Histological modifications of the rat prostate following transection of somatic and autonomic nerves
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200015 |
Resumo: | It is known that hormones influence significantly the prostate tissue. However, we reported that mating induces an increase in androgen receptors, revealing a neural influence on the gland. These data suggested that somatic afferents (scrotal and genitofemoral nerves) and autonomic efferents (pelvic and hypogastric nerves) could regulate the structure of the prostate. Here we assessed the role of these nerves in maintaining the histology of the gland. Hence, afferent or efferent nerves of male rats were transected. Then, the ventral and dorsolateral regions of the prostate were processed for histology. Results showed that afferent transection affects prostate histology. The alveoli area decreased and increased in the ventral and dorsolateral prostate, respectively. The epithelial cell height increased in both regions. Efferent denervation produced dramatic changes in the prostate gland. The tissue lost its configuration, and the epithelium became scattered and almost vanished. Thus, afferent nerves are responsible for spinal processes pertaining to the trophic control of the prostate, activating its autonomic innervation. Hence, our data imply that innervation seems to be synergic with hormones for the healthy maintenance of the prostate. Thus, it is suggested that some prostate pathologies could be due to the failure of the autonomic neural pathways regulating the gland. |
id |
ABC-1_0e0cb07ac289fa8c04eeef5b35f29756 |
---|---|
oai_identifier_str |
oai:scielo:S0001-37652010000200015 |
network_acronym_str |
ABC-1 |
network_name_str |
Anais da Academia Brasileira de Ciências (Online) |
repository_id_str |
|
spelling |
Histological modifications of the rat prostate following transection of somatic and autonomic nervespelvic nervehypogastric nervegenitofemoral nervescrotal nerveIt is known that hormones influence significantly the prostate tissue. However, we reported that mating induces an increase in androgen receptors, revealing a neural influence on the gland. These data suggested that somatic afferents (scrotal and genitofemoral nerves) and autonomic efferents (pelvic and hypogastric nerves) could regulate the structure of the prostate. Here we assessed the role of these nerves in maintaining the histology of the gland. Hence, afferent or efferent nerves of male rats were transected. Then, the ventral and dorsolateral regions of the prostate were processed for histology. Results showed that afferent transection affects prostate histology. The alveoli area decreased and increased in the ventral and dorsolateral prostate, respectively. The epithelial cell height increased in both regions. Efferent denervation produced dramatic changes in the prostate gland. The tissue lost its configuration, and the epithelium became scattered and almost vanished. Thus, afferent nerves are responsible for spinal processes pertaining to the trophic control of the prostate, activating its autonomic innervation. Hence, our data imply that innervation seems to be synergic with hormones for the healthy maintenance of the prostate. Thus, it is suggested that some prostate pathologies could be due to the failure of the autonomic neural pathways regulating the gland.Academia Brasileira de Ciências2010-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200015Anais da Academia Brasileira de Ciências v.82 n.2 2010reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652010000200015info:eu-repo/semantics/openAccessDiaz,RosauraGarcia,Luis I.Locia,JoseSilva,MilagrosRodriguez,SaraPerez,Cesar A.Aranda-Abreu,Gonzalo E.Manzo,JorgeToledo,RebecaHernandez,Maria Elenaeng2010-06-11T00:00:00Zoai:scielo:S0001-37652010000200015Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2010-06-11T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
title |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
spellingShingle |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves Diaz,Rosaura pelvic nerve hypogastric nerve genitofemoral nerve scrotal nerve |
title_short |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
title_full |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
title_fullStr |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
title_full_unstemmed |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
title_sort |
Histological modifications of the rat prostate following transection of somatic and autonomic nerves |
author |
Diaz,Rosaura |
author_facet |
Diaz,Rosaura Garcia,Luis I. Locia,Jose Silva,Milagros Rodriguez,Sara Perez,Cesar A. Aranda-Abreu,Gonzalo E. Manzo,Jorge Toledo,Rebeca Hernandez,Maria Elena |
author_role |
author |
author2 |
Garcia,Luis I. Locia,Jose Silva,Milagros Rodriguez,Sara Perez,Cesar A. Aranda-Abreu,Gonzalo E. Manzo,Jorge Toledo,Rebeca Hernandez,Maria Elena |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Diaz,Rosaura Garcia,Luis I. Locia,Jose Silva,Milagros Rodriguez,Sara Perez,Cesar A. Aranda-Abreu,Gonzalo E. Manzo,Jorge Toledo,Rebeca Hernandez,Maria Elena |
dc.subject.por.fl_str_mv |
pelvic nerve hypogastric nerve genitofemoral nerve scrotal nerve |
topic |
pelvic nerve hypogastric nerve genitofemoral nerve scrotal nerve |
description |
It is known that hormones influence significantly the prostate tissue. However, we reported that mating induces an increase in androgen receptors, revealing a neural influence on the gland. These data suggested that somatic afferents (scrotal and genitofemoral nerves) and autonomic efferents (pelvic and hypogastric nerves) could regulate the structure of the prostate. Here we assessed the role of these nerves in maintaining the histology of the gland. Hence, afferent or efferent nerves of male rats were transected. Then, the ventral and dorsolateral regions of the prostate were processed for histology. Results showed that afferent transection affects prostate histology. The alveoli area decreased and increased in the ventral and dorsolateral prostate, respectively. The epithelial cell height increased in both regions. Efferent denervation produced dramatic changes in the prostate gland. The tissue lost its configuration, and the epithelium became scattered and almost vanished. Thus, afferent nerves are responsible for spinal processes pertaining to the trophic control of the prostate, activating its autonomic innervation. Hence, our data imply that innervation seems to be synergic with hormones for the healthy maintenance of the prostate. Thus, it is suggested that some prostate pathologies could be due to the failure of the autonomic neural pathways regulating the gland. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200015 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200015 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0001-37652010000200015 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.82 n.2 2010 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302857608167424 |