Prevalência do Adenovírus 36, relação com a obesidade humana e com alterações fisiopatológicas: uma revisão sistemática

• Autor(a) principal: Fernandes, Jaime da Silva
• Data de Publicação: 2019
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Universitário da Ânima (RUNA)
• Texto Completo: https://repositorio.animaeducacao.com.br/handle/ANIMA/15149
• topic: Tecido adiposo; Adenovírus 36; Ad-36; AdV36; Adiposidade; Humano; Obesidade

Introduction: Obesity has complex etiology and includes biological factors. Studies demonstrate adipogenic effect and metabolic alterations of human adenovirus subtype 36 (AdV36). There is significant variation in the results of the studies with respect to the prevalence of AdV36 and the effects in humans. Thus, it is necessary to summarize the data released so far. Objectives: Carry out a systematic review to verify the prevalence of AdV36 infection and its relation with human obesity and with metabolic alterations. Methods: Systematic review of the literature using the Preferred Reporting Items for Systematic Reviews and Metanalysis (PRISMA). Case-control studies, cohorts, cross-sectional and clinical trials were included, based on the Medline, Embase, LILACS and SciElo databases. Results: Thirty-five studies were evaluated, of which seven were case-control, six were cohorts, six were transverse, three were mixed drawings, two were classified as longitudinal, eight had no precise definition of the design, and one had a clinical trial. The prevalence of AdV36 varied from 3.9% to 63.6% (with obesity) and from 0% to 51,6% (without obesity). There was statistical evidence of association of AdV36 with weight gain, obesity diagnosis or metabolic alterations in 25 studies, but in 6 studies no association of obesity-related phenomena was observed, and in 3 were not performed or described measures of association. One of the articles showed that AdV36 infection was inversely related, with adenovirus being a protective factor for obesity. Conclusion: The evaluation of the 35 studies suggests a causal effect of viral infection with obesity and metabolic factors. There was great variability of the diagnostic methods of AdV36, of the associated factors studied and of the age groups and profiles of the populations studied. There is a need for further studies, better standardization of the designs, and increase the sample. Keywords: Obesity, adipose tissue, adenovirus 36, Ad-36, AdV36, adiposity, human