Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling

Detalhes bibliográficos
Autor(a) principal: Santos de Sa, Felipe Goncalves dos
Data de Publicação: 2015
Outros Autores: Lima-Leopoldo, Ana Paula, Jacobsen, Bruno Barcellos, Togneri Ferron, Artur Junio, Estevam, Wagner Muller, Salome Campos, Dijon Henrique [UNESP], Castardeli, Edson, Holanda da Cunha, Marcia Regina, Cicogna, Antonio Carlos [UNESP], Leopoldo, Andre Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5935/abc.20150134
http://hdl.handle.net/11449/165058
Resumo: Background: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Methods: Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. Results: The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Conclusion: Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling.
id UNSP_be7bae2f28b63e8bcce4321cdf3c6843
oai_identifier_str oai:repositorio.unesp.br:11449/165058
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ HandlingObesity-ResistanceHigh-Fat DietCardiac FunctionCa2+ HandlingRatsBackground: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Methods: Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. Results: The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Conclusion: Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling.FAPES/ESUniv Fed Espirito Santo, Dept Desportos, Ctr Educ Fis & Desportos, Vitoria, ES, BrazilUniv Estadual Paulista, Fac Med, Dept Clin Med, Sao Paulo, BrazilUniv Estadual Paulista, Fac Med, Dept Clin Med, Sao Paulo, BrazilArquivos Brasileiros CardiologiaUniversidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Santos de Sa, Felipe Goncalves dosLima-Leopoldo, Ana PaulaJacobsen, Bruno BarcellosTogneri Ferron, Artur JunioEstevam, Wagner MullerSalome Campos, Dijon Henrique [UNESP]Castardeli, EdsonHolanda da Cunha, Marcia ReginaCicogna, Antonio Carlos [UNESP]Leopoldo, Andre Soares2018-11-27T08:30:22Z2018-11-27T08:30:22Z2015-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article588-595application/pdfhttp://dx.doi.org/10.5935/abc.20150134Arquivos Brasileiros De Cardiologia. Rio De Janeiro: Arquivos Brasileiros Cardiologia, v. 105, n. 6, p. 588-595, 2015.0066-782Xhttp://hdl.handle.net/11449/16505810.5935/abc.20150134S0066-782X2015002500588WOS:000369437800007S0066-782X2015002500588.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengArquivos Brasileiros De Cardiologiainfo:eu-repo/semantics/openAccess2024-08-14T17:23:34Zoai:repositorio.unesp.br:11449/165058Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:34Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
title Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
spellingShingle Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
Santos de Sa, Felipe Goncalves dos
Obesity-Resistance
High-Fat Diet
Cardiac Function
Ca2+ Handling
Rats
title_short Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
title_full Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
title_fullStr Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
title_full_unstemmed Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
title_sort Obesity Resistance Promotes Mild Contractile Dysfunction Associated with Intracellular Ca2+ Handling
author Santos de Sa, Felipe Goncalves dos
author_facet Santos de Sa, Felipe Goncalves dos
Lima-Leopoldo, Ana Paula
Jacobsen, Bruno Barcellos
Togneri Ferron, Artur Junio
Estevam, Wagner Muller
Salome Campos, Dijon Henrique [UNESP]
Castardeli, Edson
Holanda da Cunha, Marcia Regina
Cicogna, Antonio Carlos [UNESP]
Leopoldo, Andre Soares
author_role author
author2 Lima-Leopoldo, Ana Paula
Jacobsen, Bruno Barcellos
Togneri Ferron, Artur Junio
Estevam, Wagner Muller
Salome Campos, Dijon Henrique [UNESP]
Castardeli, Edson
Holanda da Cunha, Marcia Regina
Cicogna, Antonio Carlos [UNESP]
Leopoldo, Andre Soares
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Espírito Santo (UFES)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Santos de Sa, Felipe Goncalves dos
Lima-Leopoldo, Ana Paula
Jacobsen, Bruno Barcellos
Togneri Ferron, Artur Junio
Estevam, Wagner Muller
Salome Campos, Dijon Henrique [UNESP]
Castardeli, Edson
Holanda da Cunha, Marcia Regina
Cicogna, Antonio Carlos [UNESP]
Leopoldo, Andre Soares
dc.subject.por.fl_str_mv Obesity-Resistance
High-Fat Diet
Cardiac Function
Ca2+ Handling
Rats
topic Obesity-Resistance
High-Fat Diet
Cardiac Function
Ca2+ Handling
Rats
description Background: Diet-induced obesity is frequently used to demonstrate cardiac dysfunction. However, some rats, like humans, are susceptible to developing an obesity phenotype, whereas others are resistant to that. Objective: To evaluate the association between obesity resistance and cardiac function, and the impact of obesity resistance on calcium handling. Methods: Thirty-day-old male Wistar rats were distributed into two groups, each with 54 animals: control (C; standard diet) and obese (four palatable high-fat diets) for 15 weeks. After the experimental protocol, rats consuming the high-fat diets were classified according to the adiposity index and subdivided into obesity-prone (OP) and obesity-resistant (OR). Nutritional profile, comorbidities, and cardiac remodeling were evaluated. Cardiac function was assessed by papillary muscle evaluation at baseline and after inotropic maneuvers. Results: The high-fat diets promoted increase in body fat and adiposity index in OP rats compared with C and OR rats. Glucose, lipid, and blood pressure profiles remained unchanged in OR rats. In addition, the total heart weight and the weight of the left and right ventricles in OR rats were lower than those in OP rats, but similar to those in C rats. Baseline cardiac muscle data were similar in all rats, but myocardial responsiveness to a post-rest contraction stimulus was compromised in OP and OR rats compared with C rats. Conclusion: Obesity resistance promoted specific changes in the contraction phase without changes in the relaxation phase. This mild abnormality may be related to intracellular Ca2+ handling.
publishDate 2015
dc.date.none.fl_str_mv 2015-12-01
2018-11-27T08:30:22Z
2018-11-27T08:30:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5935/abc.20150134
Arquivos Brasileiros De Cardiologia. Rio De Janeiro: Arquivos Brasileiros Cardiologia, v. 105, n. 6, p. 588-595, 2015.
0066-782X
http://hdl.handle.net/11449/165058
10.5935/abc.20150134
S0066-782X2015002500588
WOS:000369437800007
S0066-782X2015002500588.pdf
url http://dx.doi.org/10.5935/abc.20150134
http://hdl.handle.net/11449/165058
identifier_str_mv Arquivos Brasileiros De Cardiologia. Rio De Janeiro: Arquivos Brasileiros Cardiologia, v. 105, n. 6, p. 588-595, 2015.
0066-782X
10.5935/abc.20150134
S0066-782X2015002500588
WOS:000369437800007
S0066-782X2015002500588.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros De Cardiologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 588-595
application/pdf
dc.publisher.none.fl_str_mv Arquivos Brasileiros Cardiologia
publisher.none.fl_str_mv Arquivos Brasileiros Cardiologia
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128172335562752