Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5935/abc.20150134 http://hdl.handle.net/11449/165058 |
Resumo: | Background: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Methods: Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. Results: The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Conclusion: Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling. |
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Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ HandlingObesity-ResistanceHigh-Fat DietCardiac FunctionCa2+ HandlingRatsBackground: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Methods: Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. Results: The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Conclusion: Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling.FAPES/ESUniv Fed Espirito Santo, Dept Desportos, Ctr Educ Fis & Desportos, Vitoria, ES, BrazilUniv Estadual Paulista, Fac Med, Dept Clin Med, Sao Paulo, BrazilUniv Estadual Paulista, Fac Med, Dept Clin Med, Sao Paulo, BrazilArquivos Brasileiros CardiologiaUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Santos de Sa, Felipe Goncalves dosLima-Leopoldo, Ana PaulaJacobsen, Bruno BarcellosTogneri Ferron, Artur JunioEstevam, Wagner MullerSalome Campos, Dijon Henrique [UNESP]Castardeli, EdsonHolanda da Cunha, Marcia ReginaCicogna, Antonio Carlos [UNESP]Leopoldo, Andre Soares2018-11-27T08:30:22Z2018-11-27T08:30:22Z2015-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article588-595application/pdfhttp://dx.doi.org/10.5935/abc.20150134Arquivos Brasileiros De Cardiologia. Rio De Janeiro: Arquivos Brasileiros Cardiologia, v. 105, n. 6, p. 588-595, 2015.0066-782Xhttp://hdl.handle.net/11449/16505810.5935/abc.20150134S0066-782X2015002500588WOS:000369437800007S0066-782X2015002500588.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros De Cardiologiainfo:eu-repo/semantics/openAccess2024-08-14T17:23:34Zoai:repositorio.unesp.br:11449/165058Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
title |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
spellingShingle |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling Santos de Sa, Felipe Goncalves dos Obesity-Resistance High-Fat Diet Cardiac Function Ca2+ Handling Rats |
title_short |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
title_full |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
title_fullStr |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
title_full_unstemmed |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
title_sort |
Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling |
author |
Santos de Sa, Felipe Goncalves dos |
author_facet |
Santos de Sa, Felipe Goncalves dos Lima-Leopoldo, Ana Paula Jacobsen, Bruno Barcellos Togneri Ferron, Artur Junio Estevam, Wagner Muller Salome Campos, Dijon Henrique [UNESP] Castardeli, Edson Holanda da Cunha, Marcia Regina Cicogna, Antonio Carlos [UNESP] Leopoldo, Andre Soares |
author_role |
author |
author2 |
Lima-Leopoldo, Ana Paula Jacobsen, Bruno Barcellos Togneri Ferron, Artur Junio Estevam, Wagner Muller Salome Campos, Dijon Henrique [UNESP] Castardeli, Edson Holanda da Cunha, Marcia Regina Cicogna, Antonio Carlos [UNESP] Leopoldo, Andre Soares |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Espírito Santo (UFES) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Santos de Sa, Felipe Goncalves dos Lima-Leopoldo, Ana Paula Jacobsen, Bruno Barcellos Togneri Ferron, Artur Junio Estevam, Wagner Muller Salome Campos, Dijon Henrique [UNESP] Castardeli, Edson Holanda da Cunha, Marcia Regina Cicogna, Antonio Carlos [UNESP] Leopoldo, Andre Soares |
dc.subject.por.fl_str_mv |
Obesity-Resistance High-Fat Diet Cardiac Function Ca2+ Handling Rats |
topic |
Obesity-Resistance High-Fat Diet Cardiac Function Ca2+ Handling Rats |
description |
Background: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Methods: Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. Results: The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Conclusion: Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-12-01 2018-11-27T08:30:22Z 2018-11-27T08:30:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5935/abc.20150134 Arquivos Brasileiros De Cardiologia. Rio De Janeiro: Arquivos Brasileiros Cardiologia, v. 105, n. 6, p. 588-595, 2015. 0066-782X http://hdl.handle.net/11449/165058 10.5935/abc.20150134 S0066-782X2015002500588 WOS:000369437800007 S0066-782X2015002500588.pdf |
url |
http://dx.doi.org/10.5935/abc.20150134 http://hdl.handle.net/11449/165058 |
identifier_str_mv |
Arquivos Brasileiros De Cardiologia. Rio De Janeiro: Arquivos Brasileiros Cardiologia, v. 105, n. 6, p. 588-595, 2015. 0066-782X 10.5935/abc.20150134 S0066-782X2015002500588 WOS:000369437800007 S0066-782X2015002500588.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Arquivos Brasileiros De Cardiologia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
588-595 application/pdf |
dc.publisher.none.fl_str_mv |
Arquivos Brasileiros Cardiologia |
publisher.none.fl_str_mv |
Arquivos Brasileiros Cardiologia |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128172335562752 |