The development and characterization of Propranolol Tablets using Tapioca starch as excipient
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100806 |
Resumo: | Abstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to investigate the potential of TS in the development of POP tablets by means of direct compression. Its evaluation was performed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) relaxometry, scanning electron microscopy (SEM), uniformity of weight, drug content, disintegration, friability, hardness, dissolution test and drug release kinetics. The TS granules were spherical with mean diameter of 10.09 ± 1.85 µm. The XRD, FTIR and NMR suggested physical interaction between TS and POP. The tablets presented average diameter of 1.1 ± 0.0 cm, 0.24 ± 0.02 cm thickness and average weight of 0.544 ± 0.003 g. The hardness of tablets was 10.98 ± 0.31 N and the percentage of friability was 25.74 ± 0.08%. POP was released after 45 min and the release kinetics properly fitted the Hixson-Crowell equation. |
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The development and characterization of Propranolol Tablets using Tapioca starch as excipienttapioca starchpropranololtabletNMR relaxationAbstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to investigate the potential of TS in the development of POP tablets by means of direct compression. Its evaluation was performed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) relaxometry, scanning electron microscopy (SEM), uniformity of weight, drug content, disintegration, friability, hardness, dissolution test and drug release kinetics. The TS granules were spherical with mean diameter of 10.09 ± 1.85 µm. The XRD, FTIR and NMR suggested physical interaction between TS and POP. The tablets presented average diameter of 1.1 ± 0.0 cm, 0.24 ± 0.02 cm thickness and average weight of 0.544 ± 0.003 g. The hardness of tablets was 10.98 ± 0.31 N and the percentage of friability was 25.74 ± 0.08%. POP was released after 45 min and the release kinetics properly fitted the Hixson-Crowell equation.Academia Brasileira de Ciências2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100806Anais da Academia Brasileira de Ciências v.91 n.1 2019reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201920180094info:eu-repo/semantics/openAccessFERNANDES,JULYANE B.M.CELESTINO,MAÍSA T.TAVARES,MARIA I.B.FREITAS,ZAIDA M.F.SANTOS,ELISABETE P. DOSRICCI JÚNIOR,EDUARDOMONTEIRO,MARIANA S.S.B.eng2019-04-16T00:00:00Zoai:scielo:S0001-37652019000100806Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2019-04-16T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
title |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
spellingShingle |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient FERNANDES,JULYANE B.M. tapioca starch propranolol tablet NMR relaxation |
title_short |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
title_full |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
title_fullStr |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
title_full_unstemmed |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
title_sort |
The development and characterization of Propranolol Tablets using Tapioca starch as excipient |
author |
FERNANDES,JULYANE B.M. |
author_facet |
FERNANDES,JULYANE B.M. CELESTINO,MAÍSA T. TAVARES,MARIA I.B. FREITAS,ZAIDA M.F. SANTOS,ELISABETE P. DOS RICCI JÚNIOR,EDUARDO MONTEIRO,MARIANA S.S.B. |
author_role |
author |
author2 |
CELESTINO,MAÍSA T. TAVARES,MARIA I.B. FREITAS,ZAIDA M.F. SANTOS,ELISABETE P. DOS RICCI JÚNIOR,EDUARDO MONTEIRO,MARIANA S.S.B. |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
FERNANDES,JULYANE B.M. CELESTINO,MAÍSA T. TAVARES,MARIA I.B. FREITAS,ZAIDA M.F. SANTOS,ELISABETE P. DOS RICCI JÚNIOR,EDUARDO MONTEIRO,MARIANA S.S.B. |
dc.subject.por.fl_str_mv |
tapioca starch propranolol tablet NMR relaxation |
topic |
tapioca starch propranolol tablet NMR relaxation |
description |
Abstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to investigate the potential of TS in the development of POP tablets by means of direct compression. Its evaluation was performed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) relaxometry, scanning electron microscopy (SEM), uniformity of weight, drug content, disintegration, friability, hardness, dissolution test and drug release kinetics. The TS granules were spherical with mean diameter of 10.09 ± 1.85 µm. The XRD, FTIR and NMR suggested physical interaction between TS and POP. The tablets presented average diameter of 1.1 ± 0.0 cm, 0.24 ± 0.02 cm thickness and average weight of 0.544 ± 0.003 g. The hardness of tablets was 10.98 ± 0.31 N and the percentage of friability was 25.74 ± 0.08%. POP was released after 45 min and the release kinetics properly fitted the Hixson-Crowell equation. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100806 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100806 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201920180094 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.91 n.1 2019 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302867263455232 |