Extracellular matrix mimics using hyaluronan-based biomaterials

Detalhes bibliográficos
Autor(a) principal: Amorim, S.
Data de Publicação: 2021
Outros Autores: Reis, C. A., Reis, R. L., Pires, R. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/65963
Resumo: Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.
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spelling Extracellular matrix mimics using hyaluronan-based biomaterials3D hydrogelsECM modelsHyaluronanparticlesSurfaces2D surfaces3D modelsextracellular matrixhydrogelsScience & TechnologyHyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.The authors acknowledge thefinancial support from the European Commission’s H2020 programme, under grantagreements H2020-WIDESPREAD-2014-668983-FORECAST, and H2020-MSCA-RISE-2019-872648-MEPHOS. S.A.acknowledges the Portuguese Foundation for Science and Technology (FCT) for her PhD grant (SFRH/BD/112075/2015).Cell PressUniversidade do MinhoAmorim, S.Reis, C. A.Reis, R. L.Pires, R. A.20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/65963engAmorim S., Reis C. A., Reis R. L., Pires R. A. Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials, Trends in Biotechnology, doi:10.1016/j.tibtech.2020.06.003, 2021.0167-779910.1016/j.tibtech.2020.06.00332654775https://doi.org/10.1016/j.tibtech.2020.06.003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:29Zoai:repositorium.sdum.uminho.pt:1822/65963Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:14:48.575482Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Extracellular matrix mimics using hyaluronan-based biomaterials
title Extracellular matrix mimics using hyaluronan-based biomaterials
spellingShingle Extracellular matrix mimics using hyaluronan-based biomaterials
Amorim, S.
3D hydrogels
ECM models
Hyaluronan
particles
Surfaces
2D surfaces
3D models
extracellular matrix
hydrogels
Science & Technology
title_short Extracellular matrix mimics using hyaluronan-based biomaterials
title_full Extracellular matrix mimics using hyaluronan-based biomaterials
title_fullStr Extracellular matrix mimics using hyaluronan-based biomaterials
title_full_unstemmed Extracellular matrix mimics using hyaluronan-based biomaterials
title_sort Extracellular matrix mimics using hyaluronan-based biomaterials
author Amorim, S.
author_facet Amorim, S.
Reis, C. A.
Reis, R. L.
Pires, R. A.
author_role author
author2 Reis, C. A.
Reis, R. L.
Pires, R. A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Amorim, S.
Reis, C. A.
Reis, R. L.
Pires, R. A.
dc.subject.por.fl_str_mv 3D hydrogels
ECM models
Hyaluronan
particles
Surfaces
2D surfaces
3D models
extracellular matrix
hydrogels
Science & Technology
topic 3D hydrogels
ECM models
Hyaluronan
particles
Surfaces
2D surfaces
3D models
extracellular matrix
hydrogels
Science & Technology
description Hyaluronan (HA) is a critical element of the extracellular matrix (ECM). The regulated synthesis and degradation of HA modulates the ECM chemical and physical properties that, in turn, influence cellular behavior. HA triggers signaling pathways associated with the adhesion, proliferation, migration, and differentiation of cells, mediated by its interaction with specific cellular receptors or by tuning the mechanical properties of the ECM. This review summarizes the recent advances on strategies used to mimic the HA present in the ECM to study healthy or pathological cellular behavior. This includes the development of HA-based 2D and 3D in vitro tissue models for the seeding and encapsulation of cells, respectively, and HA particles as carriers for the targeted delivery of therapeutic agents.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/65963
url http://hdl.handle.net/1822/65963
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Amorim S., Reis C. A., Reis R. L., Pires R. A. Extracellular Matrix Mimics Using Hyaluronan-Based Biomaterials, Trends in Biotechnology, doi:10.1016/j.tibtech.2020.06.003, 2021.
0167-7799
10.1016/j.tibtech.2020.06.003
32654775
https://doi.org/10.1016/j.tibtech.2020.06.003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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