Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049 |
Resumo: | Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome. |
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Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literaturebone formation markersbone resorption markersdelayed unionfracture healingosteoclast regulatory proteinsnon-union processImaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome.Academia Brasileira de Ciências2015-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049Anais da Academia Brasileira de Ciências v.87 n.2 2015reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201520150008info:eu-repo/semantics/openAccessSousa,Cristina P.Dias,Isabel R.Lopez-peña,MónicaCamassa,José A.Lourenço,Paulo J.Judas,Fernando M.Gomes,Manuela E.Reis,Rui L.eng2016-03-04T00:00:00Zoai:scielo:S0001-37652015000201049Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2016-03-04T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
title |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
spellingShingle |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature Sousa,Cristina P. bone formation markers bone resorption markers delayed union fracture healing osteoclast regulatory proteins non-union process |
title_short |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
title_full |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
title_fullStr |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
title_full_unstemmed |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
title_sort |
Bone turnover markers for early detection of fracture healing disturbances: A review of the scientific literature |
author |
Sousa,Cristina P. |
author_facet |
Sousa,Cristina P. Dias,Isabel R. Lopez-peña,Mónica Camassa,José A. Lourenço,Paulo J. Judas,Fernando M. Gomes,Manuela E. Reis,Rui L. |
author_role |
author |
author2 |
Dias,Isabel R. Lopez-peña,Mónica Camassa,José A. Lourenço,Paulo J. Judas,Fernando M. Gomes,Manuela E. Reis,Rui L. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa,Cristina P. Dias,Isabel R. Lopez-peña,Mónica Camassa,José A. Lourenço,Paulo J. Judas,Fernando M. Gomes,Manuela E. Reis,Rui L. |
dc.subject.por.fl_str_mv |
bone formation markers bone resorption markers delayed union fracture healing osteoclast regulatory proteins non-union process |
topic |
bone formation markers bone resorption markers delayed union fracture healing osteoclast regulatory proteins non-union process |
description |
Imaging techniques are the standard method for assessment of fracture healing processes. However, these methods are perhaps not entirely reliable for early detection of complications, the most frequent of these being delayed union and non-union. A prompt diagnosis of such disorders could prevent prolonged patient distress and disability. Efforts should be directed towards the development of new technologies for improving accuracy in diagnosing complications following bone fractures. The variation in the levels of bone turnover markers (BTMs) have been assessed with regard to there ability to predict impaired fracture healing at an early stage, nevertheless the conclusions of some studies are not consensual. In this article the authors have revised the potential of BTMs as early predictors of prognosis in adult patients presenting traumatic bone fractures but who did not suffer from osteopenia or postmenopausal osteoporosis. The available information from the different studies performed in this field was systematized in order to highlight the most promising BTMs for the assessment of fracture healing outcome. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000201049 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765201520150008 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.87 n.2 2015 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302861648330752 |