Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study
Autor(a) principal: | |
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Data de Publicação: | 1998 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/25961 http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x |
Resumo: | Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals. |
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Scorza, Fulvio Alexandre [UNIFESP]Sanabria, ERGCalderazzo, Lineu [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:30:40Z2016-01-24T12:30:40Z1998-10-01Epilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998.0013-9580http://repositorio.unifesp.br/handle/11600/25961http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x10.1111/j.1528-1157.1998.tb01288.xWOS:000076280500002Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals.UNIFESP, EPM, BR-04023900 São Paulo, BrazilUNIFESP, EPM, BR-04023900 São Paulo, BrazilWeb of Science1041-1045engLippincott Williams & WilkinsEpilepsiainterictalpilocarpineepilepsydeoxyglucoseratGlucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/259612023-02-14 15:23:16.721metadata only accessoai:repositorio.unifesp.br:11600/25961Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-02-14T18:23:16Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
title |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
spellingShingle |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study Scorza, Fulvio Alexandre [UNIFESP] interictal pilocarpine epilepsy deoxyglucose rat |
title_short |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
title_full |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
title_fullStr |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
title_full_unstemmed |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
title_sort |
Glucose utilization during interictal intervals in an epilepsy model induced by pilocarpine: A qualitative study |
author |
Scorza, Fulvio Alexandre [UNIFESP] |
author_facet |
Scorza, Fulvio Alexandre [UNIFESP] Sanabria, ERG Calderazzo, Lineu [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
author_role |
author |
author2 |
Sanabria, ERG Calderazzo, Lineu [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Scorza, Fulvio Alexandre [UNIFESP] Sanabria, ERG Calderazzo, Lineu [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] |
dc.subject.eng.fl_str_mv |
interictal pilocarpine epilepsy deoxyglucose rat |
topic |
interictal pilocarpine epilepsy deoxyglucose rat |
description |
Purpose: Interictal intervals in pilocarpine-induced chronic epilepsy are characterized by apparent normal electrographic activity and longer sleep periods or drowsiness or both. Sparse information exists concerning the neural network activity during these seizure-free intervals. in our research, all [C-14]2-deoxy-D-glucose (2DG) autoradiographic technique was used to investigate interictal changes in the metabolism of the epileptic rat brain.Methods: Epileptic mts were monitored by video-EEG for similar to 120 days, with [C-14]2DG injected after a seizure-free interval of greater than or equal to 24 h.Results: Autoradiographic analysis revealed an increase in glucose utilization by several brain regions; the most consistent increase was found in the lateral posterior thalamic nucleus and prerectal region.Conclusions: These findings suggest that the lateral posterior thalamic nucleus and the prerectal region may be involved in cerebral circuits inhibiting epileptic activity during interictal intervals. |
publishDate |
1998 |
dc.date.issued.fl_str_mv |
1998-10-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:30:40Z |
dc.date.available.fl_str_mv |
2016-01-24T12:30:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Epilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/25961 http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x |
dc.identifier.issn.none.fl_str_mv |
0013-9580 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1528-1157.1998.tb01288.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000076280500002 |
identifier_str_mv |
Epilepsia. Philadelphia: Lippincott Williams & Wilkins, v. 39, n. 10, p. 1041-1045, 1998. 0013-9580 10.1111/j.1528-1157.1998.tb01288.x WOS:000076280500002 |
url |
http://repositorio.unifesp.br/handle/11600/25961 http://dx.doi.org/10.1111/j.1528-1157.1998.tb01288.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Epilepsia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1041-1045 |
dc.publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
publisher.none.fl_str_mv |
Lippincott Williams & Wilkins |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764191005671424 |