Influência dos primeiros mil dias de vida em crianças com sintomas de asma aos 6-7 anos de idade em Palhoça – Santa Catarina

• Autor(a) principal: Santos, Karoliny dos
• Data de Publicação: 2018
• Tipo de documento: Tese
• Idioma: por
• Título da fonte: Repositório Universitário da Ânima (RUNA)
• Texto Completo: https://repositorio.animaeducacao.com.br/handle/ANIMA/3150
• topic: Asma; Criança; Fatores de risco; Fatores de proteção

Introduction: The first thousand days of life are a critical stage for the development of respiratory and immune systems. Many events occurring in this period may be associated with asthma in childhood. Objective: To analyze which factors occurring between conception and the first two years of life are associated with symptoms and severity of asthma symptoms in children aged 6-7 years in Palhoça, Santa Catarina. Methods: Population-based case-control study. A questionnaire with questions related to the initial period of life was applied with mothers whose children lived and were regularly enrolled in schools in Palhoça. Symptoms and severity of asthma symptoms were assessed by the International Study of Asthma and Allergies in Childhood questionnaire. Multiple logistic regressions were performed according to a hierarchical framework, considering the complex dynamic of asthma and potential interaction between different levels of determination. Results: 820 children were included. Asthma symptoms were reported in 19.7% of the children and 13.7% had severe symptoms of the disease. Exposures which were associated with an increase in the odds of asthma symptoms at 6-7 years of age were: receiving social welfare from Bolsa Família, family history of asthma, vaginal discharge during pregnancy, neonatal hyperbilirrubinemia, anemia, and intestinal parasite infection in the first two years of life. Intended pregnancy reduced the odds of asthma symptoms. The severity of the symptoms was associated with a family history of asthma, neonatal hyperbilurrubinemia, and anemia in the first two years. Intended pregnancy and fifth minute APGAR ≥ 8 decreased the odds of severe symptoms. Conclusion: Family, economic and individual conditions related to the first thousand days of life are associated with the manifestation of childhood asthma symptoms.