The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Journal of Medical and Biological Research |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002 |
Resumo: | The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response. |
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Brazilian Journal of Medical and Biological Research |
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The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responsesSLAMSAPIFN-γImmunoreceptorImmunomodulationThe signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.Associação Brasileira de Divulgação Científica2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002Brazilian Journal of Medical and Biological Research v.44 n.4 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500038info:eu-repo/semantics/openAccessVilar,M.L.L.V.Frutuoso,M.S.Arruda,S.M.Lima,D.M.Bezerra,C.S.Pompeu,M.M.L.eng2011-11-11T00:00:00Zoai:scielo:S0100-879X2011000400002Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-11-11T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false |
dc.title.none.fl_str_mv |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
title |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
spellingShingle |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses Vilar,M.L.L.V. SLAM SAP IFN-γ Immunoreceptor Immunomodulation |
title_short |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
title_full |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
title_fullStr |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
title_full_unstemmed |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
title_sort |
The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses |
author |
Vilar,M.L.L.V. |
author_facet |
Vilar,M.L.L.V. Frutuoso,M.S. Arruda,S.M. Lima,D.M. Bezerra,C.S. Pompeu,M.M.L. |
author_role |
author |
author2 |
Frutuoso,M.S. Arruda,S.M. Lima,D.M. Bezerra,C.S. Pompeu,M.M.L. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Vilar,M.L.L.V. Frutuoso,M.S. Arruda,S.M. Lima,D.M. Bezerra,C.S. Pompeu,M.M.L. |
dc.subject.por.fl_str_mv |
SLAM SAP IFN-γ Immunoreceptor Immunomodulation |
topic |
SLAM SAP IFN-γ Immunoreceptor Immunomodulation |
description |
The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-879X2011007500038 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research v.44 n.4 2011 reponame:Brazilian Journal of Medical and Biological Research instname:Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
instname_str |
Associação Brasileira de Divulgação Científica (ABDC) |
instacron_str |
ABDC |
institution |
ABDC |
reponame_str |
Brazilian Journal of Medical and Biological Research |
collection |
Brazilian Journal of Medical and Biological Research |
repository.name.fl_str_mv |
Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC) |
repository.mail.fl_str_mv |
bjournal@terra.com.br||bjournal@terra.com.br |
_version_ |
1754302939425406976 |