Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment

Detalhes bibliográficos
Autor(a) principal: Cordeiro,J.P.
Data de Publicação: 2021
Outros Autores: Silva,V.L. da, Campos,D.H., Cicogna,A.C., Leopoldo,A.S., Lima-Leopoldo,A.P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000603
Resumo: Mechanisms involved in cardiac function and calcium (Ca2+) handling in obese-resistant (OR) rats are still poorly determined. We tested the hypothesis that unsaturated high-fat diet (HFD) promotes myocardial dysfunction in OR rats, which it is related to Ca2+ handling. In addition, we questioned whether exercise training (ET) becomes a therapeutic strategy. Male Wistar rats (n=80) were randomized to standard or HFD diets for 20 weeks. The rats were redistributed for the absence or presence of ET and OR: control (C; n=12), control + ET (CET; n=14), obese-resistant (OR; n=9), and obese-resistant + ET (ORET; n=10). Trained rats were subjected to aerobic training protocol with progressive intensity (55-70% of the maximum running speed) and duration (15 to 60 min/day) for 12 weeks. Nutritional, metabolic, and cardiovascular parameters were determined. Cardiac function and Ca2+ handling tests were performed in isolated left ventricle (LV) papillary muscle. OR rats showed cardiac atrophy with reduced collagen levels, but there was myocardial dysfunction. ET was efficient in improving most parameters of body composition. However, the mechanical properties and Ca2+ handling from isolated papillary muscle were similar among groups. Aerobic ET does not promote morphological and cardiac functional adaptation under the condition of OR.
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spelling Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairmentHigh-fat dietObesityResistance to obesityExercise trainingMyocardial functionCalcium handlingMechanisms involved in cardiac function and calcium (Ca2+) handling in obese-resistant (OR) rats are still poorly determined. We tested the hypothesis that unsaturated high-fat diet (HFD) promotes myocardial dysfunction in OR rats, which it is related to Ca2+ handling. In addition, we questioned whether exercise training (ET) becomes a therapeutic strategy. Male Wistar rats (n=80) were randomized to standard or HFD diets for 20 weeks. The rats were redistributed for the absence or presence of ET and OR: control (C; n=12), control + ET (CET; n=14), obese-resistant (OR; n=9), and obese-resistant + ET (ORET; n=10). Trained rats were subjected to aerobic training protocol with progressive intensity (55-70% of the maximum running speed) and duration (15 to 60 min/day) for 12 weeks. Nutritional, metabolic, and cardiovascular parameters were determined. Cardiac function and Ca2+ handling tests were performed in isolated left ventricle (LV) papillary muscle. OR rats showed cardiac atrophy with reduced collagen levels, but there was myocardial dysfunction. ET was efficient in improving most parameters of body composition. However, the mechanical properties and Ca2+ handling from isolated papillary muscle were similar among groups. Aerobic ET does not promote morphological and cardiac functional adaptation under the condition of OR.Associação Brasileira de Divulgação Científica2021-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000603Brazilian Journal of Medical and Biological Research v.54 n.10 2021reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/1414-431x2020e10669info:eu-repo/semantics/openAccessCordeiro,J.P.Silva,V.L. daCampos,D.H.Cicogna,A.C.Leopoldo,A.S.Lima-Leopoldo,A.P.eng2021-07-13T00:00:00Zoai:scielo:S0100-879X2021001000603Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2021-07-13T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
title Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
spellingShingle Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
Cordeiro,J.P.
High-fat diet
Obesity
Resistance to obesity
Exercise training
Myocardial function
Calcium handling
title_short Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
title_full Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
title_fullStr Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
title_full_unstemmed Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
title_sort Isolated obesity resistance condition or associated with aerobic exercise training does not promote cardiac impairment
author Cordeiro,J.P.
author_facet Cordeiro,J.P.
Silva,V.L. da
Campos,D.H.
Cicogna,A.C.
Leopoldo,A.S.
Lima-Leopoldo,A.P.
author_role author
author2 Silva,V.L. da
Campos,D.H.
Cicogna,A.C.
Leopoldo,A.S.
Lima-Leopoldo,A.P.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cordeiro,J.P.
Silva,V.L. da
Campos,D.H.
Cicogna,A.C.
Leopoldo,A.S.
Lima-Leopoldo,A.P.
dc.subject.por.fl_str_mv High-fat diet
Obesity
Resistance to obesity
Exercise training
Myocardial function
Calcium handling
topic High-fat diet
Obesity
Resistance to obesity
Exercise training
Myocardial function
Calcium handling
description Mechanisms involved in cardiac function and calcium (Ca2+) handling in obese-resistant (OR) rats are still poorly determined. We tested the hypothesis that unsaturated high-fat diet (HFD) promotes myocardial dysfunction in OR rats, which it is related to Ca2+ handling. In addition, we questioned whether exercise training (ET) becomes a therapeutic strategy. Male Wistar rats (n=80) were randomized to standard or HFD diets for 20 weeks. The rats were redistributed for the absence or presence of ET and OR: control (C; n=12), control + ET (CET; n=14), obese-resistant (OR; n=9), and obese-resistant + ET (ORET; n=10). Trained rats were subjected to aerobic training protocol with progressive intensity (55-70% of the maximum running speed) and duration (15 to 60 min/day) for 12 weeks. Nutritional, metabolic, and cardiovascular parameters were determined. Cardiac function and Ca2+ handling tests were performed in isolated left ventricle (LV) papillary muscle. OR rats showed cardiac atrophy with reduced collagen levels, but there was myocardial dysfunction. ET was efficient in improving most parameters of body composition. However, the mechanical properties and Ca2+ handling from isolated papillary muscle were similar among groups. Aerobic ET does not promote morphological and cardiac functional adaptation under the condition of OR.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000603
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2021001000603
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/1414-431x2020e10669
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.54 n.10 2021
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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