The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes

Detalhes bibliográficos
Autor(a) principal: MIATMOKO,ANDANG
Data de Publicação: 2021
Outros Autores: HARIAWAN,BERLIAN S., CAHYANI,DEVY M., SARI,RETNO, DINARYANTI,ARISTIKA, HENDRIANTO,ERYK
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500806
Resumo: Abstract This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher cytotoxicity in HeLa cells than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, chitosan layers improved the cellular uptake, which clathrin-mediated endocytosis may determine the cellular transport of UA niosomes. In conclusion, the addition of chitosan improved cellular uptake and cytotoxicity of UA niosomes in the HeLa cells.
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spelling The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomesChitosanniosomesursolic acidcytotoxicitycell uptakecancerAbstract This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher cytotoxicity in HeLa cells than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, chitosan layers improved the cellular uptake, which clathrin-mediated endocytosis may determine the cellular transport of UA niosomes. In conclusion, the addition of chitosan improved cellular uptake and cytotoxicity of UA niosomes in the HeLa cells.Academia Brasileira de Ciências2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500806Anais da Academia Brasileira de Ciências v.93 n.3 2021reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/0001-3765202120201850info:eu-repo/semantics/openAccessMIATMOKO,ANDANGHARIAWAN,BERLIAN S.CAHYANI,DEVY M.SARI,RETNODINARYANTI,ARISTIKAHENDRIANTO,ERYKeng2021-07-15T00:00:00Zoai:scielo:S0001-37652021000500806Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2021-07-15T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
title The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
spellingShingle The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
MIATMOKO,ANDANG
Chitosan
niosomes
ursolic acid
cytotoxicity
cell uptake
cancer
title_short The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
title_full The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
title_fullStr The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
title_full_unstemmed The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
title_sort The effect of chitosan addition on cellular uptake and cytotoxicity of ursolic acid niosomes
author MIATMOKO,ANDANG
author_facet MIATMOKO,ANDANG
HARIAWAN,BERLIAN S.
CAHYANI,DEVY M.
SARI,RETNO
DINARYANTI,ARISTIKA
HENDRIANTO,ERYK
author_role author
author2 HARIAWAN,BERLIAN S.
CAHYANI,DEVY M.
SARI,RETNO
DINARYANTI,ARISTIKA
HENDRIANTO,ERYK
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv MIATMOKO,ANDANG
HARIAWAN,BERLIAN S.
CAHYANI,DEVY M.
SARI,RETNO
DINARYANTI,ARISTIKA
HENDRIANTO,ERYK
dc.subject.por.fl_str_mv Chitosan
niosomes
ursolic acid
cytotoxicity
cell uptake
cancer
topic Chitosan
niosomes
ursolic acid
cytotoxicity
cell uptake
cancer
description Abstract This study evaluated the cellular uptake and cytotoxicity of low permeable Ursolic acid (UA) on cancer cells using niosomes composed of span 60 and cholesterol. The results showed that the addition of chitosan increased particle sizes and ζ-potentials. The UA niosomes with chitosan layers had higher cytotoxicity in HeLa cells than without chitosan, however, there was no improvement observed for Huh7it cells. Moreover, chitosan layers improved the cellular uptake, which clathrin-mediated endocytosis may determine the cellular transport of UA niosomes. In conclusion, the addition of chitosan improved cellular uptake and cytotoxicity of UA niosomes in the HeLa cells.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500806
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652021000500806
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0001-3765202120201850
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.93 n.3 2021
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
instacron_str ABC
institution ABC
reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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