Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB

Detalhes bibliográficos
Autor(a) principal: VITOR,NEIMAR
Data de Publicação: 2021
Outros Autores: MEZA,ALISSON, GOMES,ROBERTO S., RAFIQUE,JAMAL, DE LIMA,DÊNIS P., BEATRIZ,ADILSON
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501
Resumo: Abstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C).
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spelling Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BBcytosporonesFriedel–Crafts acylationorganocatalysismethanolysisvitamin CAbstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C).Academia Brasileira de Ciências2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501Anais da Academia Brasileira de Ciências v.93 n.3 2021reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202120201347info:eu-repo/semantics/openAccessVITOR,NEIMARMEZA,ALISSONGOMES,ROBERTO S.RAFIQUE,JAMALDE LIMA,DÊNIS P.BEATRIZ,ADILSONeng2021-06-28T00:00:00Zoai:scielo:S0001-37652021000500501Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2021-06-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
title Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
spellingShingle Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
VITOR,NEIMAR
cytosporones
Friedel–Crafts acylation
organocatalysis
methanolysis
vitamin C
title_short Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
title_full Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
title_fullStr Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
title_full_unstemmed Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
title_sort Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
author VITOR,NEIMAR
author_facet VITOR,NEIMAR
MEZA,ALISSON
GOMES,ROBERTO S.
RAFIQUE,JAMAL
DE LIMA,DÊNIS P.
BEATRIZ,ADILSON
author_role author
author2 MEZA,ALISSON
GOMES,ROBERTO S.
RAFIQUE,JAMAL
DE LIMA,DÊNIS P.
BEATRIZ,ADILSON
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv VITOR,NEIMAR
MEZA,ALISSON
GOMES,ROBERTO S.
RAFIQUE,JAMAL
DE LIMA,DÊNIS P.
BEATRIZ,ADILSON
dc.subject.por.fl_str_mv cytosporones
Friedel–Crafts acylation
organocatalysis
methanolysis
vitamin C
topic cytosporones
Friedel–Crafts acylation
organocatalysis
methanolysis
vitamin C
description Abstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C).
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202120201347
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.93 n.3 2021
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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