Residual ß-cell function and microvascular complications in type 1 diabetic patients

Detalhes bibliográficos
Autor(a) principal: Gomes,M.B.
Data de Publicação: 2000
Outros Autores: Gonçalves,M.F.R., Neves,R., Cohen,C., Albanesi,F.M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200008
Resumo: To determine the influence of residual ß-cell function on retinopathy and microalbuminuria we measured basal C-peptide in 50 type 1 diabetic outpatients aged 24.96 ± 7.14 years, with a duration of diabetes of 9.1 ± 6.2 years. Forty-three patients (86%) with low C-peptide (&lt;0.74 ng/ml) had longer duration of diabetes than 7 patients (14%) with high C-peptide (<FONT FACE="Symbol">³</font>0.74 ng/ml) (9 (2-34) vs 3 (1-10) years, P = 0.01) and a tendency to high glycated hemoglobin (HBA1) (8.8 (6-17.9) vs 7.7 (6.9-8.7)%, P = 0.08). Nine patients (18%) had microalbuminuria (two out of three overnight urine samples with an albumin excretion rate (AER) <FONT FACE="Symbol">³</font>20 and &lt;200 µg/min) and 13 (26%) had background retinopathy. No association was found between low C-peptide, microalbuminuria and retinopathy and no difference in basal C-peptide was observed between microalbuminuric and normoalbuminuric patients (0.4 ± 0.5 vs 0.19 ± 0.22 ng/ml, P = 0.61) and between patients with or without retinopathy (0.4 ± 0.6 vs 0.2 ± 0.3 ng/ml, P = 0.43). Multiple regression analysis showed that duration of diabetes (r = 0.30, r2 = 0.09, P = 0.031) followed by HBA1 (r = 0.41, r2 = 0.17, P = 0.01) influenced basal C-peptide, and this duration of diabetes was the only variable affecting AER (r = 0.40, r2 = 0.16, P = 0.004). In our sample of type 1 diabetic patients residual ß-cell function was not associated with microalbuminuria or retinopathy.
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spelling Residual ß-cell function and microvascular complications in type 1 diabetic patientsC-peptidemicroalbuminuriaretinopathydiabetes type 1To determine the influence of residual ß-cell function on retinopathy and microalbuminuria we measured basal C-peptide in 50 type 1 diabetic outpatients aged 24.96 ± 7.14 years, with a duration of diabetes of 9.1 ± 6.2 years. Forty-three patients (86%) with low C-peptide (&lt;0.74 ng/ml) had longer duration of diabetes than 7 patients (14%) with high C-peptide (<FONT FACE="Symbol">³</font>0.74 ng/ml) (9 (2-34) vs 3 (1-10) years, P = 0.01) and a tendency to high glycated hemoglobin (HBA1) (8.8 (6-17.9) vs 7.7 (6.9-8.7)%, P = 0.08). Nine patients (18%) had microalbuminuria (two out of three overnight urine samples with an albumin excretion rate (AER) <FONT FACE="Symbol">³</font>20 and &lt;200 µg/min) and 13 (26%) had background retinopathy. No association was found between low C-peptide, microalbuminuria and retinopathy and no difference in basal C-peptide was observed between microalbuminuric and normoalbuminuric patients (0.4 ± 0.5 vs 0.19 ± 0.22 ng/ml, P = 0.61) and between patients with or without retinopathy (0.4 ± 0.6 vs 0.2 ± 0.3 ng/ml, P = 0.43). Multiple regression analysis showed that duration of diabetes (r = 0.30, r2 = 0.09, P = 0.031) followed by HBA1 (r = 0.41, r2 = 0.17, P = 0.01) influenced basal C-peptide, and this duration of diabetes was the only variable affecting AER (r = 0.40, r2 = 0.16, P = 0.004). In our sample of type 1 diabetic patients residual ß-cell function was not associated with microalbuminuria or retinopathy.Associação Brasileira de Divulgação Científica2000-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200008Brazilian Journal of Medical and Biological Research v.33 n.2 2000reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2000000200008info:eu-repo/semantics/openAccessGomes,M.B.Gonçalves,M.F.R.Neves,R.Cohen,C.Albanesi,F.M.eng2000-02-02T00:00:00Zoai:scielo:S0100-879X2000000200008Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2000-02-02T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Residual ß-cell function and microvascular complications in type 1 diabetic patients
title Residual ß-cell function and microvascular complications in type 1 diabetic patients
spellingShingle Residual ß-cell function and microvascular complications in type 1 diabetic patients
Gomes,M.B.
C-peptide
microalbuminuria
retinopathy
diabetes type 1
title_short Residual ß-cell function and microvascular complications in type 1 diabetic patients
title_full Residual ß-cell function and microvascular complications in type 1 diabetic patients
title_fullStr Residual ß-cell function and microvascular complications in type 1 diabetic patients
title_full_unstemmed Residual ß-cell function and microvascular complications in type 1 diabetic patients
title_sort Residual ß-cell function and microvascular complications in type 1 diabetic patients
author Gomes,M.B.
author_facet Gomes,M.B.
Gonçalves,M.F.R.
Neves,R.
Cohen,C.
Albanesi,F.M.
author_role author
author2 Gonçalves,M.F.R.
Neves,R.
Cohen,C.
Albanesi,F.M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Gomes,M.B.
Gonçalves,M.F.R.
Neves,R.
Cohen,C.
Albanesi,F.M.
dc.subject.por.fl_str_mv C-peptide
microalbuminuria
retinopathy
diabetes type 1
topic C-peptide
microalbuminuria
retinopathy
diabetes type 1
description To determine the influence of residual ß-cell function on retinopathy and microalbuminuria we measured basal C-peptide in 50 type 1 diabetic outpatients aged 24.96 ± 7.14 years, with a duration of diabetes of 9.1 ± 6.2 years. Forty-three patients (86%) with low C-peptide (&lt;0.74 ng/ml) had longer duration of diabetes than 7 patients (14%) with high C-peptide (<FONT FACE="Symbol">³</font>0.74 ng/ml) (9 (2-34) vs 3 (1-10) years, P = 0.01) and a tendency to high glycated hemoglobin (HBA1) (8.8 (6-17.9) vs 7.7 (6.9-8.7)%, P = 0.08). Nine patients (18%) had microalbuminuria (two out of three overnight urine samples with an albumin excretion rate (AER) <FONT FACE="Symbol">³</font>20 and &lt;200 µg/min) and 13 (26%) had background retinopathy. No association was found between low C-peptide, microalbuminuria and retinopathy and no difference in basal C-peptide was observed between microalbuminuric and normoalbuminuric patients (0.4 ± 0.5 vs 0.19 ± 0.22 ng/ml, P = 0.61) and between patients with or without retinopathy (0.4 ± 0.6 vs 0.2 ± 0.3 ng/ml, P = 0.43). Multiple regression analysis showed that duration of diabetes (r = 0.30, r2 = 0.09, P = 0.031) followed by HBA1 (r = 0.41, r2 = 0.17, P = 0.01) influenced basal C-peptide, and this duration of diabetes was the only variable affecting AER (r = 0.40, r2 = 0.16, P = 0.004). In our sample of type 1 diabetic patients residual ß-cell function was not associated with microalbuminuria or retinopathy.
publishDate 2000
dc.date.none.fl_str_mv 2000-02-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2000000200008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.33 n.2 2000
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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