Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature

Detalhes bibliográficos
Autor(a) principal: Sousa,Cristina P.
Data de Publicação: 2015
Outros Autores: Dias,Isabel R., Lopez-peña,Mónica, Camassa,José A., Lourenço,Paulo J., Judas,Fernando M., Gomes,Manuela E., Reis,Rui L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049
Resumo: Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.
id ABC-1_566003d63219e81a885ff6396e4b7ad7
oai_identifier_str oai:scielo:S0001-37652015000201049
network_acronym_str ABC-1
network_name_str Anais da Academia Brasileira de Ciências (Online)
repository_id_str
spelling Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literaturebone formation markersbone resorption markersdelayed unionfracture healingosteoclast regulatory proteinsnon-union processImaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.Academia Brasileira de Ciências2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049Anais da Academia Brasileira de Ciências v.87 n.2 2015reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201520150008info:eu-repo/semantics/openAccessSousa,Cristina P.Dias,Isabel R.Lopez-peña,MónicaCamassa,José A.Lourenço,Paulo J.Judas,Fernando M.Gomes,Manuela E.Reis,Rui L.eng2016-03-04T00:00:00Zoai:scielo:S0001-37652015000201049Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2016-03-04T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
title Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
spellingShingle Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
Sousa,Cristina P.
bone formation markers
bone resorption markers
delayed union
fracture healing
osteoclast regulatory proteins
non-union process
title_short Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
title_full Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
title_fullStr Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
title_full_unstemmed Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
title_sort Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
author Sousa,Cristina P.
author_facet Sousa,Cristina P.
Dias,Isabel R.
Lopez-peña,Mónica
Camassa,José A.
Lourenço,Paulo J.
Judas,Fernando M.
Gomes,Manuela E.
Reis,Rui L.
author_role author
author2 Dias,Isabel R.
Lopez-peña,Mónica
Camassa,José A.
Lourenço,Paulo J.
Judas,Fernando M.
Gomes,Manuela E.
Reis,Rui L.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sousa,Cristina P.
Dias,Isabel R.
Lopez-peña,Mónica
Camassa,José A.
Lourenço,Paulo J.
Judas,Fernando M.
Gomes,Manuela E.
Reis,Rui L.
dc.subject.por.fl_str_mv bone formation markers
bone resorption markers
delayed union
fracture healing
osteoclast regulatory proteins
non-union process
topic bone formation markers
bone resorption markers
delayed union
fracture healing
osteoclast regulatory proteins
non-union process
description Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.
publishDate 2015
dc.date.none.fl_str_mv 2015-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201520150008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.87 n.2 2015
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
_version_ 1754302861648330752