Effects of electroacupuncture on stress and anxiety-related responses in rats

Detalhes bibliográficos
Autor(a) principal: BASSETTO,RICARDO M.
Data de Publicação: 2017
Outros Autores: WSCIEKLICA,TATIANA, POUZA,KATHLEIN C.P., ORTOLANI,DANIELA, VIANA,MILENA B., CESPEDES,ISABEL C., SPADARI,REGINA C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301003
Resumo: ABSTRACT The aim of this work was to investigate if eletroacupuncture at PC6 would modulate the stress-induced anxiety-like behavior and the level of activation of several brain areas. Rats were distributed in groups: control; submitted to immobilization; submitted to immobilization and eletroacupuncture at PC6 or at the tail. Immobilization increased grooming and decreased stretched attend postures and the time spent in the open arms of the ele-vated plus-maze. Eletroacupuncture at PC6 or tail canceled the effect of immobilization on grooming and attenuated the stretched attend posture. Immobilization increased Fos-immunoreactivity in the prefrontal cortex, medial and central amygdala, paraventricular and dorsomedial nuclei of the hypothalamus, lateral hypothalamus, dentate gyrus, CA1, CA2 and CA3 hippocampal areas. The activation of paraventricular, dorsomedial nuclei and prefrontal cortex by immobilization was canceled by electroacupuncture at PC6 and attenuated by electroacupuncture in the tail. The activation of the other areas was canceled by electroacupuncture in PC6 or the tail. It is concluded that immobilization induced anxiety-like behavior that was moderately attenuated by eletroacupuncture with difference between the stimulation in PC6 or the rat tail. Eletroacupuncture showed specificity concerning to the attenuation of the effects of immobilization in the CNS areas related to the stress response, anxiety and cardiovascular system.
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spelling Effects of electroacupuncture on stress and anxiety-related responses in ratsstresselectroacupunctureanxietyelevated plus-mazeFos-immunoreactivityABSTRACT The aim of this work was to investigate if eletroacupuncture at PC6 would modulate the stress-induced anxiety-like behavior and the level of activation of several brain areas. Rats were distributed in groups: control; submitted to immobilization; submitted to immobilization and eletroacupuncture at PC6 or at the tail. Immobilization increased grooming and decreased stretched attend postures and the time spent in the open arms of the ele-vated plus-maze. Eletroacupuncture at PC6 or tail canceled the effect of immobilization on grooming and attenuated the stretched attend posture. Immobilization increased Fos-immunoreactivity in the prefrontal cortex, medial and central amygdala, paraventricular and dorsomedial nuclei of the hypothalamus, lateral hypothalamus, dentate gyrus, CA1, CA2 and CA3 hippocampal areas. The activation of paraventricular, dorsomedial nuclei and prefrontal cortex by immobilization was canceled by electroacupuncture at PC6 and attenuated by electroacupuncture in the tail. The activation of the other areas was canceled by electroacupuncture in PC6 or the tail. It is concluded that immobilization induced anxiety-like behavior that was moderately attenuated by eletroacupuncture with difference between the stimulation in PC6 or the rat tail. Eletroacupuncture showed specificity concerning to the attenuation of the effects of immobilization in the CNS areas related to the stress response, anxiety and cardiovascular system.Academia Brasileira de Ciências2017-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301003Anais da Academia Brasileira de Ciências v.89 n.2 2017reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201720160531info:eu-repo/semantics/openAccessBASSETTO,RICARDO M.WSCIEKLICA,TATIANAPOUZA,KATHLEIN C.P.ORTOLANI,DANIELAVIANA,MILENA B.CESPEDES,ISABEL C.SPADARI,REGINA C.eng2017-06-07T00:00:00Zoai:scielo:S0001-37652017000301003Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2017-06-07T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Effects of electroacupuncture on stress and anxiety-related responses in rats
title Effects of electroacupuncture on stress and anxiety-related responses in rats
spellingShingle Effects of electroacupuncture on stress and anxiety-related responses in rats
BASSETTO,RICARDO M.
stress
electroacupuncture
anxiety
elevated plus-maze
Fos-immunoreactivity
title_short Effects of electroacupuncture on stress and anxiety-related responses in rats
title_full Effects of electroacupuncture on stress and anxiety-related responses in rats
title_fullStr Effects of electroacupuncture on stress and anxiety-related responses in rats
title_full_unstemmed Effects of electroacupuncture on stress and anxiety-related responses in rats
title_sort Effects of electroacupuncture on stress and anxiety-related responses in rats
author BASSETTO,RICARDO M.
author_facet BASSETTO,RICARDO M.
WSCIEKLICA,TATIANA
POUZA,KATHLEIN C.P.
ORTOLANI,DANIELA
VIANA,MILENA B.
CESPEDES,ISABEL C.
SPADARI,REGINA C.
author_role author
author2 WSCIEKLICA,TATIANA
POUZA,KATHLEIN C.P.
ORTOLANI,DANIELA
VIANA,MILENA B.
CESPEDES,ISABEL C.
SPADARI,REGINA C.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv BASSETTO,RICARDO M.
WSCIEKLICA,TATIANA
POUZA,KATHLEIN C.P.
ORTOLANI,DANIELA
VIANA,MILENA B.
CESPEDES,ISABEL C.
SPADARI,REGINA C.
dc.subject.por.fl_str_mv stress
electroacupuncture
anxiety
elevated plus-maze
Fos-immunoreactivity
topic stress
electroacupuncture
anxiety
elevated plus-maze
Fos-immunoreactivity
description ABSTRACT The aim of this work was to investigate if eletroacupuncture at PC6 would modulate the stress-induced anxiety-like behavior and the level of activation of several brain areas. Rats were distributed in groups: control; submitted to immobilization; submitted to immobilization and eletroacupuncture at PC6 or at the tail. Immobilization increased grooming and decreased stretched attend postures and the time spent in the open arms of the ele-vated plus-maze. Eletroacupuncture at PC6 or tail canceled the effect of immobilization on grooming and attenuated the stretched attend posture. Immobilization increased Fos-immunoreactivity in the prefrontal cortex, medial and central amygdala, paraventricular and dorsomedial nuclei of the hypothalamus, lateral hypothalamus, dentate gyrus, CA1, CA2 and CA3 hippocampal areas. The activation of paraventricular, dorsomedial nuclei and prefrontal cortex by immobilization was canceled by electroacupuncture at PC6 and attenuated by electroacupuncture in the tail. The activation of the other areas was canceled by electroacupuncture in PC6 or the tail. It is concluded that immobilization induced anxiety-like behavior that was moderately attenuated by eletroacupuncture with difference between the stimulation in PC6 or the rat tail. Eletroacupuncture showed specificity concerning to the attenuation of the effects of immobilization in the CNS areas related to the stress response, anxiety and cardiovascular system.
publishDate 2017
dc.date.none.fl_str_mv 2017-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301003
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000301003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201720160531
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.89 n.2 2017
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
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institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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