A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity

Detalhes bibliográficos
Autor(a) principal: Boeck,Paula
Data de Publicação: 2005
Outros Autores: Sá,Marcus M., Souza,Bruno S. de, Cercená,Rodrigo, Escalante,Andréa M., Zachino,Susana A., Cechinel Filho,Valdir, Yunes,Rosendo A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Journal of the Brazilian Chemical Society (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000800009
Resumo: Representative esters derived from kaurenoic acid were prepared in order to evaluate their antifungal properties. Alkyl and substituted benzyl esters were obtained in good yield under mild conditions by esterification of kaurenoic acid with the corresponding alkyl halide in KOH-acetone. All synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophytes. Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes.
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spelling A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activitykaurenoic acidestersWedelia paludosaantifungal activityRepresentative esters derived from kaurenoic acid were prepared in order to evaluate their antifungal properties. Alkyl and substituted benzyl esters were obtained in good yield under mild conditions by esterification of kaurenoic acid with the corresponding alkyl halide in KOH-acetone. All synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophytes. Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes.Sociedade Brasileira de Química2005-11-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000800009Journal of the Brazilian Chemical Society v.16 n.6b 2005reponame:Journal of the Brazilian Chemical Society (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0103-50532005000800009info:eu-repo/semantics/openAccessBoeck,PaulaSá,Marcus M.Souza,Bruno S. deCercená,RodrigoEscalante,Andréa M.Zachino,Susana A.Cechinel Filho,ValdirYunes,Rosendo A.eng2006-01-20T00:00:00Zoai:scielo:S0103-50532005000800009Revistahttp://jbcs.sbq.org.brONGhttps://old.scielo.br/oai/scielo-oai.php||office@jbcs.sbq.org.br1678-47900103-5053opendoar:2006-01-20T00:00Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
title A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
spellingShingle A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
Boeck,Paula
kaurenoic acid
esters
Wedelia paludosa
antifungal activity
title_short A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
title_full A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
title_fullStr A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
title_full_unstemmed A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
title_sort A simple synthesis of kaurenoic esters and other derivatives and evaluation of their antifungal activity
author Boeck,Paula
author_facet Boeck,Paula
Sá,Marcus M.
Souza,Bruno S. de
Cercená,Rodrigo
Escalante,Andréa M.
Zachino,Susana A.
Cechinel Filho,Valdir
Yunes,Rosendo A.
author_role author
author2 Sá,Marcus M.
Souza,Bruno S. de
Cercená,Rodrigo
Escalante,Andréa M.
Zachino,Susana A.
Cechinel Filho,Valdir
Yunes,Rosendo A.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Boeck,Paula
Sá,Marcus M.
Souza,Bruno S. de
Cercená,Rodrigo
Escalante,Andréa M.
Zachino,Susana A.
Cechinel Filho,Valdir
Yunes,Rosendo A.
dc.subject.por.fl_str_mv kaurenoic acid
esters
Wedelia paludosa
antifungal activity
topic kaurenoic acid
esters
Wedelia paludosa
antifungal activity
description Representative esters derived from kaurenoic acid were prepared in order to evaluate their antifungal properties. Alkyl and substituted benzyl esters were obtained in good yield under mild conditions by esterification of kaurenoic acid with the corresponding alkyl halide in KOH-acetone. All synthesized compounds were tested for antifungal properties against pathogenic yeasts, hialohyphomycetes and dermatophytes. Kaurenoic acid and derivatives containing a free carboxyl group were moderately active against dermatophytes.
publishDate 2005
dc.date.none.fl_str_mv 2005-11-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000800009
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532005000800009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0103-50532005000800009
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Journal of the Brazilian Chemical Society v.16 n.6b 2005
reponame:Journal of the Brazilian Chemical Society (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Journal of the Brazilian Chemical Society (Online)
collection Journal of the Brazilian Chemical Society (Online)
repository.name.fl_str_mv Journal of the Brazilian Chemical Society (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv ||office@jbcs.sbq.org.br
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