Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study

• Autor(a) principal: Scorza, Fulvio Alexandre [UNIFESP]
• Data de Publicação: 1998
• Outros Autores: Sanabria, ERG, Calderazzo, Lineu [UNIFESP], Cavalheiro, Esper Abrão [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/25961; http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x
• topic: interictal; pilocarpine; epilepsy; deoxyglucose; rat

Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.