Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives

Detalhes bibliográficos
Autor(a) principal: PINHEIRO,LUIZ C.S.
Data de Publicação: 2018
Outros Autores: FEITOSA,LÍVIA M., SILVEIRA,FLÁVIA F. DA, BOECHAT,NUBIA
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301251
Resumo: ABSTRACT According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.
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spelling Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin DerivativesmalariaPlasmodium falciparumartemisininhybridABSTRACT According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.Academia Brasileira de Ciências2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301251Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201820170830info:eu-repo/semantics/openAccessPINHEIRO,LUIZ C.S.FEITOSA,LÍVIA M.SILVEIRA,FLÁVIA F. DABOECHAT,NUBIAeng2018-05-28T00:00:00Zoai:scielo:S0001-37652018000301251Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2018-05-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
title Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
spellingShingle Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
PINHEIRO,LUIZ C.S.
malaria
Plasmodium falciparum
artemisinin
hybrid
title_short Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
title_full Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
title_fullStr Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
title_full_unstemmed Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
title_sort Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
author PINHEIRO,LUIZ C.S.
author_facet PINHEIRO,LUIZ C.S.
FEITOSA,LÍVIA M.
SILVEIRA,FLÁVIA F. DA
BOECHAT,NUBIA
author_role author
author2 FEITOSA,LÍVIA M.
SILVEIRA,FLÁVIA F. DA
BOECHAT,NUBIA
author2_role author
author
author
dc.contributor.author.fl_str_mv PINHEIRO,LUIZ C.S.
FEITOSA,LÍVIA M.
SILVEIRA,FLÁVIA F. DA
BOECHAT,NUBIA
dc.subject.por.fl_str_mv malaria
Plasmodium falciparum
artemisinin
hybrid
topic malaria
Plasmodium falciparum
artemisinin
hybrid
description ABSTRACT According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301251
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301251
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201820170830
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.90 n.1 suppl.2 2018
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
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institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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