The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening

Detalhes bibliográficos
Autor(a) principal: ALVES,GILDA
Data de Publicação: 2020
Outros Autores: CHANTRE,MARIANA, DELMONICO,LUCAS
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700804
Resumo: Abstract Circulating DNA can be released in the biological fluids by a physiological process and by different pathological conditions. The first reports detecting circulating DNA in human plasma date from the late 40s. Even when specific pathological conditions were analyzed, the clinical importance of circulating DNA remained unclear. After PCR introduction, genetic and epigenetic alterations in circulating DNA gained more prominence for understanding the mechanisms of cancer development and progression. Nowadays, the circulating DNA assays are highlighted for their clinical relevance for cancer screening in liquid biopsy. In this review, we described the landscape of studies on circulating DNA isolated from human plasma or serum and the molecular tools used to obtain these findings throughout the 20th century and the current application in cancer.
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spelling The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screeningCanceroncologycirculating DNAliquid biopsyplasmaserumAbstract Circulating DNA can be released in the biological fluids by a physiological process and by different pathological conditions. The first reports detecting circulating DNA in human plasma date from the late 40s. Even when specific pathological conditions were analyzed, the clinical importance of circulating DNA remained unclear. After PCR introduction, genetic and epigenetic alterations in circulating DNA gained more prominence for understanding the mechanisms of cancer development and progression. Nowadays, the circulating DNA assays are highlighted for their clinical relevance for cancer screening in liquid biopsy. In this review, we described the landscape of studies on circulating DNA isolated from human plasma or serum and the molecular tools used to obtain these findings throughout the 20th century and the current application in cancer.Academia Brasileira de Ciências2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700804Anais da Academia Brasileira de Ciências v.92 n.4 2020reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202020200919info:eu-repo/semantics/openAccessALVES,GILDACHANTRE,MARIANADELMONICO,LUCASeng2020-11-12T00:00:00Zoai:scielo:S0001-37652020000700804Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2020-11-12T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
title The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
spellingShingle The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
ALVES,GILDA
Cancer
oncology
circulating DNA
liquid biopsy
plasma
serum
title_short The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
title_full The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
title_fullStr The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
title_full_unstemmed The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
title_sort The contribution of the 20th century discoveries on the circulating DNA as biomarkers for cancer screening
author ALVES,GILDA
author_facet ALVES,GILDA
CHANTRE,MARIANA
DELMONICO,LUCAS
author_role author
author2 CHANTRE,MARIANA
DELMONICO,LUCAS
author2_role author
author
dc.contributor.author.fl_str_mv ALVES,GILDA
CHANTRE,MARIANA
DELMONICO,LUCAS
dc.subject.por.fl_str_mv Cancer
oncology
circulating DNA
liquid biopsy
plasma
serum
topic Cancer
oncology
circulating DNA
liquid biopsy
plasma
serum
description Abstract Circulating DNA can be released in the biological fluids by a physiological process and by different pathological conditions. The first reports detecting circulating DNA in human plasma date from the late 40s. Even when specific pathological conditions were analyzed, the clinical importance of circulating DNA remained unclear. After PCR introduction, genetic and epigenetic alterations in circulating DNA gained more prominence for understanding the mechanisms of cancer development and progression. Nowadays, the circulating DNA assays are highlighted for their clinical relevance for cancer screening in liquid biopsy. In this review, we described the landscape of studies on circulating DNA isolated from human plasma or serum and the molecular tools used to obtain these findings throughout the 20th century and the current application in cancer.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700804
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000700804
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202020200919
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.92 n.4 2020
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
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instname_str Academia Brasileira de Ciências (ABC)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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