Introducing polymer conductance in diagnostically relevant transduction

Detalhes bibliográficos
Autor(a) principal: Baradoke, Ausra
Data de Publicação: 2021
Outros Autores: Santos, Adriano [UNESP], Bueno, Paulo R. [UNESP], Davis, Jason J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.bios.2020.112705
http://hdl.handle.net/11449/208114
Resumo: In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.
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spelling Introducing polymer conductance in diagnostically relevant transductionBiosensorsC-reactive proteinMolecular scale conductancePoint-of-careReagentlessIn this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Innovate UKDepartment of Chemistry University of Oxford, South Parks Road, Oxford OX1 3QZInstitute of Chemistry São Paulo State University (UNESP), São PauloInstitute of Chemistry São Paulo State University (UNESP), São PauloUniversity of OxfordUniversidade Estadual Paulista (Unesp)Baradoke, AusraSantos, Adriano [UNESP]Bueno, Paulo R. [UNESP]Davis, Jason J.2021-06-25T11:06:33Z2021-06-25T11:06:33Z2021-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bios.2020.112705Biosensors and Bioelectronics, v. 172.1873-42350956-5663http://hdl.handle.net/11449/20811410.1016/j.bios.2020.1127052-s2.0-85095432701Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiosensors and Bioelectronicsinfo:eu-repo/semantics/openAccess2021-10-23T18:56:43Zoai:repositorio.unesp.br:11449/208114Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T18:56:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Introducing polymer conductance in diagnostically relevant transduction
title Introducing polymer conductance in diagnostically relevant transduction
spellingShingle Introducing polymer conductance in diagnostically relevant transduction
Baradoke, Ausra
Biosensors
C-reactive protein
Molecular scale conductance
Point-of-care
Reagentless
title_short Introducing polymer conductance in diagnostically relevant transduction
title_full Introducing polymer conductance in diagnostically relevant transduction
title_fullStr Introducing polymer conductance in diagnostically relevant transduction
title_full_unstemmed Introducing polymer conductance in diagnostically relevant transduction
title_sort Introducing polymer conductance in diagnostically relevant transduction
author Baradoke, Ausra
author_facet Baradoke, Ausra
Santos, Adriano [UNESP]
Bueno, Paulo R. [UNESP]
Davis, Jason J.
author_role author
author2 Santos, Adriano [UNESP]
Bueno, Paulo R. [UNESP]
Davis, Jason J.
author2_role author
author
author
dc.contributor.none.fl_str_mv University of Oxford
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Baradoke, Ausra
Santos, Adriano [UNESP]
Bueno, Paulo R. [UNESP]
Davis, Jason J.
dc.subject.por.fl_str_mv Biosensors
C-reactive protein
Molecular scale conductance
Point-of-care
Reagentless
topic Biosensors
C-reactive protein
Molecular scale conductance
Point-of-care
Reagentless
description In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T11:06:33Z
2021-06-25T11:06:33Z
2021-01-15
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.bios.2020.112705
Biosensors and Bioelectronics, v. 172.
1873-4235
0956-5663
http://hdl.handle.net/11449/208114
10.1016/j.bios.2020.112705
2-s2.0-85095432701
url http://dx.doi.org/10.1016/j.bios.2020.112705
http://hdl.handle.net/11449/208114
identifier_str_mv Biosensors and Bioelectronics, v. 172.
1873-4235
0956-5663
10.1016/j.bios.2020.112705
2-s2.0-85095432701
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biosensors and Bioelectronics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1797789262507147264

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