Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Anais da Academia Brasileira de Ciências (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000400728 |
Resumo: | Abstract Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work. |
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Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureusStaphylococcus aureusantibiotic resistancebacteriocinsbiotechnology use of bacteriocinsAbstract Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work.Academia Brasileira de Ciências2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000400728Anais da Academia Brasileira de Ciências v.92 suppl.2 2020reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202020201216info:eu-repo/semantics/openAccessLEITE,ELMA L.OLIVEIRA JR,ALBERTO F. DECARMO,FILLIPE L.R. DOBERKOVA,NADIABARH,DEBMALYAGHOSH,PREETAMAZEVEDO,VASCOeng2020-10-15T00:00:00Zoai:scielo:S0001-37652020000400728Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2020-10-15T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false |
dc.title.none.fl_str_mv |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
title |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
spellingShingle |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus LEITE,ELMA L. Staphylococcus aureus antibiotic resistance bacteriocins biotechnology use of bacteriocins |
title_short |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
title_full |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
title_fullStr |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
title_full_unstemmed |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
title_sort |
Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus |
author |
LEITE,ELMA L. |
author_facet |
LEITE,ELMA L. OLIVEIRA JR,ALBERTO F. DE CARMO,FILLIPE L.R. DO BERKOVA,NADIA BARH,DEBMALYA GHOSH,PREETAM AZEVEDO,VASCO |
author_role |
author |
author2 |
OLIVEIRA JR,ALBERTO F. DE CARMO,FILLIPE L.R. DO BERKOVA,NADIA BARH,DEBMALYA GHOSH,PREETAM AZEVEDO,VASCO |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
LEITE,ELMA L. OLIVEIRA JR,ALBERTO F. DE CARMO,FILLIPE L.R. DO BERKOVA,NADIA BARH,DEBMALYA GHOSH,PREETAM AZEVEDO,VASCO |
dc.subject.por.fl_str_mv |
Staphylococcus aureus antibiotic resistance bacteriocins biotechnology use of bacteriocins |
topic |
Staphylococcus aureus antibiotic resistance bacteriocins biotechnology use of bacteriocins |
description |
Abstract Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000400728 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000400728 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/0001-3765202020201216 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
publisher.none.fl_str_mv |
Academia Brasileira de Ciências |
dc.source.none.fl_str_mv |
Anais da Academia Brasileira de Ciências v.92 suppl.2 2020 reponame:Anais da Academia Brasileira de Ciências (Online) instname:Academia Brasileira de Ciências (ABC) instacron:ABC |
instname_str |
Academia Brasileira de Ciências (ABC) |
instacron_str |
ABC |
institution |
ABC |
reponame_str |
Anais da Academia Brasileira de Ciências (Online) |
collection |
Anais da Academia Brasileira de Ciências (Online) |
repository.name.fl_str_mv |
Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC) |
repository.mail.fl_str_mv |
||aabc@abc.org.br |
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1754302868981022720 |