Insulin-like Growth Factor 1 gene polymorphism and breast cancer risk

• Autor(a) principal: COSTA-SILVA,DANYLO R.
• Data de Publicação: 2016
• Outros Autores: BARROS-OLIVEIRA,MARIA DA CONCEIÇÃO, BORGES,RAFAEL S., TAVARES,CLÉCITON B., BORGES,UMBELINA S., ALVES-RIBEIRO,FRANCISCO A., SILVA,VLADIMIR C., SILVA,BENEDITO B. DA
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Anais da Academia Brasileira de Ciências (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602349
• topic: Breast cancer; risk factors; IGF-1; IGF-1 gene polymorphism

ABSTRACT Insulin-like Growth Factor-1 (IGF-1) gene polymorphism has been associated with an increased risk for breast cancer. IGF-1 is a key regulator of proliferation, cell differentiation and apoptosis. It has important mitogenic and anti-apoptotic activities in normal cells and in breast cancer cells, acting synergistically with estrogen to increase neoplastic cell proliferation. This review aims to present the recent finds of IGF-1 gene polymorphism and its relationship with the risk of breast cancer through following the polymorphic dinucleotide repeat cytosine-adenine (CA) and single nucleotide polymorphisms (SNPs) by searching in the PubMed database publications focused studies published from 2010 to 2015 related to IGF-1 gene polymorphism and breast cancer risk. A growing number of studies support an association between IGF-1 gene polymorphism and breast cancer risk with conflicting results, nevertheless elucidation of the patterns of IGF-1 gene expression may permit characterization of women at high-risk for breast cancer, as well as the development of strategies for early diagnosis and efficient treatment against the disease.