Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation

Detalhes bibliográficos
Autor(a) principal: Heldin,P.
Data de Publicação: 2003
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Brazilian Journal of Medical and Biological Research
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800002
Resumo: Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired.
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spelling Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formationHyaluronanSynthaseHyaluronidaseTumor invasionExtracellular matrixPericellular matrixHyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired.Associação Brasileira de Divulgação Científica2003-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800002Brazilian Journal of Medical and Biological Research v.36 n.8 2003reponame:Brazilian Journal of Medical and Biological Researchinstname:Associação Brasileira de Divulgação Científica (ABDC)instacron:ABDC10.1590/S0100-879X2003000800002info:eu-repo/semantics/openAccessHeldin,P.eng2003-07-23T00:00:00Zoai:scielo:S0100-879X2003000800002Revistahttps://www.bjournal.org/https://old.scielo.br/oai/scielo-oai.phpbjournal@terra.com.br||bjournal@terra.com.br1414-431X0100-879Xopendoar:2003-07-23T00:00Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)false
dc.title.none.fl_str_mv Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
title Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
spellingShingle Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
Heldin,P.
Hyaluronan
Synthase
Hyaluronidase
Tumor invasion
Extracellular matrix
Pericellular matrix
title_short Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
title_full Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
title_fullStr Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
title_full_unstemmed Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
title_sort Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
author Heldin,P.
author_facet Heldin,P.
author_role author
dc.contributor.author.fl_str_mv Heldin,P.
dc.subject.por.fl_str_mv Hyaluronan
Synthase
Hyaluronidase
Tumor invasion
Extracellular matrix
Pericellular matrix
topic Hyaluronan
Synthase
Hyaluronidase
Tumor invasion
Extracellular matrix
Pericellular matrix
description Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired.
publishDate 2003
dc.date.none.fl_str_mv 2003-08-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-879X2003000800002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv Brazilian Journal of Medical and Biological Research v.36 n.8 2003
reponame:Brazilian Journal of Medical and Biological Research
instname:Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
instname_str Associação Brasileira de Divulgação Científica (ABDC)
instacron_str ABDC
institution ABDC
reponame_str Brazilian Journal of Medical and Biological Research
collection Brazilian Journal of Medical and Biological Research
repository.name.fl_str_mv Brazilian Journal of Medical and Biological Research - Associação Brasileira de Divulgação Científica (ABDC)
repository.mail.fl_str_mv bjournal@terra.com.br||bjournal@terra.com.br
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