Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis

Detalhes bibliográficos
Autor(a) principal: COLOMBO,ANA CAROLINE
Data de Publicação: 2015
Outros Autores: RODRIGUES,MARCIO L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301293
Resumo: Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.
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spelling Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosisFungal InfectionsCryptococcusmeningitismeningoencephalitisBrain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.Academia Brasileira de Ciências2015-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301293Anais da Academia Brasileira de Ciências v.87 n.2 suppl.0 2015reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201520140704info:eu-repo/semantics/openAccessCOLOMBO,ANA CAROLINERODRIGUES,MARCIO L.eng2015-09-17T00:00:00Zoai:scielo:S0001-37652015000301293Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2015-09-17T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
spellingShingle Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
COLOMBO,ANA CAROLINE
Fungal Infections
Cryptococcus
meningitis
meningoencephalitis
title_short Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_full Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_fullStr Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_full_unstemmed Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_sort Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
author COLOMBO,ANA CAROLINE
author_facet COLOMBO,ANA CAROLINE
RODRIGUES,MARCIO L.
author_role author
author2 RODRIGUES,MARCIO L.
author2_role author
dc.contributor.author.fl_str_mv COLOMBO,ANA CAROLINE
RODRIGUES,MARCIO L.
dc.subject.por.fl_str_mv Fungal Infections
Cryptococcus
meningitis
meningoencephalitis
topic Fungal Infections
Cryptococcus
meningitis
meningoencephalitis
description Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.
publishDate 2015
dc.date.none.fl_str_mv 2015-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301293
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201520140704
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dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.87 n.2 suppl.0 2015
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
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collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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