Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus

Detalhes bibliográficos
Autor(a) principal: LEITE,ELMA L.
Data de Publicação: 2020
Outros Autores: OLIVEIRA JR,ALBERTO F. DE, CARMO,FILLIPE L.R. DO, BERKOVA,NADIA, BARH,DEBMALYA, GHOSH,PREETAM, AZEVEDO,VASCO
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000400728
Resumo: Abstract Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work.
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spelling Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureusStaphylococcus aureusantibiotic resistancebacteriocinsbiotechnology use of bacteriocinsAbstract Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work.Academia Brasileira de Ciências2020-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000400728Anais da Academia Brasileira de Ciências v.92 suppl.2 2020reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202020201216info:eu-repo/semantics/openAccessLEITE,ELMA L.OLIVEIRA JR,ALBERTO F. DECARMO,FILLIPE L.R. DOBERKOVA,NADIABARH,DEBMALYAGHOSH,PREETAMAZEVEDO,VASCOeng2020-10-15T00:00:00Zoai:scielo:S0001-37652020000400728Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2020-10-15T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
title Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
spellingShingle Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
LEITE,ELMA L.
Staphylococcus aureus
antibiotic resistance
bacteriocins
biotechnology use of bacteriocins
title_short Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
title_full Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
title_fullStr Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
title_full_unstemmed Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
title_sort Bacteriocins as an alternative in the treatment of infections by Staphylococcus aureus
author LEITE,ELMA L.
author_facet LEITE,ELMA L.
OLIVEIRA JR,ALBERTO F. DE
CARMO,FILLIPE L.R. DO
BERKOVA,NADIA
BARH,DEBMALYA
GHOSH,PREETAM
AZEVEDO,VASCO
author_role author
author2 OLIVEIRA JR,ALBERTO F. DE
CARMO,FILLIPE L.R. DO
BERKOVA,NADIA
BARH,DEBMALYA
GHOSH,PREETAM
AZEVEDO,VASCO
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv LEITE,ELMA L.
OLIVEIRA JR,ALBERTO F. DE
CARMO,FILLIPE L.R. DO
BERKOVA,NADIA
BARH,DEBMALYA
GHOSH,PREETAM
AZEVEDO,VASCO
dc.subject.por.fl_str_mv Staphylococcus aureus
antibiotic resistance
bacteriocins
biotechnology use of bacteriocins
topic Staphylococcus aureus
antibiotic resistance
bacteriocins
biotechnology use of bacteriocins
description Abstract Staphylococcus aureus (S. aureus) is a highly versatile Gram-positive bacterium that is carried asymptomatically by up to 30% of healthy people, while being a major cause of healthcare-associated infections, making it a worldwide problem in clinical medicine. The adaptive evolution of S. aureus strains is demonstrated by its remarkable capacity to promptly develop high resistance to multiple antibiotics, thus limiting treatment choice. Nowadays, there is a continuous demand for an alternative to the use of antibiotics for S. aureus infections and a strategy to control the spread or to kill phylogenetically related strains. In this scenario, bacteriocins fit as with a promising and interesting alternative. These molecules are produced by a range of bacteria, defined as ribosomally synthesized peptides with bacteriostatic or bactericidal activity against a wide range of pathogens. This work reviews ascertained the main antibiotic-resistance mechanisms of S. aureus strains and the current, informative content concerning the applicability of the use of bacteriocins overlapping the use of conventional antibiotics in the context of S. aureus infections. Besides, we highlight the possible application of these biomolecules on an industrial scale in future work.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01
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dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202020201216
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dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.92 suppl.2 2020
reponame:Anais da Academia Brasileira de Ciências (Online)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
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