The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses

Detalhes bibliográficos
Autor(a) principal: Vilar,M.L.L.V.
Data de Publicação: 2011
Outros Autores: Frutuoso,M.S., Arruda,S.M., Lima,D.M., Bezerra,C.S., Pompeu,M.M.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002
Resumo: The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.
id ABDC-1_11a6bd413ea975b609c3ffbd1d79db4a
oai_identifier_str oai:scielo:S0100-879X2011000400002
network_acronym_str ABDC-1
network_name_str Brazilian Journal of Medical and Biological Research
repository_id_str
spelling The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responsesSLAMSAPIFN-γImmunoreceptorImmunomodulationThe signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.Associação Brasileira de Divulgação Científica2011-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002Brazilian Journal of Medical and Biological Research v.44 n.4 2011reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2011007500038info:eu-repo/semantics/openAccessVilar,M.L.L.V.Frutuoso,M.S.Arruda,S.M.Lima,D.M.Bezerra,C.S.Pompeu,M.M.L.eng2011-11-11T00:00:00Zoai:scielo:S0100-879X2011000400002Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2011-11-11T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
title The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
spellingShingle The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
Vilar,M.L.L.V.
SLAM
SAP
IFN-γ
Immunoreceptor
Immunomodulation
title_short The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
title_full The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
title_fullStr The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
title_full_unstemmed The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
title_sort The role of the SLAM-SAP signaling pathway in the modulation of CD4+ T cell responses
author Vilar,M.L.L.V.
author_facet Vilar,M.L.L.V.
Frutuoso,M.S.
Arruda,S.M.
Lima,D.M.
Bezerra,C.S.
Pompeu,M.M.L.
author_role author
author2 Frutuoso,M.S.
Arruda,S.M.
Lima,D.M.
Bezerra,C.S.
Pompeu,M.M.L.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Vilar,M.L.L.V.
Frutuoso,M.S.
Arruda,S.M.
Lima,D.M.
Bezerra,C.S.
Pompeu,M.M.L.
dc.subject.por.fl_str_mv SLAM
SAP
IFN-γ
Immunoreceptor
Immunomodulation
topic SLAM
SAP
IFN-γ
Immunoreceptor
Immunomodulation
description The signaling lymphocytic activation molecule (SLAM), present on the surface of hematopoietic cells, can regulate some events of the immune responses. This modulatory action is associated with the capacity of SLAM to interact with an intracytoplasmic adapter, such as SLAM-associated protein (SAP). SLAM is constitutively expressed in most of these cells, is rapidly induced after antigenic or inflammatory stimuli, and participates in the immunological synapse. Defects in the function of the SLAM-SAP pathway contribute to immunological abnormalities, resulting in autoimmune diseases, tumors of the lymphoid tissues and inadequate responses to infectious agents. Initially, the role of SLAM was investigated using an anti-SLAM monoclonal antibody (α-SLAM mAb) identified as an agonist of the SLAM-SAP pathway, which could induce the production of interferon-γ and could redirect the immune response to a T helper 1 (Th1) cell profile. However, in this review we postulate that the SLAM-SAP pathway primarily induces a Th2 response and secondarily suppresses the Th1 response.
publishDate 2011
dc.date.none.fl_str_mv 2011-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2011007500038
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.44 n.4 2011
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
_version_ 1754302939425406976