Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000700602 |
Resumo: | Abstract Lycopene is a hydrocarbon-carotenoid commonly found in red fruits intake with major function correlated to antioxidative capacity in several pathological conditions, including cancer and cardiovascular diseases. Recently, lycopene has been associated with hematopoiesis, although the effects on B lymphocyte differentiation and antibody production are poorly understood. In this work, the principal aim was to investigate whether lycopene affects B lymphopoiesis and terminal differentiation into plasma cells. Distinct in vivo and in vitro strategies based on lycopene supplementation were used direct in Balb/c mice or in culture systems with cells derived of these mice. In the bone marrow, lycopene expanded B220+IgM- progenitor B cells and B220+IgM+ immature B lymphocytes. In the spleen, lycopene induced terminal CD138+ plasma cell generation. In the blood, we found prominent IgA and low IgM levels after lycopene administration. Interestingly, the pattern of peritoneal IgM+ and IgA+ B cells indicated a significant IgM-to-IgA class switching after lycopene injection. These data indicated that lycopene induces B cell differentiation into IgA-producing plasma cells. Thus, a new cellular function has been attributed to lycopene for B lymphocyte biology and possibly associated with humoral responses and mucosal immunity. |
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Anais da Academia Brasileira de Ciências (Online) |
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Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cellsB lymphocytescell differentiationIgAimmunologyLycopeneAbstract Lycopene is a hydrocarbon-carotenoid commonly found in red fruits intake with major function correlated to antioxidative capacity in several pathological conditions, including cancer and cardiovascular diseases. Recently, lycopene has been associated with hematopoiesis, although the effects on B lymphocyte differentiation and antibody production are poorly understood. In this work, the principal aim was to investigate whether lycopene affects B lymphopoiesis and terminal differentiation into plasma cells. Distinct in vivo and in vitro strategies based on lycopene supplementation were used direct in Balb/c mice or in culture systems with cells derived of these mice. In the bone marrow, lycopene expanded B220+IgM- progenitor B cells and B220+IgM+ immature B lymphocytes. In the spleen, lycopene induced terminal CD138+ plasma cell generation. In the blood, we found prominent IgA and low IgM levels after lycopene administration. Interestingly, the pattern of peritoneal IgM+ and IgA+ B cells indicated a significant IgM-to-IgA class switching after lycopene injection. These data indicated that lycopene induces B cell differentiation into IgA-producing plasma cells. Thus, a new cellular function has been attributed to lycopene for B lymphocyte biology and possibly associated with humoral responses and mucosal immunity.Academia Brasileira de Ciências2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000700602Anais da Academia Brasileira de Ciências v.94 suppl.3 2022reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202220210002info:eu-repo/semantics/openAccessELIAS,MONIQUE B.TEODORO,ANDERSON J.LEMOS,FELIPE S.BERNARDES,EMERSON S.SANTOS,SOFIA N.PACHECO,SIDNEYOLIVEIRA,FELIPE LEITE DEeng2022-09-28T00:00:00Zoai:scielo:S0001-37652022000700602Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2022-09-28T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
title |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
spellingShingle |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells ELIAS,MONIQUE B. B lymphocytes cell differentiation IgA immunology Lycopene |
title_short |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
title_full |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
title_fullStr |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
title_full_unstemmed |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
title_sort |
Lycopene induces bone marrow lymphopoiesis and differentiation of peritoneal IgA-producing cells |
author |
ELIAS,MONIQUE B. |
author_facet |
ELIAS,MONIQUE B. TEODORO,ANDERSON J. LEMOS,FELIPE S. BERNARDES,EMERSON S. SANTOS,SOFIA N. PACHECO,SIDNEY OLIVEIRA,FELIPE LEITE DE |
author_role |
author |
author2 |
TEODORO,ANDERSON J. LEMOS,FELIPE S. BERNARDES,EMERSON S. SANTOS,SOFIA N. PACHECO,SIDNEY OLIVEIRA,FELIPE LEITE DE |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
ELIAS,MONIQUE B. TEODORO,ANDERSON J. LEMOS,FELIPE S. BERNARDES,EMERSON S. SANTOS,SOFIA N. PACHECO,SIDNEY OLIVEIRA,FELIPE LEITE DE |
dc.subject.por.fl_str_mv |
B lymphocytes cell differentiation IgA immunology Lycopene |
topic |
B lymphocytes cell differentiation IgA immunology Lycopene |
description |
Abstract Lycopene is a hydrocarbon-carotenoid commonly found in red fruits intake with major function correlated to antioxidative capacity in several pathological conditions, including cancer and cardiovascular diseases. Recently, lycopene has been associated with hematopoiesis, although the effects on B lymphocyte differentiation and antibody production are poorly understood. In this work, the principal aim was to investigate whether lycopene affects B lymphopoiesis and terminal differentiation into plasma cells. Distinct in vivo and in vitro strategies based on lycopene supplementation were used direct in Balb/c mice or in culture systems with cells derived of these mice. In the bone marrow, lycopene expanded B220+IgM- progenitor B cells and B220+IgM+ immature B lymphocytes. In the spleen, lycopene induced terminal CD138+ plasma cell generation. In the blood, we found prominent IgA and low IgM levels after lycopene administration. Interestingly, the pattern of peritoneal IgM+ and IgA+ B cells indicated a significant IgM-to-IgA class switching after lycopene injection. These data indicated that lycopene induces B cell differentiation into IgA-producing plasma cells. Thus, a new cellular function has been attributed to lycopene for B lymphocyte biology and possibly associated with humoral responses and mucosal immunity. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000700602 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652022000700602 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202220210002 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.94 suppl.3 2022 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
_version_ |
1754302872796790784 |