Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity

Detalhes bibliográficos
Autor(a) principal: VICTOR,MAURICIO M.
Data de Publicação: 2017
Outros Autores: DAVID,JORGE M., SAKUKUMA,MARIA C.K., COSTA-LOTUFO,LETÍCIA V., MOURA,ANDREA F., ARAÚJO,ANA J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401369
Resumo: ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
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spelling Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activityantitumor activitychemical modificationderivative synthesisnatural products estersABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.Academia Brasileira de Ciências2017-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401369Anais da Academia Brasileira de Ciências v.89 n.3 2017reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765201720160780info:eu-repo/semantics/openAccessVICTOR,MAURICIO M.DAVID,JORGE M.SAKUKUMA,MARIA C.K.COSTA-LOTUFO,LETÍCIA V.MOURA,ANDREA F.ARAÚJO,ANA J.eng2019-11-29T00:00:00Zoai:scielo:S0001-37652017000401369Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2019-11-29T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
title Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
spellingShingle Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
VICTOR,MAURICIO M.
antitumor activity
chemical modification
derivative synthesis
natural products esters
title_short Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
title_full Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
title_fullStr Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
title_full_unstemmed Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
title_sort Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity
author VICTOR,MAURICIO M.
author_facet VICTOR,MAURICIO M.
DAVID,JORGE M.
SAKUKUMA,MARIA C.K.
COSTA-LOTUFO,LETÍCIA V.
MOURA,ANDREA F.
ARAÚJO,ANA J.
author_role author
author2 DAVID,JORGE M.
SAKUKUMA,MARIA C.K.
COSTA-LOTUFO,LETÍCIA V.
MOURA,ANDREA F.
ARAÚJO,ANA J.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv VICTOR,MAURICIO M.
DAVID,JORGE M.
SAKUKUMA,MARIA C.K.
COSTA-LOTUFO,LETÍCIA V.
MOURA,ANDREA F.
ARAÚJO,ANA J.
dc.subject.por.fl_str_mv antitumor activity
chemical modification
derivative synthesis
natural products esters
topic antitumor activity
chemical modification
derivative synthesis
natural products esters
description ABSTRACT Natural steroids and triterpenes such as b-sitosterol, stigmasterol, lupeol, ursolic and betulinic acids were transformed into its hexanoic and oleic esters, to evaluate the influence of chemical modification towards the cytotoxic activities against tumor cells. The derivatives were evaluated against five tumor cell lines [OVCAR-8 (ovarian carcinoma); SF-295 (glioblastoma); HCT-116 (colon adenocarcinoma); HL-60 (leukemia); and PC-3 (prostate carcinoma)] and the results showed only betulinic acid hexyl ester exhibits cytotoxic potential activity.
publishDate 2017
dc.date.none.fl_str_mv 2017-09-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401369
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000401369
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765201720160780
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.89 n.3 2017
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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