Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans

Detalhes bibliográficos
Autor(a) principal: Busso,Cleverson
Data de Publicação: 2004
Outros Autores: Castro-Prado,Marialba A. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais da Academia Brasileira de Ciências (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100005
Resumo: Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel's clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were determined for the evaluation of the recombinagenic effect of cremophor EL. It has been shown that cremophor EL induces increase in mitotic crossing-over events at nontoxic concentrations (0.05 and 0.075% v/v).
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spelling Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulansAspergillus nidulansmitotic recombinationcremophor ELHomozygotization Indexantineoplasm agentsCremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel's clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were determined for the evaluation of the recombinagenic effect of cremophor EL. It has been shown that cremophor EL induces increase in mitotic crossing-over events at nontoxic concentrations (0.05 and 0.075% v/v).Academia Brasileira de Ciências2004-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100005Anais da Academia Brasileira de Ciências v.76 n.1 2004reponame:Anais da Academia Brasileira de Ciências (Online)instname:Academia Brasileira de Ciências (ABC)instacron:ABC10.1590/S0001-37652004000100005info:eu-repo/semantics/openAccessBusso,CleversonCastro-Prado,Marialba A. A.eng2004-02-18T00:00:00Zoai:scielo:S0001-37652004000100005Revistahttp://www.scielo.br/aabchttps://old.scielo.br/oai/scielo-oai.php||aabc@abc.org.br1678-26900001-3765opendoar:2004-02-18T00:00Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)false
dc.title.none.fl_str_mv Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
title Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
spellingShingle Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
Busso,Cleverson
Aspergillus nidulans
mitotic recombination
cremophor EL
Homozygotization Index
antineoplasm agents
title_short Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
title_full Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
title_fullStr Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
title_full_unstemmed Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
title_sort Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
author Busso,Cleverson
author_facet Busso,Cleverson
Castro-Prado,Marialba A. A.
author_role author
author2 Castro-Prado,Marialba A. A.
author2_role author
dc.contributor.author.fl_str_mv Busso,Cleverson
Castro-Prado,Marialba A. A.
dc.subject.por.fl_str_mv Aspergillus nidulans
mitotic recombination
cremophor EL
Homozygotization Index
antineoplasm agents
topic Aspergillus nidulans
mitotic recombination
cremophor EL
Homozygotization Index
antineoplasm agents
description Cremophor EL is a solubilizer and emulsifier agent used in the pharmaceutical and foodstuff industries. The solvent is the principal constituent of paclitaxel's clinical formulation vehicle. Since mitotic recombination plays a crucial role in multistep carcinogenesis, the study of the recombinagenic potential of chemical compounds is of the utmost importance. In our research genotoxicity of cremophor EL has been studied by using an uvsH//uvsH diploid strain of Aspergillus nidulans. Since it spends a great part of its cell cycle in the G2period, this fungus is a special screening system for the study of mitotic recombination induced by chemical substances. Homozygotization Indexes (HI) for paba and bi markers from heterozygous B211//A837 diploid strain were determined for the evaluation of the recombinagenic effect of cremophor EL. It has been shown that cremophor EL induces increase in mitotic crossing-over events at nontoxic concentrations (0.05 and 0.075% v/v).
publishDate 2004
dc.date.none.fl_str_mv 2004-03-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100005
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0001-37652004000100005
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Academia Brasileira de Ciências
publisher.none.fl_str_mv Academia Brasileira de Ciências
dc.source.none.fl_str_mv Anais da Academia Brasileira de Ciências v.76 n.1 2004
reponame:Anais da Academia Brasileira de Ciências (Online)
instname:Academia Brasileira de Ciências (ABC)
instacron:ABC
instname_str Academia Brasileira de Ciências (ABC)
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reponame_str Anais da Academia Brasileira de Ciências (Online)
collection Anais da Academia Brasileira de Ciências (Online)
repository.name.fl_str_mv Anais da Academia Brasileira de Ciências (Online) - Academia Brasileira de Ciências (ABC)
repository.mail.fl_str_mv ||aabc@abc.org.br
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