Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications

Detalhes bibliográficos
Autor(a) principal: JAGANATHAN,SARAVANA KUMAR
Data de Publicação: 2019
Outros Autores: MANI,MOHAN P., SUPRIYANTO,EKO
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300708
Resumo: Abstract: Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.
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spelling Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applicationspolyurethanemegni oilelectrospun scaffoldblood compatibilitytissue engineeringAbstract: Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.Academia Brasileira de Ciências2019-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300708Anais da Academia Brasileira de Ciências v.91 n.2 2019reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201920190018info:eu-repo/semantics/openAccessJAGANATHAN,SARAVANA KUMARMANI,MOHAN P.SUPRIYANTO,EKOeng2019-06-13T00:00:00Zoai:scielo:S0001-37652019000300708Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2019-06-13T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
title Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
spellingShingle Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
JAGANATHAN,SARAVANA KUMAR
polyurethane
megni oil
electrospun scaffold
blood compatibility
tissue engineering
title_short Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
title_full Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
title_fullStr Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
title_full_unstemmed Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
title_sort Blood compatibility assessments of electrospun polyurethane nanocomposites blended with megni oil for tissue engineering applications
author JAGANATHAN,SARAVANA KUMAR
author_facet JAGANATHAN,SARAVANA KUMAR
MANI,MOHAN P.
SUPRIYANTO,EKO
author_role author
author2 MANI,MOHAN P.
SUPRIYANTO,EKO
author2_role author
author
dc.contributor.author.fl_str_mv JAGANATHAN,SARAVANA KUMAR
MANI,MOHAN P.
SUPRIYANTO,EKO
dc.subject.por.fl_str_mv polyurethane
megni oil
electrospun scaffold
blood compatibility
tissue engineering
topic polyurethane
megni oil
electrospun scaffold
blood compatibility
tissue engineering
description Abstract: Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.
publishDate 2019
dc.date.none.fl_str_mv 2019-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300708
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000300708
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201920190018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.91 n.2 2019
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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