Immune System Dysfunction in the Elderly

Detalhes bibliográficos
Autor(a) principal: FUENTES,EDUARDO
Data de Publicação: 2017
Outros Autores: FUENTES,MANUEL, ALARCÓN,MARCELO, PALOMO,IVÁN
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285
Resumo: ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.
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spelling Immune System Dysfunction in the Elderlyagingimmunosenescenceadaptive immunityinnate immunityinflammation.ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.Academia Brasileira de Ciências2017-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285Anais da Academia Brasileira de Ciências v.89 n.1 2017reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201720160487info:eu-repo/semantics/openAccessFUENTES,EDUARDOFUENTES,MANUELALARCÓN,MARCELOPALOMO,IVÁNeng2017-04-11T00:00:00Zoai:scielo:S0001-37652017000100285Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2017-04-11T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Immune System Dysfunction in the Elderly
title Immune System Dysfunction in the Elderly
spellingShingle Immune System Dysfunction in the Elderly
FUENTES,EDUARDO
aging
immunosenescence
adaptive immunity
innate immunity
inflammation.
title_short Immune System Dysfunction in the Elderly
title_full Immune System Dysfunction in the Elderly
title_fullStr Immune System Dysfunction in the Elderly
title_full_unstemmed Immune System Dysfunction in the Elderly
title_sort Immune System Dysfunction in the Elderly
author FUENTES,EDUARDO
author_facet FUENTES,EDUARDO
FUENTES,MANUEL
ALARCÓN,MARCELO
PALOMO,IVÁN
author_role author
author2 FUENTES,MANUEL
ALARCÓN,MARCELO
PALOMO,IVÁN
author2_role author
author
author
dc.contributor.author.fl_str_mv FUENTES,EDUARDO
FUENTES,MANUEL
ALARCÓN,MARCELO
PALOMO,IVÁN
dc.subject.por.fl_str_mv aging
immunosenescence
adaptive immunity
innate immunity
inflammation.
topic aging
immunosenescence
adaptive immunity
innate immunity
inflammation.
description ABSTRACT Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic low-level inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000100285
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201720160487
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.89 n.1 2017
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
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institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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