HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors

Detalhes bibliográficos
Autor(a) principal: Pereira,J.S.F.
Data de Publicação: 2006
Outros Autores: Gonçales,N.S.L., Silva,C., Lazarini,M.S.K., Pavan,M.H.P., Fais,V.C., Gonçales Júnior,F.L.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400013
Resumo: Anti-HBc positivity is a frequent cause of donation rejection at blood banks. Hepatitis B virus (HBV) infection may also occur in HBsAg-negative patients, a situation denoted occult infection. Similarly, very low levels of HBV-DNA have also been found in the sera of patients with chronic hepatitis C virus (HCV) infection, even in the absence of serum HBsAg. Initially we searched for HBV-DNA in serum of 100 blood donors and 50 HCV-infected patients who were HBsAg negative/anti-HBc positive by nested-PCR and by an HBV monitor commercial test for HBV-DNA. Anti-HBs seroconversion rates were measured in 100 blood donors and in 22 patients with chronic HCV infection after HBV vaccination to determine if the HBV vaccination could eliminate an occult HBV infection in these individuals. Occult HBV infection was detected in proportionally fewer blood donors (6/100 = 6%) than chronic hepatitis C patients (12/50 = 24%) (P < 0.05). We noted seroconversion in 6/6 (100%) HBV-DNA(+) and in 84/94 (89.4%) HBV-DNA(-) blood donors (P > 0.05). All subjects who were HBV-DNA(+) before the first dose of HBV vaccine (D1), became HBV-DNA(-) after D1, D2, and D3. Among 22 HCV-positive patients, 10 HBV-DNA(+) and 12 HBV-DNA(-), seroconversion was observed in 9/10 (90%) HBV-DNA(+) and in 9/12 (75%) HBV-DNA(-) subjects (P > 0.05). The disappearance of HBV-DNA in the majority of vaccinated patients suggests that residual HBV can be eliminated in patients with occult infection.
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spelling HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donorsPolymerase chain reactionAnti-HBc-positive patientsHCV co-infectionHBV vaccinationOccult HBV infectionAnti-HBc positivity is a frequent cause of donation rejection at blood banks. Hepatitis B virus (HBV) infection may also occur in HBsAg-negative patients, a situation denoted occult infection. Similarly, very low levels of HBV-DNA have also been found in the sera of patients with chronic hepatitis C virus (HCV) infection, even in the absence of serum HBsAg. Initially we searched for HBV-DNA in serum of 100 blood donors and 50 HCV-infected patients who were HBsAg negative/anti-HBc positive by nested-PCR and by an HBV monitor commercial test for HBV-DNA. Anti-HBs seroconversion rates were measured in 100 blood donors and in 22 patients with chronic HCV infection after HBV vaccination to determine if the HBV vaccination could eliminate an occult HBV infection in these individuals. Occult HBV infection was detected in proportionally fewer blood donors (6/100 = 6%) than chronic hepatitis C patients (12/50 = 24%) (P < 0.05). We noted seroconversion in 6/6 (100%) HBV-DNA(+) and in 84/94 (89.4%) HBV-DNA(-) blood donors (P > 0.05). All subjects who were HBV-DNA(+) before the first dose of HBV vaccine (D1), became HBV-DNA(-) after D1, D2, and D3. Among 22 HCV-positive patients, 10 HBV-DNA(+) and 12 HBV-DNA(-), seroconversion was observed in 9/10 (90%) HBV-DNA(+) and in 9/12 (75%) HBV-DNA(-) subjects (P > 0.05). The disappearance of HBV-DNA in the majority of vaccinated patients suggests that residual HBV can be eliminated in patients with occult infection.Associação Brasileira de Divulgação Científica2006-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400013Brazilian Journal of Medical and Biological Research v.39 n.4 2006reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2006000400013info:eu-repo/semantics/openAccessPereira,J.S.F.Gonçales,N.S.L.Silva,C.Lazarini,M.S.K.Pavan,M.H.P.Fais,V.C.Gonçales Júnior,F.L.eng2006-04-03T00:00:00Zoai:scielo:S0100-879X2006000400013Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2006-04-03T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
title HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
spellingShingle HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
Pereira,J.S.F.
Polymerase chain reaction
Anti-HBc-positive patients
HCV co-infection
HBV vaccination
Occult HBV infection
title_short HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
title_full HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
title_fullStr HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
title_full_unstemmed HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
title_sort HBV vaccination of HCV-infected patients with occult HBV infection and anti-HBc-positive blood donors
author Pereira,J.S.F.
author_facet Pereira,J.S.F.
Gonçales,N.S.L.
Silva,C.
Lazarini,M.S.K.
Pavan,M.H.P.
Fais,V.C.
Gonçales Júnior,F.L.
author_role author
author2 Gonçales,N.S.L.
Silva,C.
Lazarini,M.S.K.
Pavan,M.H.P.
Fais,V.C.
Gonçales Júnior,F.L.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Pereira,J.S.F.
Gonçales,N.S.L.
Silva,C.
Lazarini,M.S.K.
Pavan,M.H.P.
Fais,V.C.
Gonçales Júnior,F.L.
dc.subject.por.fl_str_mv Polymerase chain reaction
Anti-HBc-positive patients
HCV co-infection
HBV vaccination
Occult HBV infection
topic Polymerase chain reaction
Anti-HBc-positive patients
HCV co-infection
HBV vaccination
Occult HBV infection
description Anti-HBc positivity is a frequent cause of donation rejection at blood banks. Hepatitis B virus (HBV) infection may also occur in HBsAg-negative patients, a situation denoted occult infection. Similarly, very low levels of HBV-DNA have also been found in the sera of patients with chronic hepatitis C virus (HCV) infection, even in the absence of serum HBsAg. Initially we searched for HBV-DNA in serum of 100 blood donors and 50 HCV-infected patients who were HBsAg negative/anti-HBc positive by nested-PCR and by an HBV monitor commercial test for HBV-DNA. Anti-HBs seroconversion rates were measured in 100 blood donors and in 22 patients with chronic HCV infection after HBV vaccination to determine if the HBV vaccination could eliminate an occult HBV infection in these individuals. Occult HBV infection was detected in proportionally fewer blood donors (6/100 = 6%) than chronic hepatitis C patients (12/50 = 24%) (P < 0.05). We noted seroconversion in 6/6 (100%) HBV-DNA(+) and in 84/94 (89.4%) HBV-DNA(-) blood donors (P > 0.05). All subjects who were HBV-DNA(+) before the first dose of HBV vaccine (D1), became HBV-DNA(-) after D1, D2, and D3. Among 22 HCV-positive patients, 10 HBV-DNA(+) and 12 HBV-DNA(-), seroconversion was observed in 9/10 (90%) HBV-DNA(+) and in 9/12 (75%) HBV-DNA(-) subjects (P > 0.05). The disappearance of HBV-DNA in the majority of vaccinated patients suggests that residual HBV can be eliminated in patients with occult infection.
publishDate 2006
dc.date.none.fl_str_mv 2006-04-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400013
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2006000400013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.39 n.4 2006
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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