Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri

Detalhes bibliográficos
Autor(a) principal: Zena, Lucas A. [UNESP]
Data de Publicação: 2015
Outros Autores: Gargaglioni, Luciane H. [UNESP], Bícego, Kênia Cardoso [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.sciencedirect.com/science/article/pii/S1095643314002025
http://hdl.handle.net/11449/126091
Resumo: For an adequate blood supply to support metabolic demands, vertebrates regulate blood pressure to maintain sufficient perfusion to avoid ischemia and other tissue damage like edema. Using a pharmacological approach (phenylephrine and sodium nitroprusside) we investigated baroreflex sensitivity at 15, 25, and 30 °C in toads Rhinella schneideri. Baroreflex sensitivity presented a high thermal dependence (Q10 = 1.9–4.1), and the HR– baroreflex curve was shifted up and to the right as temperature increased from 15 to 30 °C. Baroreflex variables, namely, HR range, gain50 (maximal gain) and normalized gain50 increased 206, 235, and 160% from 15 to 30 °C, respectively. The cardiac limb of the baroreflex response to pharmacological treatments was significantly blunted after full autonomic blockade. In addition, there was a clear baroreflex–HR response mainly to hypotension at all three temperatures tested. These findings indicate that toads present temperature dependence for cardiac limb of the barostatic response and the cardiac baroreflex response in R. schneideri is primarily hypotensive rather than hypertensive as well as crocodilians and mammals. Thus, the cardiac baroreflex compensation to changes in arterial pressure might present different patterns among amphibian species, since the previously reported bradycardic compensation to hypertension in some anurans was not observed in the toad used in the present study.
id UNSP_3edce4839b91d7b5a01fc4b2d1aa079c
oai_identifier_str oai:repositorio.unesp.br:11449/126091
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideriBaroreflex sensitivityAmphibiansBlood pressureSodium nitroprussidePhenylephrineFor an adequate blood supply to support metabolic demands, vertebrates regulate blood pressure to maintain sufficient perfusion to avoid ischemia and other tissue damage like edema. Using a pharmacological approach (phenylephrine and sodium nitroprusside) we investigated baroreflex sensitivity at 15, 25, and 30 °C in toads Rhinella schneideri. Baroreflex sensitivity presented a high thermal dependence (Q10 = 1.9–4.1), and the HR– baroreflex curve was shifted up and to the right as temperature increased from 15 to 30 °C. Baroreflex variables, namely, HR range, gain50 (maximal gain) and normalized gain50 increased 206, 235, and 160% from 15 to 30 °C, respectively. The cardiac limb of the baroreflex response to pharmacological treatments was significantly blunted after full autonomic blockade. In addition, there was a clear baroreflex–HR response mainly to hypotension at all three temperatures tested. These findings indicate that toads present temperature dependence for cardiac limb of the barostatic response and the cardiac baroreflex response in R. schneideri is primarily hypotensive rather than hypertensive as well as crocodilians and mammals. Thus, the cardiac baroreflex compensation to changes in arterial pressure might present different patterns among amphibian species, since the previously reported bradycardic compensation to hypertension in some anurans was not observed in the toad used in the present study.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Jaboticabal, Via de acesso Prof. Paulo D Castellane, Rural, CEP 14884-900, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Agrárias e Veterinárias de Jaboticabal, Jaboticabal, Via de acesso Prof. Paulo D Castellane, Rural, CEP 14884-900, SP, BrasilFAPESP: 2008/57712-4FAPESP: 2012/17379-0Universidade Estadual Paulista (Unesp)Zena, Lucas A. [UNESP]Gargaglioni, Luciane H. [UNESP]Bícego, Kênia Cardoso [UNESP]2015-08-06T16:13:55Z2015-08-06T16:13:55Z2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article81-88http://www.sciencedirect.com/science/article/pii/S1095643314002025Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, v. 179, p. 81-88, 2015.1095-6433http://hdl.handle.net/11449/12609110.1016/j.cbpa.2014.09.027585045346899449701699673780714260000-0003-1810-5313[3]Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengComparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology2.2580,836info:eu-repo/semantics/openAccess2024-06-06T18:41:42Zoai:repositorio.unesp.br:11449/126091Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:33:49.050378Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
title Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
spellingShingle Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
Zena, Lucas A. [UNESP]
Baroreflex sensitivity
Amphibians
Blood pressure
Sodium nitroprusside
Phenylephrine
title_short Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
title_full Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
title_fullStr Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
title_full_unstemmed Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
title_sort Temperature effects on baroreflex control of heart rate in the toad, Rhinella schneideri
author Zena, Lucas A. [UNESP]
author_facet Zena, Lucas A. [UNESP]
Gargaglioni, Luciane H. [UNESP]
Bícego, Kênia Cardoso [UNESP]
author_role author
author2 Gargaglioni, Luciane H. [UNESP]
Bícego, Kênia Cardoso [UNESP]
author2_role author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Zena, Lucas A. [UNESP]
Gargaglioni, Luciane H. [UNESP]
Bícego, Kênia Cardoso [UNESP]
dc.subject.por.fl_str_mv Baroreflex sensitivity
Amphibians
Blood pressure
Sodium nitroprusside
Phenylephrine
topic Baroreflex sensitivity
Amphibians
Blood pressure
Sodium nitroprusside
Phenylephrine
description For an adequate blood supply to support metabolic demands, vertebrates regulate blood pressure to maintain sufficient perfusion to avoid ischemia and other tissue damage like edema. Using a pharmacological approach (phenylephrine and sodium nitroprusside) we investigated baroreflex sensitivity at 15, 25, and 30 °C in toads Rhinella schneideri. Baroreflex sensitivity presented a high thermal dependence (Q10 = 1.9–4.1), and the HR– baroreflex curve was shifted up and to the right as temperature increased from 15 to 30 °C. Baroreflex variables, namely, HR range, gain50 (maximal gain) and normalized gain50 increased 206, 235, and 160% from 15 to 30 °C, respectively. The cardiac limb of the baroreflex response to pharmacological treatments was significantly blunted after full autonomic blockade. In addition, there was a clear baroreflex–HR response mainly to hypotension at all three temperatures tested. These findings indicate that toads present temperature dependence for cardiac limb of the barostatic response and the cardiac baroreflex response in R. schneideri is primarily hypotensive rather than hypertensive as well as crocodilians and mammals. Thus, the cardiac baroreflex compensation to changes in arterial pressure might present different patterns among amphibian species, since the previously reported bradycardic compensation to hypertension in some anurans was not observed in the toad used in the present study.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-06T16:13:55Z
2015-08-06T16:13:55Z
2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.sciencedirect.com/science/article/pii/S1095643314002025
Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, v. 179, p. 81-88, 2015.
1095-6433
http://hdl.handle.net/11449/126091
10.1016/j.cbpa.2014.09.027
5850453468994497
0169967378071426
0000-0003-1810-5313[3]
url http://www.sciencedirect.com/science/article/pii/S1095643314002025
http://hdl.handle.net/11449/126091
identifier_str_mv Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology, v. 179, p. 81-88, 2015.
1095-6433
10.1016/j.cbpa.2014.09.027
5850453468994497
0169967378071426
0000-0003-1810-5313[3]
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
2.258
0,836
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 81-88
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128947482787840