Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401539 |
Resumo: | ABSTRACT The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin. |
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Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomescapsaicinliposomesurinary incontinenceintravesical administrationABSTRACT The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin.Academia Brasileira de Ciências2016-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401539Anais da Academia Brasileira de Ciências v.88 n.3 2016reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201620150309info:eu-repo/semantics/openAccessCIRINO,LORENA M.D.VERGNE,DAVIANE M.C.SANTANA,PATRÍCIA F.ALMEIDA,ENRIK DECOSTA,LUIZ P. DAALBUQUERQUE-JÚNIOR,RICARDO L.C. DELIMA-VERDE,ISABEL B.PADILHA,FRANCINE F.CARDOSO,JULIANA C.eng2016-09-12T00:00:00Zoai:scielo:S0001-37652016000401539Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2016-09-12T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
title |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
spellingShingle |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes CIRINO,LORENA M.D. capsaicin liposomes urinary incontinence intravesical administration |
title_short |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
title_full |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
title_fullStr |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
title_full_unstemmed |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
title_sort |
Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes |
author |
CIRINO,LORENA M.D. |
author_facet |
CIRINO,LORENA M.D. VERGNE,DAVIANE M.C. SANTANA,PATRÍCIA F. ALMEIDA,ENRIK DE COSTA,LUIZ P. DA ALBUQUERQUE-JÚNIOR,RICARDO L.C. DE LIMA-VERDE,ISABEL B. PADILHA,FRANCINE F. CARDOSO,JULIANA C. |
author_role |
author |
author2 |
VERGNE,DAVIANE M.C. SANTANA,PATRÍCIA F. ALMEIDA,ENRIK DE COSTA,LUIZ P. DA ALBUQUERQUE-JÚNIOR,RICARDO L.C. DE LIMA-VERDE,ISABEL B. PADILHA,FRANCINE F. CARDOSO,JULIANA C. |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
CIRINO,LORENA M.D. VERGNE,DAVIANE M.C. SANTANA,PATRÍCIA F. ALMEIDA,ENRIK DE COSTA,LUIZ P. DA ALBUQUERQUE-JÚNIOR,RICARDO L.C. DE LIMA-VERDE,ISABEL B. PADILHA,FRANCINE F. CARDOSO,JULIANA C. |
dc.subject.por.fl_str_mv |
capsaicin liposomes urinary incontinence intravesical administration |
topic |
capsaicin liposomes urinary incontinence intravesical administration |
description |
ABSTRACT The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401539 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000401539 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201620150309 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.88 n.3 2016 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302863156183040 |