Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis

Detalhes bibliográficos
Autor(a) principal: Colombo, Ana Caroline
Data de Publicação: 2015
Outros Autores: Rodrigues, Marcio Lourenço
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/27671
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Pós-Graduação em Química Biológica. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.
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spelling Colombo, Ana CarolineRodrigues, Marcio Lourenço2018-07-26T14:02:15Z2018-07-26T14:02:15Z2015COLOMBO, A. C; RODRIGUES, M. L. Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis. Anais da Academia Brasileira de Ciências, v. 87, n. 2 (suppl.), p. 1293-1309, 2015.1678-2690https://www.arca.fiocruz.br/handle/icict/2767110.1590/0001-3765201520140704engAcademia Brasileira de CiênciasCriptococcoseCérebroFungal colonization of the brain: anatomopathological aspects of neurological cryptococcosisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Pós-Graduação em Química Biológica. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.Brain infection by the fungus Cryptococcus neoformans results in an estimated 500,000 human deaths per annum. Colonization of the central nervous system (CNS) by C. neoformans causes different clinical syndromes that involve interaction of a number of fungal components with distinct brain cells. In this manuscript, our literature review confirmed the notion that the Cryptococcus field is expanding rapidly, but also suggested that studies on neuropathogenesis still represent a small fraction of basic research activity in the field. We therefore discussed anatomical and physiological aspects of the brain during infection by C. neoformans, in addition to mechanisms by which brain resident cells interact with the fungus. This review suggests that multiple efforts are necessary to improve the knowledge on how C. neoformans affects brain cells, in order to enable the generation of new therapeutic tools in a near future.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/27671/1/license.txt425ef259bcb460998407fbfed7c102d0MD51ORIGINALve_Marcio_Rodrigues_CDTS_2015.pdfve_Marcio_Rodrigues_CDTS_2015.pdfapplication/pdf3350834https://www.arca.fiocruz.br/bitstream/icict/27671/2/ve_Marcio_Rodrigues_CDTS_2015.pdf2e27a6d73fc581f0f1ab574e5691e51bMD52TEXTve_Marcio_Rodrigues_CDTS_2015.pdf.txtve_Marcio_Rodrigues_CDTS_2015.pdf.txtExtracted texttext/plain71082https://www.arca.fiocruz.br/bitstream/icict/27671/3/ve_Marcio_Rodrigues_CDTS_2015.pdf.txt3d76aa9b22858bb0794573afe5214a57MD53icict/276712023-01-09 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dc.title.pt_BR.fl_str_mv Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
spellingShingle Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
Colombo, Ana Caroline
Criptococcose
Cérebro
title_short Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_full Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_fullStr Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_full_unstemmed Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
title_sort Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis
author Colombo, Ana Caroline
author_facet Colombo, Ana Caroline
Rodrigues, Marcio Lourenço
author_role author
author2 Rodrigues, Marcio Lourenço
author2_role author
dc.contributor.author.fl_str_mv Colombo, Ana Caroline
Rodrigues, Marcio Lourenço
dc.subject.other.pt_BR.fl_str_mv Criptococcose
Cérebro
topic Criptococcose
Cérebro
description Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Programa de Pós-Graduação em Química Biológica. Instituto de Microbiologia Paulo de Góes. Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2018-07-26T14:02:15Z
dc.date.available.fl_str_mv 2018-07-26T14:02:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv COLOMBO, A. C; RODRIGUES, M. L. Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis. Anais da Academia Brasileira de Ciências, v. 87, n. 2 (suppl.), p. 1293-1309, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/27671
dc.identifier.issn.pt_BR.fl_str_mv 1678-2690
dc.identifier.doi.none.fl_str_mv 10.1590/0001-3765201520140704
identifier_str_mv COLOMBO, A. C; RODRIGUES, M. L. Fungal colonization of the brain: anatomopathological aspects of neurological cryptococcosis. Anais da Academia Brasileira de Ciências, v. 87, n. 2 (suppl.), p. 1293-1309, 2015.
1678-2690
10.1590/0001-3765201520140704
url https://www.arca.fiocruz.br/handle/icict/27671
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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