Cassiano Francisco Weege et al. Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla. Pathology, Research and Practice, v. 205, n. 7, p. 458-465, 2009. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/49571 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.prp.2009.01.004 |
identifier_str_mv |
NONAKA, Cassiano Francisco Weege et al. Immunohistochemical expression of matrix metalloproteinases 1, 2 and 9 in odontogenic myxoma and dental germ papilla. Pathology, Research and Practice, v. 205, n. 7, p. 458-465, 2009. |
url |
https://repositorio.ufrn.br/handle/123456789/49571 https://doi.org/10.1016/j.prp.2009.01.004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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Repositório Institucional da UFRN |
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