Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501 |
Resumo: | Abstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C). |
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Anais da Academia Brasileira de Ciências (Online) |
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Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BBcytosporonesFriedel–Crafts acylationorganocatalysismethanolysisvitamin CAbstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C).Academia Brasileira de Ciências2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501Anais da Academia Brasileira de Ciências v.93 n.3 2021reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202120201347info:eu-repo/semantics/openAccessVITOR,NEIMARMEZA,ALISSONGOMES,ROBERTO S.RAFIQUE,JAMALDE LIMA,DÊNIS P.BEATRIZ,ADILSONeng2021-06-28T00:00:00Zoai:scielo:S0001-37652021000500501Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2021-06-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
title |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
spellingShingle |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB VITOR,NEIMAR cytosporones Friedel–Crafts acylation organocatalysis methanolysis vitamin C |
title_short |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
title_full |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
title_fullStr |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
title_full_unstemmed |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
title_sort |
Straightforward synthesis of cytosporone analogs AMS35AA and AMS35BB |
author |
VITOR,NEIMAR |
author_facet |
VITOR,NEIMAR MEZA,ALISSON GOMES,ROBERTO S. RAFIQUE,JAMAL DE LIMA,DÊNIS P. BEATRIZ,ADILSON |
author_role |
author |
author2 |
MEZA,ALISSON GOMES,ROBERTO S. RAFIQUE,JAMAL DE LIMA,DÊNIS P. BEATRIZ,ADILSON |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
VITOR,NEIMAR MEZA,ALISSON GOMES,ROBERTO S. RAFIQUE,JAMAL DE LIMA,DÊNIS P. BEATRIZ,ADILSON |
dc.subject.por.fl_str_mv |
cytosporones Friedel–Crafts acylation organocatalysis methanolysis vitamin C |
topic |
cytosporones Friedel–Crafts acylation organocatalysis methanolysis vitamin C |
description |
Abstract Cytosporones, a class of octaketide resorcinolic lipids, have drawn the attention of researchers for exhibiting a number of notable biological properties. Herein, we describe routes to synthesize the bioactive synthetic resorcinolic lipids AMS35AA and AMS35BB with excellent overall yields using 3,5-dimethoxybenzoic acid as the starting material. The methods proved remarkably efficient to achieve the target compounds and comprise the synthesis of AMS35AA catalyzed by ascorbic acid (vitamin C). |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500501 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202120201347 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.93 n.3 2021 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302870406037504 |