Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease

Detalhes bibliográficos
Autor(a) principal: DEFELICE,FERNANDA G.
Data de Publicação: 2002
Outros Autores: FERREIRA,SÉRGIO T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006
Resumo: The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity.
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spelling Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's diseaseAlzheimer's diseaseAbeta peptideaggregationneurotoxicityphysiopathological modulatorsThe biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity.Academia Brasileira de Ciências2002-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006Anais da Academia Brasileira de Ciências v.74 n.2 2002reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652002000200006info:eu-repo/semantics/openAccessDEFELICE,FERNANDA G.FERREIRA,SÉRGIO T.eng2002-07-17T00:00:00Zoai:scielo:S0001-37652002000200006Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2002-07-17T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
title Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
spellingShingle Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
DEFELICE,FERNANDA G.
Alzheimer's disease
Abeta peptide
aggregation
neurotoxicity
physiopathological modulators
title_short Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
title_full Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
title_fullStr Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
title_full_unstemmed Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
title_sort Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease
author DEFELICE,FERNANDA G.
author_facet DEFELICE,FERNANDA G.
FERREIRA,SÉRGIO T.
author_role author
author2 FERREIRA,SÉRGIO T.
author2_role author
dc.contributor.author.fl_str_mv DEFELICE,FERNANDA G.
FERREIRA,SÉRGIO T.
dc.subject.por.fl_str_mv Alzheimer's disease
Abeta peptide
aggregation
neurotoxicity
physiopathological modulators
topic Alzheimer's disease
Abeta peptide
aggregation
neurotoxicity
physiopathological modulators
description The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity.
publishDate 2002
dc.date.none.fl_str_mv 2002-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652002000200006
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.74 n.2 2002
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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