Introducing polymer conductance in diagnostically relevant transduction
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bios.2020.112705 http://hdl.handle.net/11449/208114 |
Resumo: | In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention. |
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Repositório Institucional da UNESP |
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2946 |
spelling |
Introducing polymer conductance in diagnostically relevant transductionBiosensorsC-reactive proteinMolecular scale conductancePoint-of-careReagentlessIn this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Innovate UKDepartment of Chemistry University of Oxford, South Parks Road, Oxford OX1 3QZInstitute of Chemistry São Paulo State University (UNESP), São PauloInstitute of Chemistry São Paulo State University (UNESP), São PauloUniversity of OxfordUniversidade Estadual Paulista (Unesp)Baradoke, AusraSantos, Adriano [UNESP]Bueno, Paulo R. [UNESP]Davis, Jason J.2021-06-25T11:06:33Z2021-06-25T11:06:33Z2021-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.bios.2020.112705Biosensors and Bioelectronics, v. 172.1873-42350956-5663http://hdl.handle.net/11449/20811410.1016/j.bios.2020.1127052-s2.0-85095432701Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBiosensors and Bioelectronicsinfo:eu-repo/semantics/openAccess2021-10-23T18:56:43Zoai:repositorio.unesp.br:11449/208114Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T18:56:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Introducing polymer conductance in diagnostically relevant transduction |
title |
Introducing polymer conductance in diagnostically relevant transduction |
spellingShingle |
Introducing polymer conductance in diagnostically relevant transduction Baradoke, Ausra Biosensors C-reactive protein Molecular scale conductance Point-of-care Reagentless |
title_short |
Introducing polymer conductance in diagnostically relevant transduction |
title_full |
Introducing polymer conductance in diagnostically relevant transduction |
title_fullStr |
Introducing polymer conductance in diagnostically relevant transduction |
title_full_unstemmed |
Introducing polymer conductance in diagnostically relevant transduction |
title_sort |
Introducing polymer conductance in diagnostically relevant transduction |
author |
Baradoke, Ausra |
author_facet |
Baradoke, Ausra Santos, Adriano [UNESP] Bueno, Paulo R. [UNESP] Davis, Jason J. |
author_role |
author |
author2 |
Santos, Adriano [UNESP] Bueno, Paulo R. [UNESP] Davis, Jason J. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
University of Oxford Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Baradoke, Ausra Santos, Adriano [UNESP] Bueno, Paulo R. [UNESP] Davis, Jason J. |
dc.subject.por.fl_str_mv |
Biosensors C-reactive protein Molecular scale conductance Point-of-care Reagentless |
topic |
Biosensors C-reactive protein Molecular scale conductance Point-of-care Reagentless |
description |
In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T11:06:33Z 2021-06-25T11:06:33Z 2021-01-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bios.2020.112705 Biosensors and Bioelectronics, v. 172. 1873-4235 0956-5663 http://hdl.handle.net/11449/208114 10.1016/j.bios.2020.112705 2-s2.0-85095432701 |
url |
http://dx.doi.org/10.1016/j.bios.2020.112705 http://hdl.handle.net/11449/208114 |
identifier_str_mv |
Biosensors and Bioelectronics, v. 172. 1873-4235 0956-5663 10.1016/j.bios.2020.112705 2-s2.0-85095432701 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Biosensors and Bioelectronics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964398801911808 |